Protein: CD3E
T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)

Gene: CD3E
Organism: Homo sapiens
Interactions: 67
UniProt ID: P07766

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0001954 - positive regulation of cell-matrix adhesion
GO:0002250 - adaptive immune response
GO:0002669 - positive regulation of T cell anergy
GO:0002870 - T cell anergy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

430677

CD3G
T-cell surface glycoprotein CD3 gamma chain

2

1

Small-scale

0.737

High

208975

NCK2
Cytoplasmic protein NCK2

4

5

Small-scale

0.691

High

430690

ZAP70
Tyrosine-protein kinase ZAP-70

4

4

Small-scale

0.686

High

430679

NCK1
SH2/SH3 adapter protein NCK1

3

4

Small-scale

0.684

High

430713

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

2

6

Small-scale

0.654

High

430706

GHDC
GH3 domain-containing protein

3

0

High-throughput

0.638

High

430727

LCAP
Leucyl-cystinyl aminopeptidase

3

0

High-throughput

0.638

High

430691

KSYK
Tyrosine-protein kinase SYK

2

3

Small-scale

0.611

High

430678

GP1BB
Platelet glycoprotein Ib beta chain

2

0

High-throughput

0.585

High

430719

TM2D3
TM2 domain-containing protein 3

2

0

High-throughput

0.585

High

430683

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

1

Small-scale

0.584

High

305342

ZFPL1
Zinc finger protein-like 1

2

0

High-throughput

0.580

High

430698

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

2

0

High-throughput

0.580

High

430707

MUC15
Mucin-15

2

0

High-throughput

0.580

High

430718

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

2

0

High-throughput

0.580

High

380354

CD3D
T-cell surface glycoprotein CD3 delta chain

1

1

Small-scale

0.575

High

382265

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

0

High-throughput

0.547

High

411550

LCK
Tyrosine-protein kinase Lck

2

0

Small-scale

0.547

High

179521

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

Small-scale

0.537

High

430730

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

1

Small-scale

0.536

High

58785

T131L
Transmembrane protein 131-like

1

0

High-throughput

0.513

High

233046

FZD6
Frizzled-6

1

0

High-throughput

0.513

High

281507

WFS1
Wolframin

1

0

High-throughput

0.513

High

430687

TGFR1
TGF-beta receptor type-1

1

0

High-throughput

0.513

High

430688

SCNNA
Amiloride-sensitive sodium channel subunit alpha

1

0

High-throughput

0.513

High

430694

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

0

High-throughput

0.513

High

430701

MBRL
Membralin

1

0

High-throughput

0.513

High

430705

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

0

High-throughput

0.513

High

430708

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.513

High

430709

VANG1
Vang-like protein 1

1

0

High-throughput

0.513

High

430710

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.513

High

430716

ASTRA
Protein Aster-A

1

0

High-throughput

0.513

High

430723

CC50A
Cell cycle control protein 50A

1

0

High-throughput

0.513

High

430725

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.513

High

430726

COPG2
Coatomer subunit gamma-2

1

0

High-throughput

0.513

High

430689

CSK
Tyrosine-protein kinase CSK

1

1

Small-scale

0.501

High

430680

NUCL
Nucleolin

1

0

Small-scale

0.480

High

430692

JAK3
Tyrosine-protein kinase JAK3

1

5

Small-scale

0.479

High

430697

EPS8
Epidermal growth factor receptor kinase substrate 8

1

5

Small-scale

0.479

High

430712

ES8L3
Epidermal growth factor receptor kinase substrate 8-like protein 3

1

5

Small-scale

0.479

High

430722

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

6

Small-scale

0.479

High

430696

Q08AM2
ADAM33 protein

1

1

High-throughput

0.470

High

207413

LAT
Linker for activation of T-cells family member 1

1

0

Small-scale

0.458

High

282177

NCTR1
Natural cytotoxicity triggering receptor 1

1

0

Small-scale

0.458

High

430676

LEG1
Galectin-1

1

0

Small-scale

0.458

High

430681

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

Small-scale

0.458

High

430684

CD38
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

1

0

Small-scale

0.458

High

430685

SHC1
SHC-transforming protein 1

1

5

Small-scale

0.445

High

430721

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

1

High-throughput

0.439

High

430686

CCR7
C-C chemokine receptor type 7

1

0

Small-scale

0.438

High

129167

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

4

Small-scale

0.437

High

430717

F241B
Protein FAM241B

3

0

High-throughput

0.347

High

430702

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

2

0

High-throughput

0.318

High

430693

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

0

Small-scale

0.292

High

430695

TOP2B
DNA topoisomerase 2-beta

1

0

Small-scale

0.292

High

430682

CRYGS
Gamma-crystallin S

1

0

High-throughput

0.279

Low

430700

D19L1
Protein C-mannosyl-transferase DPY19L1

1

0

High-throughput

0.279

Low

430703

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

430704

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.279

Low

430711

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.279

Low

430714

GPX8
Probable glutathione peroxidase 8

1

0

High-throughput

0.279

Low

430715

BRI3B
BRI3-binding protein

1

0

High-throughput

0.279

Low

430720

T106C
Transmembrane protein 106C

1

0

High-throughput

0.279

Low

430724

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

430728

TM59L
Transmembrane protein 59-like

1

0

High-throughput

0.279

Low

430729

DJC16
DnaJ homolog subfamily C member 16

1

0

High-throughput

0.279

Low

430699

SNTA1
Alpha-1-syntrophin

1

0

Small-scale

0.275

Low


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Last updated: 15 Jul 2024