Protein: DDB2
DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2)

Gene: DDB2
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q92466

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003684 - damaged DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1082302

DDB1
DNA damage-binding protein 1

40

19

Small-scale

0.995

High

1043128

CUL4A
Cullin-4A

31

20

Small-scale

0.769

High

1043483

CUL4B
Cullin-4B

11

20

Small-scale

0.759

High

1265882

CSN5
COP9 signalosome complex subunit 5

11

10

Small-scale

0.757

High

921363

RBX1
E3 ubiquitin-protein ligase RBX1

9

6

Small-scale

0.753

High

1184924

CSN6
COP9 signalosome complex subunit 6

9

6

Small-scale

0.752

High

1265891

CSN4
COP9 signalosome complex subunit 4

7

2

Small-scale

0.746

High

1265910

CSN7A
COP9 signalosome complex subunit 7a

7

4

Small-scale

0.746

High

1265916

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

7

Small-scale

0.740

High

897282

CSN2
COP9 signalosome complex subunit 2

6

9

Small-scale

0.730

High

1265889

CSN8
COP9 signalosome complex subunit 8

6

2

Small-scale

0.730

High

967059

XPC
DNA repair protein complementing XP-C cells

5

3

Small-scale

0.714

High

1265915

CSN3
COP9 signalosome complex subunit 3

5

8

Small-scale

0.714

High

309870

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

1

High-throughput

0.691

High

1265896

PDCL3
Phosducin-like protein 3

1

8

High-throughput

0.691

High

1024195

CSN1
COP9 signalosome complex subunit 1

4

10

Small-scale

0.686

High

1265894

DDA1
DET1- and DDB1-associated protein 1

3

2

High-throughput

0.675

High

1265888

PFD5
Prefoldin subunit 5

3

9

High-throughput

0.667

High

1265898

CSN7B
COP9 signalosome complex subunit 7b

3

4

High-throughput

0.667

High

1265901

PFD4
Prefoldin subunit 4

3

6

High-throughput

0.667

High

1240557

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

3

0

High-throughput

0.638

High

1173990

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

11

Small-scale

0.637

High

127120

FOXN3
Forkhead box protein N3

2

10

High-throughput

0.628

High

1149923

TIGD3
Tigger transposable element-derived protein 3

2

4

High-throughput

0.628

High

1265906

GTSE1
G2 and S phase-expressed protein 1

2

1

High-throughput

0.628

High

1265911

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

2

1

High-throughput

0.628

High

1265913

PFD2
Prefoldin subunit 2

2

6

High-throughput

0.628

High

1191271

WDR53
WD repeat-containing protein 53

1

17

High-throughput

0.618

High

896166

UBC12
NEDD8-conjugating enzyme Ubc12

1

12

High-throughput

0.618

High

903394

WDR5
WD repeat-containing protein 5

1

18

High-throughput

0.618

High

1028013

ERCC8
DNA excision repair protein ERCC-8

1

17

Small-scale

0.618

High

1063521

SUZ12
Polycomb protein SUZ12

1

2

Small-scale

0.618

High

1080173

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

Small-scale

0.618

High

1246128

COP1
E3 ubiquitin-protein ligase COP1

1

20

High-throughput

0.618

High

1265879

DDB2
DNA damage-binding protein 2

1

14

Small-scale

0.618

High

1265897

WDR76
WD repeat-containing protein 76

1

18

High-throughput

0.618

High

1265904

DCA13
DDB1- and CUL4-associated factor 13

1

18

Small-scale

0.618

High

1265907

DTL
Denticleless protein homolog

1

16

Small-scale

0.618

High

943382

TCPB
T-complex protein 1 subunit beta

3

20

High-throughput

0.616

High

1265890

TCPH
T-complex protein 1 subunit eta

3

20

High-throughput

0.616

High

1182937

SPT6H
Transcription elongation factor SPT6

2

7

High-throughput

0.611

High

826798

TCPG
T-complex protein 1 subunit gamma

3

20

High-throughput

0.609

High

996500

FGL1
Fibrinogen-like protein 1

3

2

High-throughput

0.609

High

487619

ANDR
Androgen receptor

2

20

Small-scale

0.595

High

228216

PRKN
E3 ubiquitin-protein ligase parkin

2

17

High-throughput

0.584

High

917668

H4
Histone H4

2

11

High-throughput

0.584

High

998926

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.584

High

1038580

HDAC1
Histone deacetylase 1

2

20

Small-scale

0.584

High

963652

E2F1
Transcription factor E2F1

1

3

Small-scale

0.578

High

1236403

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

Small-scale

0.578

High

225013

ZNRD2
Protein ZNRD2

2

2

High-throughput

0.574

High

821337

TCPE
T-complex protein 1 subunit epsilon

2

20

High-throughput

0.574

High

863901

CRBA4
Beta-crystallin A4

2

1

High-throughput

0.574

High

130332

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

19

Small-scale

0.561

High

612489

XPA
DNA repair protein complementing XP-A cells

1

1

Small-scale

0.561

High

1265887

DCR1C
Protein artemis

1

5

Small-scale

0.561

High

770960

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.558

High

1265903

PDRG1
p53 and DNA damage-regulated protein 1

2

1

High-throughput

0.558

High

714562

GRK5
G protein-coupled receptor kinase 5

1

7

High-throughput

0.553

High

1265900

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.553

High

499972

CH60
60 kDa heat shock protein, mitochondrial

1

17

High-throughput

0.536

High

842978

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.536

High

843310

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.536

High

1069451

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1087300

H2B2E
Histone H2B type 2-E

1

19

High-throughput

0.536

High

1199077

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

3

High-throughput

0.536

High

1230666

CCNQ
Cyclin-Q

1

4

High-throughput

0.536

High

1263336

CSN9
COP9 signalosome complex subunit 9

1

1

High-throughput

0.536

High

1265883

CUL5
Cullin-5

1

20

High-throughput

0.536

High

1265909

RBX2
RING-box protein 2

1

7

High-throughput

0.536

High

1265917

SMAG1
Protein Smaug homolog 1

1

1

High-throughput

0.536

High

296617

TPPP
Tubulin polymerization-promoting protein

1

1

High-throughput

0.515

High

772085

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.515

High

988111

RAD51
DNA repair protein RAD51 homolog 1

1

2

Small-scale

0.501

High

1087068

H2A2C
Histone H2A type 2-C

1

15

Small-scale

0.501

High

1174611

H32
Histone H3.2

1

20

Small-scale

0.501

High

243525

DNJA2
DnaJ homolog subfamily A member 2

1

16

High-throughput

0.489

High

573397

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.489

High

1119132

KHDC1
KH homology domain-containing protein 1

1

1

High-throughput

0.489

High

1121786

ANR39
Ankyrin repeat domain-containing protein 39

1

7

High-throughput

0.489

High

1265880

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.489

High

1265893

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

1

0

Small-scale

0.480

High

131478

IMA4
Importin subunit alpha-4

1

6

High-throughput

0.479

High

136057

ACACB
Acetyl-CoA carboxylase 2

1

20

High-throughput

0.479

High

244713

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

266492

SUPT3
Transcription initiation protein SPT3 homolog

1

2

Small-scale

0.479

High

309722

KAT7
Histone acetyltransferase KAT7

1

6

Small-scale

0.479

High

391818

H2A1B
Histone H2A type 1-B/E

1

15

High-throughput

0.479

High

398050

ISG15
Ubiquitin-like protein ISG15

1

9

High-throughput

0.479

High

455708

PARP1
Poly [ADP-ribose] polymerase 1

1

12

Small-scale

0.479

High

509071

TOP2A
DNA topoisomerase 2-alpha

1

10

High-throughput

0.479

High

517386

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.479

High

523904

XRCC6
X-ray repair cross-complementing protein 6

1

7

Small-scale

0.479

High

525001

XRCC5
X-ray repair cross-complementing protein 5

1

7

Small-scale

0.479

High

537976

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.479

High

551791

DESP
Desmoplakin

1

20

High-throughput

0.479

High

553305

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

707696

H2B1B
Histone H2B type 1-B

1

19

High-throughput

0.479

High

758297

CDN1A
Cyclin-dependent kinase inhibitor 1

1

1

Small-scale

0.479

High

839021

EMD
Emerin

1

3

Small-scale

0.479

High

875160

TERA
Transitional endoplasmic reticulum ATPase

1

6

Small-scale

0.479

High

882957

RBM11
Splicing regulator RBM11

1

12

High-throughput

0.479

High

935050

H31
Histone H3.1

1

20

Small-scale

0.479

High

941234

RNF4
E3 ubiquitin-protein ligase RNF4

1

7

High-throughput

0.479

High

973372

TOP2B
DNA topoisomerase 2-beta

1

10

High-throughput

0.479

High

1027955

TBX2
T-box transcription factor TBX2

1

5

Small-scale

0.479

High

1265881

JARD2
Protein Jumonji

1

10

Small-scale

0.479

High

1265884

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

1

High-throughput

0.479

High

1265886

ZN512
Zinc finger protein 512

1

1

High-throughput

0.479

High

1265899

CLSPN
Claspin

1

7

Small-scale

0.479

High

1265902

TOPRS
E3 ubiquitin-protein ligase Topors

1

2

Small-scale

0.479

High

1265912

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1265914

HERC5
E3 ISG15--protein ligase HERC5

1

7

Small-scale

0.479

High

1265918

CD11A
Cyclin-dependent kinase 11A

1

10

High-throughput

0.479

High

1265919

SP16H
FACT complex subunit SPT16

1

7

High-throughput

0.479

High

268503

BAF
Barrier-to-autointegration factor

1

0

Small-scale

0.458

High

1265892

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.458

High

1265895

CDT1
DNA replication factor Cdt1

1

0

Small-scale

0.458

High

1265908

UVRAG
UV radiation resistance-associated gene protein

1

0

Small-scale

0.458

High

87386

C9JFE4
G protein pathway suppressor 1

1

7

High-throughput

0.445

High

91399

E7EM64
COP9 signalosome complex subunit 6

1

6

High-throughput

0.445

High

92482

E9PGT6
COP9 signalosome subunit 8

1

2

High-throughput

0.445

High

879142

SUMO3
Small ubiquitin-related modifier 3

1

1

Small-scale

0.445

High

1028405

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

9

Small-scale

0.437

High

508634

TOP1
DNA topoisomerase 1

1

6

Small-scale

0.408

High

1024720

TRAF3
TNF receptor-associated factor 3

1

9

High-throughput

0.407

High

1265905

SPAT6
Spermatogenesis-associated protein 6

2

0

High-throughput

0.328

High

1164592

PAQR3
Progestin and adipoQ receptor family member 3

2

0

Small-scale

0.325

High

1235930

MET27
Methyltransferase-like protein 27

1

0

High-throughput

0.279

Low

1265885

P3IP1
Phosphoinositide-3-kinase-interacting protein 1

1

0

High-throughput

0.279

Low

58379

HYKK
Hydroxylysine kinase

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024