Protein: NRG1
Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]

Gene: NRG1
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q02297

Gene Ontology (top 5):
GO:0003222 - ventricular trabecula myocardium morphogenesis
GO:0003712 - transcription coregulator activity
GO:0005102 - signaling receptor binding
GO:0005125 - cytokine activity
GO:0005178 - integrin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

601899

ERBB3
Receptor tyrosine-protein kinase erbB-3

10

19

Small-scale

0.978

High

338301

EGFR
Epidermal growth factor receptor

4

18

Small-scale

0.884

High

300346

AGRL1
Adhesion G protein-coupled receptor L1

3

1

High-throughput

0.861

High

970270

TMTC4
Protein O-mannosyl-transferase TMTC4

3

2

High-throughput

0.861

High

970280

ZDH17
Palmitoyltransferase ZDHHC17

3

7

High-throughput

0.861

High

970267

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

18

Small-scale

0.792

High

970309

CNTP3
Contactin-associated protein-like 3

2

6

High-throughput

0.789

High

426826

ASGR2
Asialoglycoprotein receptor 2

2

7

High-throughput

0.783

High

601786

CD72
B-cell differentiation antigen CD72

2

8

High-throughput

0.783

High

970284

LARG2
Xylosyl- and glucuronyltransferase LARGE2

3

0

High-throughput

0.720

High

851458

NEK4
Serine/threonine-protein kinase Nek4

2

2

High-throughput

0.705

High

383750

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

17

Small-scale

0.692

High

970308

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

4

High-throughput

0.691

High

727447

ATP7B
Copper-transporting ATPase 2

3

1

High-throughput

0.667

High

970265

SRBP2
Sterol regulatory element-binding protein 2

3

3

High-throughput

0.667

High

970327

POMT1
Protein O-mannosyl-transferase 1

3

1

High-throughput

0.667

High

225298

H6ST1
Heparan-sulfate 6-O-sulfotransferase 1

3

0

High-throughput

0.638

High

970269

CSCL2
CSC1-like protein 2

3

0

High-throughput

0.638

High

970277

LSR
Lipolysis-stimulated lipoprotein receptor

3

0

High-throughput

0.638

High

970285

CISD2
CDGSH iron-sulfur domain-containing protein 2

3

0

High-throughput

0.638

High

970292

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

3

0

High-throughput

0.638

High

970310

TM39B
Transmembrane protein 39B

3

0

High-throughput

0.638

High

970317

INT7
Integrator complex subunit 7

3

0

High-throughput

0.638

High

970273

TMTC3
Protein O-mannosyl-transferase TMTC3

1

2

High-throughput

0.618

High

382593

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

2

5

High-throughput

0.611

High

970325

MAN1
Inner nuclear membrane protein Man1

2

1

High-throughput

0.611

High

301197

RHBT3
Rho-related BTB domain-containing protein 3

3

16

High-throughput

0.609

High

557330

GDC
Solute carrier family 25 member 16

3

2

High-throughput

0.609

High

970290

GLT11
Polypeptide N-acetylgalactosaminyltransferase 11

3

2

High-throughput

0.609

High

970306

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

3

2

High-throughput

0.609

High

970307

SFXN3
Sideroflexin-3

3

1

High-throughput

0.609

High

970318

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

3

2

High-throughput

0.609

High

970271

TM164
Transmembrane protein 164

2

0

High-throughput

0.585

High

970282

K2013
Uncharacterized protein KIAA2013

2

0

High-throughput

0.585

High

970294

GLMN
Glomulin

2

0

High-throughput

0.585

High

970297

S22AI
Solute carrier family 22 member 18

2

0

High-throughput

0.585

High

970301

MBOA7
Lysophospholipid acyltransferase 7

2

0

High-throughput

0.585

High

970305

TM2D3
TM2 domain-containing protein 3

2

0

High-throughput

0.585

High

888245

MYPR
Myelin proteolipid protein

2

0

High-throughput

0.580

High

970276

LAP4B
Lysosomal-associated transmembrane protein 4B

2

0

High-throughput

0.580

High

970296

TMM54
Transmembrane protein 54

2

0

High-throughput

0.580

High

970300

M4A4A
Membrane-spanning 4-domains subfamily A member 4A

2

0

High-throughput

0.580

High

863764

LIMK1
LIM domain kinase 1

1

6

Small-scale

0.573

High

970289

B3GL2
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

2

2

High-throughput

0.558

High

199452

SPIT1
Kunitz-type protease inhibitor 1

1

3

High-throughput

0.536

High

295720

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

2

High-throughput

0.536

High

488196

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.536

High

518125

ADT1
ADP/ATP translocase 1

1

1

High-throughput

0.536

High

850463

PLXA3
Plexin-A3

1

3

High-throughput

0.536

High

970303

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

970324

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

2

High-throughput

0.536

High

970326

ORNT1
Mitochondrial ornithine transporter 1

1

3

High-throughput

0.536

High

970295

H2B1H
Histone H2B type 1-H

1

12

High-throughput

0.515

High

58804

T131L
Transmembrane protein 131-like

1

0

High-throughput

0.513

High

157561

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.513

High

206904

CHSTA
Carbohydrate sulfotransferase 10

1

0

High-throughput

0.513

High

739589

SCNNA
Amiloride-sensitive sodium channel subunit alpha

1

0

High-throughput

0.513

High

901915

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.513

High

970283

S35F6
Solute carrier family 35 member F6

1

0

High-throughput

0.513

High

970311

SEM6B
Semaphorin-6B

1

0

High-throughput

0.513

High

970322

B4GT7
Beta-1,4-galactosyltransferase 7

1

0

High-throughput

0.513

High

642937

S10A4
Protein S100-A4

1

3

Small-scale

0.501

High

970266

TBB3
Tubulin beta-3 chain

1

5

High-throughput

0.489

High

970275

GALT5
Polypeptide N-acetylgalactosaminyltransferase 5

1

2

High-throughput

0.489

High

970281

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

2

High-throughput

0.489

High

970302

SFXN2
Sideroflexin-2

1

1

High-throughput

0.489

High

348625

RASN
GTPase NRas

1

12

High-throughput

0.479

High

970278

GOLI
E3 ubiquitin-protein ligase RNF130

1

7

High-throughput

0.479

High

970299

MYO19
Unconventional myosin-XIX

1

6

High-throughput

0.479

High

970304

ABCA3
Phospholipid-transporting ATPase ABCA3

1

2

High-throughput

0.479

High

970320

MTCH1
Mitochondrial carrier homolog 1

1

3

High-throughput

0.479

High

58435

F234B
Protein FAM234B

1

0

High-throughput

0.458

High

168250

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.458

High

217159

EXTL3
Exostosin-like 3

1

0

High-throughput

0.458

High

452220

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.458

High

643224

MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

1

0

High-throughput

0.458

High

970272

TM205
Transmembrane protein 205

1

0

High-throughput

0.458

High

970288

NETO2
Neuropilin and tolloid-like protein 2

1

0

High-throughput

0.458

High

970312

PIGU
Phosphatidylinositol glycan anchor biosynthesis class U protein

1

0

High-throughput

0.458

High

970314

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.458

High

970319

CALY
Neuron-specific vesicular protein calcyon

1

0

Small-scale

0.458

High

970321

TM181
Transmembrane protein 181

1

0

High-throughput

0.458

High

354943

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

5

High-throughput

0.445

High

100689

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

970291

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

970293

RDH11
Retinol dehydrogenase 11

1

1

High-throughput

0.437

High

970298

C1GLC
C1GALT1-specific chaperone 1

1

2

High-throughput

0.437

High

970274

PGAP1
GPI inositol-deacylase

3

0

High-throughput

0.347

High

970279

DAAF5
Dynein axonemal assembly factor 5

3

0

High-throughput

0.347

High

970323

DSE
Dermatan-sulfate epimerase

3

0

High-throughput

0.347

High

970287

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

2

0

High-throughput

0.318

High

970313

OPA3
Optic atrophy 3 protein

2

0

High-throughput

0.318

High

970286

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.316

High

970268

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

0

High-throughput

0.279

Low

970315

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.279

Low

159478

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.249

Low

174202

SPTC2
Serine palmitoyltransferase 2

1

0

High-throughput

0.249

Low

306400

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.249

Low

970316

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024