Protein: SPT16
FACT complex subunit spt16 (Facilitates chromatin transcription complex subunit SPT16) (dSPT16)

Gene: SPT16, dre4
Organism: Drosophila melanogaster
Interactions: 103
UniProt ID: Q8IRG6

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005703 - polytene chromosome puff
GO:0005730 - nucleolus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1050898

SSRP1
FACT complex subunit Ssrp1

5

15

Small-scale

0.902

High

1064537

GAGA
Transcription activator GAGA

2

3

Small-scale

0.624

High

1306331

CID
Histone H3-like centromeric protein cid

1

10

Small-scale

0.618

High

426703

HP1
Heterochromatin protein 1

2

2

Small-scale

0.571

High

1306320

Q8T0D3
Protein DEK

1

2

High-throughput

0.479

High

1306336

Q9VCU6
Heterochromatin protein 1c

1

3

Small-scale

0.479

High

1306376

Q9W396
FI06908p

1

3

Small-scale

0.479

High

1306360

PYRG
CTP synthase

1

0

High-throughput

0.458

High

54170

A1Z898
Chromatin assembly factor 1, p105 subunit

1

6

High-throughput

0.445

High

54520

TPR
Nucleoprotein TPR

1

1

High-throughput

0.445

High

56839

A1ZAK3
Protein DEK

1

2

High-throughput

0.445

High

231841

DKC1
H/ACA ribonucleoprotein complex subunit 4

1

1

High-throughput

0.445

High

467176

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.445

High

669772

RCC1
Regulator of chromosome condensation

1

1

High-throughput

0.445

High

773378

RFC1
Replication factor C subunit 1

1

4

High-throughput

0.445

High

847873

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.445

High

925803

SET
Protein SET

1

1

High-throughput

0.445

High

1173911

ISWI
Chromatin-remodeling complex ATPase chain Iswi

1

7

High-throughput

0.445

High

1174407

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.445

High

1177456

Q29QQ9
Ribosomal RNA-processing protein 42

1

2

High-throughput

0.445

High

1261883

Q7JRJ9
Inner centromere protein, isoform A

1

1

High-throughput

0.445

High

1285439

MMD4
Modifier of mdg4

1

3

High-throughput

0.445

High

1304036

SLE
Protein slender lobes

1

1

High-throughput

0.445

High

1306318

GLYR1
Cytokine-like nuclear factor N-PAC

1

2

High-throughput

0.445

High

1306324

EBI
F-box-like/WD repeat-containing protein ebi

1

7

High-throughput

0.445

High

1306327

RUVB2
RuvB-like helicase 2

1

2

High-throughput

0.445

High

1306328

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

1

High-throughput

0.445

High

1306332

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

4

High-throughput

0.445

High

1306333

Q9VAA9
JIL-1 anchoring and stabilizing protein, isoform A

1

4

High-throughput

0.445

High

1306337

Q9VDL2
LD40493p

1

7

High-throughput

0.445

High

1306338

EXOSX
Exosome complex component 10 homolog

1

1

High-throughput

0.445

High

1306339

Q9VGZ2
FI06805p

1

2

High-throughput

0.445

High

1306340

RUVB1
RuvB-like helicase 1

1

2

High-throughput

0.445

High

1306346

Q9VIH1
CG9273 protein

1

4

High-throughput

0.445

High

1306347

RAGP1
Ran GTPase-activating protein

1

1

High-throughput

0.445

High

1306348

Q9VJ12
Acinus, isoform A

1

1

High-throughput

0.445

High

1306349

Q9VK19
FI07225p

1

3

High-throughput

0.445

High

1306361

NDC
Nuclear migration protein nudC

1

1

High-throughput

0.445

High

1306364

Q9VW53
FI01414p

1

3

High-throughput

0.445

High

1306366

RUXG
Probable small nuclear ribonucleoprotein G

1

1

High-throughput

0.445

High

1306381

DDB1
DNA damage-binding protein 1

1

1

High-throughput

0.445

High

235133

O46307
EG:8D8.4 protein

1

0

High-throughput

0.426

High

263607

FLOT2
Flotillin-2

1

0

High-throughput

0.426

High

699339

RRP1
Recombination repair protein 1

1

0

High-throughput

0.426

High

1236951

Q6NP69
GST-containing FLYWCH zinc-finger protein

1

0

High-throughput

0.426

High

1264886

Q7K1Q7
Ribosome assembly factor mrt4

1

0

High-throughput

0.426

High

1269598

MED13
Mediator of RNA polymerase II transcription subunit 13

1

0

High-throughput

0.426

High

1270117

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.426

High

1304996

EXOS3
Exosome complex component RRP40

1

0

High-throughput

0.426

High

1306316

INDRA
Zinc finger protein indra

1

0

High-throughput

0.426

High

1306322

Q94513
Boundary element associated factor

1

0

Small-scale

0.426

High

1306325

MYSN
Myosin heavy chain, non-muscle

1

0

High-throughput

0.426

High

1306326

NASP
Nuclear autoantigenic sperm protein homolog

1

0

High-throughput

0.426

High

1306329

Q9V3V9
Endonuclease G inhibitor, isoform A

1

0

High-throughput

0.426

High

1306335

Q9VC93
Exosome complex exonuclease RRP44

1

0

High-throughput

0.426

High

1306341

Q9VHG5
Insulator binding factor 1, isoform A

1

0

High-throughput

0.426

High

1306345

SMD2
Probable small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.426

High

1306352

Q9VNX6
LD06749p

1

0

High-throughput

0.426

High

1306356

DBR1
Lariat debranching enzyme

1

0

High-throughput

0.426

High

1306365

Q9VX35
LD36501p

1

0

High-throughput

0.426

High

1306367

SYRC
Probable arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

1306374

Q9W1M6
Regulatory protein zeste

1

0

High-throughput

0.426

High

1306377

Q9W3D1
Chromatin assembly factor 1, p180 subunit

1

0

High-throughput

0.426

High

1306378

Q9W3J4
LD35215p

1

0

High-throughput

0.426

High

1306379

Q9W4J4
GM14292p

1

0

High-throughput

0.426

High

1306380

Q9W542
LD07342p

1

0

High-throughput

0.426

High

1306383

SYQ
Probable glutamine--tRNA ligase

1

0

High-throughput

0.426

High

84807

B7Z0I8
Titin

1

1

High-throughput

0.407

High

882990

SDC
Syndecan

1

1

High-throughput

0.407

High

1303649

Q8IN95
Nuclear migration protein nudC

1

1

High-throughput

0.407

High

1306319

WDR55
WD repeat-containing protein 55 homolog

1

6

High-throughput

0.407

High

1306321

Q8T4A9
Exosome complex component RRP45

1

3

High-throughput

0.407

High

1306330

RU2A
Probable U2 small nuclear ribonucleoprotein A'

1

4

High-throughput

0.407

High

1306343

Q9VHR5
Veneno

1

1

High-throughput

0.407

High

1306351

Q9VM14
dihydrolipoyllysine-residue acetyltransferase

1

2

High-throughput

0.407

High

1306359

RM39
Large ribosomal subunit protein mL39

1

1

High-throughput

0.407

High

1306362

Q9VVF8
Uncharacterized protein, isoform A

1

1

High-throughput

0.407

High

1306363

Q9VVI0
SD09427p

1

7

High-throughput

0.407

High

1306368

Q9VXY3
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

1

2

High-throughput

0.407

High

1306369

Q9VYT3
FI23714p1

1

3

High-throughput

0.407

High

1306372

Q9W108
FI01540p

1

1

High-throughput

0.407

High

1306384

Q9Y134
RNA helicase

1

3

High-throughput

0.407

High

1306342

Q9VHP9
Centromeric protein-C, isoform A

1

0

Small-scale

0.249

Low

723798

DLG1
Disks large 1 tumor suppressor protein

1

0

High-throughput

0.232

Low

1261160

Q7JNE1
Regulatory protein zeste

1

0

High-throughput

0.232

Low

1261390

Q7JQT8
LD41464p

1

0

High-throughput

0.232

Low

1264266

Q7K0L8
FLICE-associated huge protein, isoform A

1

0

High-throughput

0.232

Low

1305520

Q8IQI3
Uncharacterized protein, isoform B

1

0

High-throughput

0.232

Low

1306317

Q8MMD2
Epidermal growth factor receptor pathway substrate clone 15, isoform B

1

0

High-throughput

0.232

Low

1306323

DYLT
Dynein light chain Tctex-type

1

0

High-throughput

0.232

Low

1306334

Q9VBT1
CHK kinase-like domain-containing protein

1

0

High-throughput

0.232

Low

1306344

Q9VHT5
Large ribosomal subunit protein uL1m

1

0

High-throughput

0.232

Low

1306350

Q9VKW8
U6 snRNA-associated Sm-like protein LSm4

1

0

High-throughput

0.232

Low

1306353

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.232

Low

1306354

Q9VPM0
GH06023p

1

0

High-throughput

0.232

Low

1306355

Q9VQS4
Spindly

1

0

High-throughput

0.232

Low

1306357

QTRT2
Queuine tRNA-ribosyltransferase accessory subunit 2

1

0

High-throughput

0.232

Low

1306358

Q9VT38
GH03795p

1

0

High-throughput

0.232

Low

1306370

Q9VYY7
Heterochromatin protein 5, isoform B

1

0

High-throughput

0.232

Low

1306371

THUM1
THUMP domain-containing protein 1 homolog

1

0

High-throughput

0.232

Low

1306373

Q9W140
Regulatory protein zeste

1

0

High-throughput

0.232

Low

1306375

Q9W1M9
Exosome complex component RRP4

1

0

High-throughput

0.232

Low

1306382

Q9Y0Y5
Coatomer subunit epsilon

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025