Protein: TOM70
Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70)

Gene: TOM70, TOMM70
Organism: Homo sapiens
Interactions: 119
UniProt ID: O94826

Gene Ontology (top 5):
GO:0002218 - activation of innate immune response
GO:0002230 - positive regulation of defense response to virus by host
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005742 - mitochondrial outer membrane translocase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

297024

HS90A
Heat shock protein HSP 90-alpha

3

20

Small-scale

0.873

High

226108

PRKN
E3 ubiquitin-protein ligase parkin

7

13

Small-scale

0.743

High

174501

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

16

High-throughput

0.647

High

297025

HS90B
Heat shock protein HSP 90-beta

1

20

Small-scale

0.618

High

297056

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

19

High-throughput

0.618

High

297017

TOM40
Mitochondrial import receptor subunit TOM40 homolog

2

4

Small-scale

0.611

High

297079

H2B1H
Histone H2B type 1-H

2

8

High-throughput

0.601

High

297080

TTC28
Tetratricopeptide repeat protein 28

1

17

High-throughput

0.595

High

297085

DDX27
Probable ATP-dependent RNA helicase DDX27

1

9

High-throughput

0.595

High

297095

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

15

Small-scale

0.595

High

297014

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

11

High-throughput

0.584

High

297015

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

3

High-throughput

0.584

High

297029

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

2

High-throughput

0.584

High

297061

TOM20
Mitochondrial import receptor subunit TOM20 homolog

2

3

Small-scale

0.584

High

297108

MARH5
E3 ubiquitin-protein ligase MARCHF5

2

1

Small-scale

0.584

High

297019

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

297066

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

11

High-throughput

0.571

High

297058

IRF3
Interferon regulatory factor 3

1

2

Small-scale

0.561

High

297103

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

203842

HTRA2
Serine protease HTRA2, mitochondrial

1

2

High-throughput

0.554

High

297088

IMP1L
Mitochondrial inner membrane protease subunit 1

1

4

High-throughput

0.554

High

297021

HSPB1
Heat shock protein beta-1

1

12

High-throughput

0.541

High

297041

GDIB
Rab GDP dissociation inhibitor beta

1

5

High-throughput

0.536

High

297044

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

4

High-throughput

0.536

High

297071

MAVS
Mitochondrial antiviral-signaling protein

1

11

Small-scale

0.515

High

254852

CPNE3
Copine-3

1

0

High-throughput

0.513

High

297096

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

297089

IMP2L
Mitochondrial inner membrane protease subunit 2

1

4

High-throughput

0.506

High

58026

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.493

High

297038

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.493

High

297032

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

5

High-throughput

0.489

High

297035

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

2

High-throughput

0.489

High

297050

TBA1B
Tubulin alpha-1B chain

1

17

High-throughput

0.489

High

297054

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.489

High

297060

TEBP
Prostaglandin E synthase 3

1

9

High-throughput

0.489

High

297076

RIN3
Ras and Rab interactor 3

1

7

High-throughput

0.489

High

231034

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

4

High-throughput

0.479

High

274460

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

7

High-throughput

0.479

High

297018

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.479

High

297023

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

297027

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.479

High

297028

ADT3
ADP/ATP translocase 3

1

8

Small-scale

0.479

High

297034

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

2

Small-scale

0.479

High

297047

H2B1D
Histone H2B type 1-D

1

8

High-throughput

0.479

High

297049

H2B1C
Histone H2B type 1-C/E/F/G/I

1

8

High-throughput

0.479

High

297051

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

1

High-throughput

0.479

High

297057

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

297059

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.479

High

297064

H2B2E
Histone H2B type 2-E

1

8

High-throughput

0.479

High

297070

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

4

Small-scale

0.479

High

297072

STING
Stimulator of interferon genes protein

1

3

Small-scale

0.479

High

297075

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

297077

AKAP1
A-kinase anchor protein 1, mitochondrial

1

7

High-throughput

0.479

High

297078

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

297084

RN185
E3 ubiquitin-protein ligase RNF185

1

7

Small-scale

0.479

High

297090

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

2

High-throughput

0.479

High

297092

PHB2
Prohibitin-2

1

4

High-throughput

0.479

High

297093

H2B1L
Histone H2B type 1-L

1

8

High-throughput

0.479

High

297097

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

14

Small-scale

0.479

High

297098

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

9

High-throughput

0.479

High

297106

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.479

High

297107

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.479

High

297109

MTCH1
Mitochondrial carrier homolog 1

1

13

High-throughput

0.479

High

297111

TBK1
Serine/threonine-protein kinase TBK1

1

16

Small-scale

0.479

High

297115

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

297116

TRRAP
Transformation/transcription domain-associated protein

1

8

High-throughput

0.479

High

297117

TRAF6
TNF receptor-associated factor 6

1

9

Small-scale

0.479

High

297118

MTCH2
Mitochondrial carrier homolog 2

1

17

High-throughput

0.479

High

297043

IRAK1
Interleukin-1 receptor-associated kinase 1

1

4

High-throughput

0.470

High

297073

AHNK2
Protein AHNAK2

1

2

High-throughput

0.470

High

297074

AMPO
Aminopeptidase O

1

1

High-throughput

0.470

High

157497

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.458

High

276766

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

297062

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

Small-scale

0.458

High

297065

MIDN
Midnolin

1

0

High-throughput

0.458

High

297083

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

297086

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

297094

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

297099

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

297105

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

297026

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

297039

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.445

High

297045

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

12

High-throughput

0.445

High

297114

WDR37
WD repeat-containing protein 37

1

13

High-throughput

0.445

High

159307

PLD2
Phospholipase D2

1

6

High-throughput

0.437

High

241402

H2B1K
Histone H2B type 1-K

1

8

High-throughput

0.437

High

297012

EPM2A
Laforin

1

3

High-throughput

0.437

High

297016

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

297020

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.437

High

297022

H2B1J
Histone H2B type 1-J

1

8

High-throughput

0.437

High

297030

RFA2
Replication protein A 32 kDa subunit

1

11

High-throughput

0.437

High

297031

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.437

High

297036

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

High-throughput

0.437

High

297037

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

297040

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.437

High

297042

CDK7
Cyclin-dependent kinase 7

1

6

High-throughput

0.437

High

297046

KLF3
Krueppel-like factor 3

1

9

High-throughput

0.437

High

297048

WDR5
WD repeat-containing protein 5

1

11

High-throughput

0.437

High

297053

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.437

High

297063

E2F4
Transcription factor E2F4

1

1

High-throughput

0.437

High

297068

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

297069

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.437

High

297082

OPTN
Optineurin

1

6

High-throughput

0.437

High

297091

EYA3
Eyes absent homolog 3

1

2

High-throughput

0.437

High

297100

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

2

Small-scale

0.437

High

297101

Q9H4D1
Protein kinase

1

12

High-throughput

0.437

High

297102

EGLN3
Prolyl hydroxylase EGLN3

1

5

High-throughput

0.437

High

297110

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.437

High

297112

FBXL4
F-box/LRR-repeat protein 4

1

3

Small-scale

0.437

High

297113

TRI33
E3 ubiquitin-protein ligase TRIM33

1

8

High-throughput

0.437

High

275356

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

297087

SPTCS
Spatacsin

1

1

Small-scale

0.417

High

297013

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.282

High

297033

BTF3
Transcription factor BTF3

1

0

High-throughput

0.279

Low

297067

MSL1
Male-specific lethal 1 homolog

1

0

High-throughput

0.269

Low

297052

RL36A
Large ribosomal subunit protein eL42

1

0

High-throughput

0.249

Low

297055

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

High-throughput

0.249

Low

297081

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.249

Low

297104

PLRKT
Plasminogen receptor

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024