Protein: RING2
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)

Gene: RING2, Rnf2
Organism: Mus musculus
Interactions: 134
UniProt ID: Q9CQJ4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000151 - ubiquitin ligase complex
GO:0000278 - mitotic cell cycle
GO:0000791 - euchromatin
GO:0000792 - heterochromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

683130

BMI1
Polycomb complex protein BMI-1

8

19

Small-scale

0.975

High

1298254

RYBP
RING1 and YY1-binding protein

7

20

Small-scale

0.958

High

662911

PCGF2
Polycomb group RING finger protein 2

6

19

Small-scale

0.953

High

205499

RING1
E3 ubiquitin-protein ligase RING1

4

20

Small-scale

0.892

High

1423698

RING2
E3 ubiquitin-protein ligase RING2

4

20

Small-scale

0.890

High

1354000

CBX7
Chromobox protein homolog 7

3

20

Small-scale

0.867

High

1298578

BCOR
BCL-6 corepressor

2

20

Small-scale

0.802

High

1423710

CBX8
Chromobox protein homolog 8

2

20

Small-scale

0.802

High

1341428

PCGF1
Polycomb group RING finger protein 1

2

19

Small-scale

0.789

High

1408929

PCGF6
Polycomb group RING finger protein 6

2

20

Small-scale

0.789

High

1423709

PHC2
Polyhomeotic-like protein 2

7

20

Small-scale

0.745

High

1225159

PHC1
Polyhomeotic-like protein 1

7

20

Small-scale

0.742

High

237306

CBX4
E3 SUMO-protein ligase CBX4

1

20

Small-scale

0.691

High

721344

CBX2
Chromobox protein homolog 2

1

20

Small-scale

0.691

High

1190383

PCGF5
Polycomb group RING finger protein 5

1

19

Small-scale

0.691

High

1297354

PCGF3
Polycomb group RING finger protein 3

1

19

Small-scale

0.691

High

1408843

YAF2
YY1-associated factor 2

1

20

Small-scale

0.691

High

1240615

KDM2B
Lysine-specific demethylase 2B

3

20

Small-scale

0.674

High

1253523

KDM1A
Lysine-specific histone demethylase 1A

3

6

Small-scale

0.662

High

947457

LMBL2
Lethal(3)malignant brain tumor-like protein 2

3

20

Small-scale

0.656

High

1230577

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

20

Small-scale

0.656

High

1423703

CBX6
Chromobox protein homolog 6

1

20

Small-scale

0.618

High

59872

MGAP
MAX gene-associated protein

2

12

Small-scale

0.611

High

629435

PO5F1
POU domain, class 5, transcription factor 1

2

13

High-throughput

0.611

High

965403

WDR5
WD repeat-containing protein 5

2

16

Small-scale

0.611

High

1317255

SCMH1
Polycomb protein SCMH1

3

20

Small-scale

0.603

High

1000037

HDAC2
Histone deacetylase 2

2

15

Small-scale

0.584

High

1221415

CSK21
Casein kinase II subunit alpha

2

20

Small-scale

0.584

High

1283183

NANOG
Homeobox protein NANOG

2

20

High-throughput

0.584

High

1297522

RBBP5
Retinoblastoma-binding protein 5

2

15

Small-scale

0.584

High

1247833

Q6TKP2
Neuronal pentraxin with chromo domain

1

20

Small-scale

0.575

High

59549

AF9
Protein AF-9

1

12

Small-scale

0.561

High

1423712

SKP1
S-phase kinase-associated protein 1

1

13

Small-scale

0.554

High

704117

MAX
Protein max

2

19

Small-scale

0.552

High

1243995

Q6PED7
Auts2 protein

2

20

Small-scale

0.549

High

236481

CSK22
Casein kinase II subunit alpha'

1

20

Small-scale

0.536

High

694283

XRCC5
X-ray repair cross-complementing protein 5

1

7

Small-scale

0.536

High

989280

HSP7C
Heat shock cognate 71 kDa protein

1

10

Small-scale

0.536

High

995388

CSK2B
Casein kinase II subunit beta

1

10

Small-scale

0.536

High

1064617

TFDP1
Transcription factor Dp-1

1

5

Small-scale

0.536

High

1190696

TF2L1
Transcription factor CP2-like protein 1

1

7

High-throughput

0.536

High

1204125

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

6

Small-scale

0.536

High

1216965

THOC6
THO complex subunit 6 homolog

1

20

Small-scale

0.536

High

1222081

RBBP4
Histone-binding protein RBBP4

1

13

Small-scale

0.536

High

1222104

RBBP7
Histone-binding protein RBBP7

1

16

Small-scale

0.536

High

1222410

Q61177
Casein kinase II subunit alpha

1

20

Small-scale

0.536

High

1296652

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

17

Small-scale

0.536

High

1297024

KAISO
Transcriptional regulator Kaiso

1

20

Small-scale

0.536

High

1298650

PHC3
Polyhomeotic-like protein 3

1

20

Small-scale

0.536

High

1317142

CDC73
Parafibromin

1

1

Small-scale

0.536

High

1317325

MATR3
Matrin-3

1

15

Small-scale

0.536

High

1317406

MTA1
Metastasis-associated protein MTA1

1

8

Small-scale

0.536

High

1362468

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

Small-scale

0.536

High

1243175

SPA24
Spermatogenesis-associated protein 24

1

1

Small-scale

0.501

High

398

AUTS2
Autism susceptibility gene 2 protein homolog

1

20

Small-scale

0.500

High

59241

MED14
Mediator of RNA polymerase II transcription subunit 14

1

15

Small-scale

0.479

High

98344

E9QLK7
Transformation/transcription domain-associated protein

1

11

Small-scale

0.479

High

104414

F6M2J9
Nuclear receptor coactivator-6 beta

1

11

Small-scale

0.479

High

109309

G5E8N3
Histone-lysine N-methyltransferase SETDB1

1

7

Small-scale

0.479

High

236674

E2F6
Transcription factor E2F6

1

17

Small-scale

0.479

High

266590

AURKB
Aurora kinase B

1

12

Small-scale

0.479

High

267208

KDM6A
Lysine-specific demethylase 6A

1

17

Small-scale

0.479

High

646756

ZFP42
Zinc finger protein 42

1

20

Small-scale

0.479

High

871750

RFX1
MHC class II regulatory factor RFX1

1

7

Small-scale

0.479

High

873043

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.479

High

879775

MAPK2
MAP kinase-activated protein kinase 2

1

5

Small-scale

0.479

High

941637

CTBP2
C-terminal-binding protein 2

1

10

Small-scale

0.479

High

953287

ACTB
Actin, cytoplasmic 1

1

20

Small-scale

0.479

High

953369

MO4L1
Mortality factor 4-like protein 1

1

2

Small-scale

0.479

High

964796

DCAF7
DDB1- and CUL4-associated factor 7

1

20

Small-scale

0.479

High

994025

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

6

Small-scale

0.479

High

1061498

PEBB
Core-binding factor subunit beta

1

2

Small-scale

0.479

High

1063105

GATA4
Transcription factor GATA-4

1

18

Small-scale

0.479

High

1189346

HP1B3
Heterochromatin protein 1-binding protein 3

1

3

Small-scale

0.479

High

1191001

RNPC3
RNA-binding region-containing protein 3

1

8

Small-scale

0.479

High

1222573

PLSL
Plastin-2

1

15

Small-scale

0.479

High

1222898

ERR2
Steroid hormone receptor ERR2

1

17

Small-scale

0.479

High

1240229

PAXI1
PAX-interacting protein 1

1

12

Small-scale

0.479

High

1242750

MBTD1
MBT domain-containing protein 1

1

20

Small-scale

0.479

High

1253347

PF21A
PHD finger protein 21A

1

20

Small-scale

0.479

High

1274507

MBB1A
Myb-binding protein 1A

1

3

Small-scale

0.479

High

1274640

SGO2A
Shugoshin 2A

1

1

Small-scale

0.479

High

1282856

NPM2
Nucleoplasmin-2

1

5

Small-scale

0.479

High

1283001

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

Small-scale

0.479

High

1295885

ACTBL
Beta-actin-like protein 2

1

20

Small-scale

0.479

High

1296956

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

20

Small-scale

0.479

High

1297235

Q8BQ46
TAF15 RNA polymerase II, TATA box binding protein

1

20

Small-scale

0.479

High

1297363

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

9

Small-scale

0.479

High

1297538

SALL4
Sal-like protein 4

1

7

Small-scale

0.479

High

1297579

Q8BYC8
Scm polycomb group protein-like 2

1

20

Small-scale

0.479

High

1297680

EPC2
Enhancer of polycomb homolog 2

1

3

Small-scale

0.479

High

1298196

EPC1
Enhancer of polycomb homolog 1

1

3

Small-scale

0.479

High

1298594

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

15

Small-scale

0.479

High

1298624

EP400
E1A-binding protein p400

1

20

Small-scale

0.479

High

1341554

BRD8
Bromodomain-containing protein 8

1

20

Small-scale

0.479

High

1353874

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

Small-scale

0.479

High

1362324

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

19

Small-scale

0.479

High

1362630

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

1423699

CENPV
Centromere protein V

1

1

Small-scale

0.479

High

1423700

ZN687
Zinc finger protein 687

1

9

Small-scale

0.479

High

1423701

PHF14
PHD finger protein 14

1

8

Small-scale

0.479

High

1423704

HM20A
High mobility group protein 20A

1

18

Small-scale

0.479

High

1423705

Q9DCC5
Cbx3 protein

1

20

Small-scale

0.479

High

1423706

Q9ERL0
Btk-PH-domain binding protein

1

12

Small-scale

0.479

High

1423707

PALLD
Palladin

1

12

Small-scale

0.479

High

1423708

DMAP1
DNA methyltransferase 1-associated protein 1

1

3

Small-scale

0.479

High

1423711

RUVB2
RuvB-like 2

1

5

Small-scale

0.479

High

1423713

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

4

Small-scale

0.479

High

1423714

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

20

Small-scale

0.479

High

1423715

ACL6A
Actin-like protein 6A

1

20

Small-scale

0.479

High

1408769

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

Small-scale

0.458

High

1408809

PGR1A
PAXIP1-associated glutamate-rich protein 1A

1

0

Small-scale

0.458

High

1423655

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.458

High

1423702

MRGBP
MRG/MORF4L-binding protein

1

0

Small-scale

0.458

High

313221

SETB1
Histone-lysine N-methyltransferase SETDB1

1

7

Small-scale

0.445

High

654695

CBX3
Chromobox protein homolog 3

1

20

Small-scale

0.445

High

1274654

MCAF1
Activating transcription factor 7-interacting protein 1

1

15

Small-scale

0.445

High

1297385

TOX4
TOX high mobility group box family member 4

1

20

Small-scale

0.445

High

1298777

Q8CJ76
Leukemia-associated protein MLLT1

1

13

Small-scale

0.445

High

1354094

Q8VHT4
E2F6b

1

17

Small-scale

0.445

High

1362432

Q91YZ2
C-terminal-binding protein 2

1

10

Small-scale

0.445

High

1363044

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

4

Small-scale

0.445

High

98213

E9Q7C1
Mediator of RNA polymerase II transcription subunit 15

1

17

Small-scale

0.437

High

993115

ACTG
Actin, cytoplasmic 2

1

20

Small-scale

0.437

High

1190559

Q3UM65
Runt-related transcription factor

1

7

Small-scale

0.437

High

1196869

WDR18
WD repeat-containing protein 18

1

17

Small-scale

0.437

High

1223366

PZP
Pregnancy zone protein

1

3

Small-scale

0.437

High

1224215

CCNC
Cyclin-C

1

6

Small-scale

0.437

High

1298150

Q8C839
Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat domain-containing protein

1

3

Small-scale

0.437

High

1354058

RBM39
RNA-binding protein 39

1

20

Small-scale

0.437

High

1362268

POTE1
Protection of telomeres protein 1

1

1

Small-scale

0.437

High

1283483

Q80ZU1
DDB1- and CUL4-associated factor 7

1

20

Small-scale

0.407

High

97861

E9Q284
Coilin

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025