Protein: PIGR
Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component]

Gene: PIGR
Organism: Homo sapiens
Interactions: 135
UniProt ID: P01833

Gene Ontology (top 5):
GO:0001580 - detection of chemical stimulus involved in sensory perception of bitter taste
GO:0001790 - polymeric immunoglobulin binding
GO:0001792 - polymeric immunoglobulin receptor activity
GO:0002415 - immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

353455

HVCN1
Voltage-gated hydrogen channel 1

2

1

High-throughput

0.789

High

353467

DDX31
ATP-dependent DNA helicase DDX31

2

1

High-throughput

0.726

High

297565

RHBT1
Rho-related BTB domain-containing protein 1

1

1

High-throughput

0.691

High

353418

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.691

High

353426

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

1

High-throughput

0.691

High

353442

FNDC5
Fibronectin type III domain-containing protein 5

1

2

High-throughput

0.691

High

116951

SGK1
Serine/threonine-protein kinase Sgk1

1

1

High-throughput

0.665

High

353371

LEG1
Galectin-1

1

1

High-throughput

0.665

High

353395

UCP2
Dicarboxylate carrier SLC25A8

2

0

High-throughput

0.660

High

134506

FCN1
Ficolin-1

1

0

High-throughput

0.656

High

353386

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.656

High

353390

CLCN2
Chloride channel protein 2

1

0

High-throughput

0.656

High

353470

NOX4
NADPH oxidase 4

1

0

High-throughput

0.656

High

353476

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

0

High-throughput

0.656

High

353381

ITPI2
Protein ITPRID2

3

0

High-throughput

0.638

High

198336

KLK10
Kallikrein-10

1

2

High-throughput

0.618

High

353461

EGFL8
Epidermal growth factor-like protein 8

1

3

High-throughput

0.618

High

353364

PIGR
Polymeric immunoglobulin receptor

1

17

Small-scale

0.618

High

353370

GROA
Growth-regulated alpha protein

1

2

Small-scale

0.618

High

353372

IL8
Interleukin-8

1

2

Small-scale

0.618

High

353387

CXCL5
C-X-C motif chemokine 5

1

2

Small-scale

0.618

High

353392

LUM
Lumican

1

1

Small-scale

0.618

High

353414

SCRIB
Protein scribble homolog

1

2

Small-scale

0.618

High

353377

RAB3B
Ras-related protein Rab-3B

1

0

Small-scale

0.614

High

60267

POTEF
POTE ankyrin domain family member F

1

0

Small-scale

0.586

High

133819

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.586

High

353368

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.586

High

353374

CCL5
C-C motif chemokine 5

1

0

Small-scale

0.586

High

353404

NOTC2
Neurogenic locus notch homolog protein 2

1

0

Small-scale

0.586

High

353376

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.578

High

353389

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.578

High

353391

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

0

High-throughput

0.578

High

353402

CDK6
Cyclin-dependent kinase 6

1

0

High-throughput

0.578

High

353422

T176B
Transmembrane protein 176B

1

0

High-throughput

0.578

High

353432

SPNS3
Protein spinster homolog 3

1

0

High-throughput

0.578

High

353469

COE2
Transcription factor COE2

1

0

High-throughput

0.578

High

353425

HBM
Hemoglobin subunit mu

2

1

High-throughput

0.574

High

353440

FRMD1
FERM domain-containing protein 1

2

7

High-throughput

0.574

High

353457

SNX27
Sorting nexin-27

2

3

High-throughput

0.574

High

353394

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.553

High

353413

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.553

High

353449

MK15
Mitogen-activated protein kinase 15

1

3

High-throughput

0.553

High

353478

NINL
Ninein-like protein

1

1

High-throughput

0.553

High

353456

LOXL4
Lysyl oxidase homolog 4

1

3

High-throughput

0.536

High

353393

SC24C
Protein transport protein Sec24C

1

0

Small-scale

0.517

High

353436

PRS58
Serine protease 58

1

0

Small-scale

0.517

High

353445

KMT2C
Histone-lysine N-methyltransferase 2C

1

0

Small-scale

0.517

High

353410

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.514

High

168486

SCAM2
Secretory carrier-associated membrane protein 2

1

0

High-throughput

0.513

High

353443

AT11C
Phospholipid-transporting ATPase IG

1

0

High-throughput

0.513

High

353452

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

353454

PMEPA
Protein TMEPAI

1

0

High-throughput

0.513

High

353471

GKN1
Gastrokine-1

1

0

High-throughput

0.513

High

353369

HBAT
Hemoglobin subunit theta-1

1

1

High-throughput

0.489

High

353406

RING1
E3 ubiquitin-protein ligase RING1

1

1

High-throughput

0.489

High

353433

AEBP2
Zinc finger protein AEBP2

1

1

High-throughput

0.489

High

353451

ZDH19
Palmitoyltransferase ZDHHC19

1

1

High-throughput

0.489

High

353475

KLF15
Krueppel-like factor 15

1

1

High-throughput

0.489

High

353375

K1C10
Keratin, type I cytoskeletal 10

1

1

Small-scale

0.479

High

353384

K1C9
Keratin, type I cytoskeletal 9

1

1

Small-scale

0.479

High

353385

K22E
Keratin, type II cytoskeletal 2 epidermal

1

1

Small-scale

0.479

High

353388

EFTU
Elongation factor Tu, mitochondrial

1

1

Small-scale

0.479

High

353416

NUMA1
Nuclear mitotic apparatus protein 1

1

1

Small-scale

0.479

High

353446

NBEA
Neurobeachin

1

1

Small-scale

0.479

High

353460

RANB9
Ran-binding protein 9

1

2

High-throughput

0.479

High

353479

E41L3
Band 4.1-like protein 3

1

3

Small-scale

0.479

High

58777

T131L
Transmembrane protein 131-like

1

0

Small-scale

0.458

High

353365

K2C1
Keratin, type II cytoskeletal 1

1

0

Small-scale

0.458

High

353367

TBB5
Tubulin beta chain

1

0

Small-scale

0.458

High

353378

FLNA
Filamin-A

1

0

Small-scale

0.458

High

353379

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

Small-scale

0.458

High

353398

H4
Histone H4

1

0

Small-scale

0.458

High

353399

RL11
Large ribosomal subunit protein uL5

1

0

Small-scale

0.458

High

353407

PRDX1
Peroxiredoxin-1

1

0

Small-scale

0.458

High

353366

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

4

Small-scale

0.437

High

353373

PYC
Pyruvate carboxylase, mitochondrial

1

4

Small-scale

0.437

High

353380

LAMA2
Laminin subunit alpha-2

1

11

Small-scale

0.437

High

353400

TBA1B
Tubulin alpha-1B chain

1

1

Small-scale

0.437

High

353403

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.437

High

353411

ACACA
Acetyl-CoA carboxylase 1

1

4

Small-scale

0.437

High

353412

CUL4A
Cullin-4A

1

4

High-throughput

0.437

High

353431

RFIP1
Rab11 family-interacting protein 1

1

1

Small-scale

0.437

High

353434

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.437

High

353448

LNX1
E3 ubiquitin-protein ligase LNX

1

6

Small-scale

0.437

High

353459

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

Small-scale

0.437

High

353464

RFIP5
Rab11 family-interacting protein 5

1

2

Small-scale

0.437

High

353465

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.437

High

353401

TF2B
Transcription initiation factor IIB

3

0

High-throughput

0.347

High

353424

ICE2
Little elongation complex subunit 2

3

0

High-throughput

0.347

High

353458

TM237
Transmembrane protein 237

3

0

High-throughput

0.347

High

353447

NPB
Neuropeptide B

2

0

High-throughput

0.328

High

64476

GOG8A
Golgin subfamily A member 8A

1

0

High-throughput

0.279

Low

127085

FOXN3
Forkhead box protein N3

1

0

High-throughput

0.279

Low

180529

MAGB4
Melanoma-associated antigen B4

1

0

High-throughput

0.279

Low

312691

CXB5
Gap junction beta-5 protein

1

0

High-throughput

0.279

Low

330377

CX001
Putative transmembrane protein CXorf1

1

0

High-throughput

0.279

Low

353396

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

353397

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.279

Low

353409

TWF1
Twinfilin-1

1

0

High-throughput

0.279

Low

353415

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.279

Low

353419

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

0

High-throughput

0.279

Low

353420

PKHG6
Pleckstrin homology domain-containing family G member 6

1

0

High-throughput

0.279

Low

353427

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

353429

SFXN4
Sideroflexin-4

1

0

High-throughput

0.279

Low

353430

PBIR3
PABIR family member 1

1

0

High-throughput

0.279

Low

353435

ZN695
Zinc finger protein 695

1

0

High-throughput

0.279

Low

353437

RIBC1
RIB43A-like with coiled-coils protein 1

1

0

High-throughput

0.279

Low

353438

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.279

Low

353439

CJ053
UPF0728 protein C10orf53

1

0

High-throughput

0.279

Low

353441

ZN491
Zinc finger protein 491

1

0

High-throughput

0.279

Low

353450

CHAC2
Glutathione-specific gamma-glutamylcyclotransferase 2

1

0

High-throughput

0.279

Low

353453

CRGN
Gamma-crystallin N

1

0

High-throughput

0.279

Low

353462

USB1
U6 snRNA phosphodiesterase 1

1

0

High-throughput

0.279

Low

353463

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.279

Low

353472

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

1

0

High-throughput

0.279

Low

353477

NXT1
NTF2-related export protein 1

1

0

High-throughput

0.279

Low

353466

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.269

Low

206935

SMAD6
Mothers against decapentaplegic homolog 6

1

0

Small-scale

0.249

Low

212342

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.249

Low

224258

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.249

Low

260430

PITX3
Pituitary homeobox 3

1

0

Small-scale

0.249

Low

304677

ZN202
Zinc finger protein 202

1

0

Small-scale

0.249

Low

353382

PML
Protein PML

1

0

High-throughput

0.249

Low

353383

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

0

Small-scale

0.249

Low

353405

EF1A2
Elongation factor 1-alpha 2

1

0

Small-scale

0.249

Low

353408

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.249

Low

353417

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.249

Low

353421

UD3A2
UDP-glucuronosyltransferase 3A2

1

0

Small-scale

0.249

Low

353423

KCD21
BTB/POZ domain-containing protein KCTD21

1

0

Small-scale

0.249

Low

353428

TATD1
Deoxyribonuclease TATDN1

1

0

Small-scale

0.249

Low

353444

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

353468

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.249

Low

353473

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

353474

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024