Protein: E2AK4
eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein)

Gene: E2AK4, EIF2AK4
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q9P2K8

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000077 - DNA damage checkpoint signaling
GO:0002230 - positive regulation of defense response to virus by host
GO:0002250 - adaptive immune response
GO:0002286 - T cell activation involved in immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1169031

DEFI8
Differentially expressed in FDCP 8 homolog

2

7

High-throughput

0.726

High

738097

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

4

7

High-throughput

0.699

High

906178

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

4

7

High-throughput

0.699

High

243650

DNJA2
DnaJ homolog subfamily A member 2

1

5

High-throughput

0.691

High

276284

CIB2
Calcium and integrin-binding family member 2

1

20

High-throughput

0.691

High

569022

CAN2
Calpain-2 catalytic subunit

1

7

High-throughput

0.691

High

1316221

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.691

High

1350435

OCTC
Peroxisomal carnitine O-octanoyltransferase

3

0

High-throughput

0.638

High

169311

MDM4
Protein Mdm4

2

3

High-throughput

0.628

High

573096

PRS6A
26S proteasome regulatory subunit 6A

2

6

High-throughput

0.628

High

666984

TKT
Transketolase

2

1

High-throughput

0.628

High

375017

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

17

High-throughput

0.618

High

780246

CCNF
Cyclin-F

1

4

High-throughput

0.618

High

1020597

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

5

Small-scale

0.618

High

1066813

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.618

High

1083028

CDC37
Hsp90 co-chaperone Cdc37

1

11

High-throughput

0.618

High

1162532

Q6PK50
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

1172079

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.618

High

1331509

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.618

High

1350438

CRYL1
Lambda-crystallin homolog

2

0

High-throughput

0.602

High

967485

EWS
RNA-binding protein EWS

1

1

High-throughput

0.590

High

1132269

CF141
Uncharacterized protein C6orf141

2

1

High-throughput

0.574

High

1166880

LRC31
Leucine-rich repeat-containing protein 31

1

5

High-throughput

0.553

High

365102

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

515965

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.536

High

639108

S100P
Protein S100-P

1

7

High-throughput

0.536

High

686088

ARRB2
Beta-arrestin-2

1

3

High-throughput

0.536

High

790053

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

3

High-throughput

0.536

High

795582

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

2

High-throughput

0.536

High

796196

MAGA9
Melanoma-associated antigen 9

1

6

High-throughput

0.536

High

1023009

CDC16
Cell division cycle protein 16 homolog

1

8

High-throughput

0.536

High

1136448

KAD9
Adenylate kinase 9

1

3

High-throughput

0.536

High

1284833

EFMT3
EEF1A lysine methyltransferase 3

1

9

High-throughput

0.536

High

1318413

UBXN6
UBX domain-containing protein 6

1

3

High-throughput

0.536

High

1350326

KLH14
Kelch-like protein 14

1

5

High-throughput

0.536

High

403990

ITB1
Integrin beta-1

1

3

High-throughput

0.515

High

602882

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

794161

MATR3
Matrin-3

1

0

High-throughput

0.513

High

985264

HME1
Homeobox protein engrailed-1

1

0

High-throughput

0.513

High

996131

HDHD1
Pseudouridine-5'-phosphatase

1

0

High-throughput

0.513

High

905406

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

0

High-throughput

0.493

High

1160862

PGM2L
Glucose 1,6-bisphosphate synthase

1

0

High-throughput

0.493

High

1231204

KLH34
Kelch-like protein 34

1

5

High-throughput

0.489

High

73186

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

1

High-throughput

0.479

High

124951

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

1

High-throughput

0.479

High

324090

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.479

High

570139

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

685072

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.479

High

786173

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

885620

MLF1
Myeloid leukemia factor 1

1

2

High-throughput

0.479

High

959737

VIGLN
Vigilin

1

7

High-throughput

0.479

High

1027811

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.479

High

1035614

SMAD4
Mothers against decapentaplegic homolog 4

1

5

High-throughput

0.479

High

1078366

MLF2
Myeloid leukemia factor 2

1

2

High-throughput

0.479

High

1120592

Q53FC7
Heat shock 70kDa protein 6

1

9

High-throughput

0.479

High

1188975

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1217451

NUDC3
NudC domain-containing protein 3

1

3

High-throughput

0.479

High

1242675

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

7

Small-scale

0.479

High

1246190

COP1
E3 ubiquitin-protein ligase COP1

1

5

High-throughput

0.479

High

1268275

GCN1
Stalled ribosome sensor GCN1

1

6

Small-scale

0.479

High

1281443

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1285459

Q96BE0
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.479

High

1312176

AASD1
Alanyl-tRNA editing protein Aarsd1

1

1

High-throughput

0.479

High

1316100

EIF2A
Eukaryotic translation initiation factor 2A

1

5

Small-scale

0.479

High

1335122

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.479

High

1350434

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1243977

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

56763

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

3

High-throughput

0.445

High

1349907

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

4

High-throughput

0.407

High

1350437

PLAK2
PALM2-AKAP2 fusion protein

2

0

High-throughput

0.288

High

1350436

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.279

Low

473259

F153B
Protein FAM153B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024