Protein: HLAG
HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)]

Gene: HLAG, HLA-G
Organism: Homo sapiens
Interactions: 123
UniProt ID: P17693

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001915 - negative regulation of T cell mediated cytotoxicity
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002451 - peripheral B cell tolerance induction
GO:0002476 - antigen processing and presentation of endogenous peptide antigen via MHC class Ib

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

570343

LIRB2
Leukocyte immunoglobulin-like receptor subfamily B member 2

7

20

Small-scale

0.962

High

570304

HLAG
HLA class I histocompatibility antigen, alpha chain G

6

16

Small-scale

0.941

High

570351

LIRB1
Leukocyte immunoglobulin-like receptor subfamily B member 1

4

20

Small-scale

0.906

High

570316

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

4

19

Small-scale

0.867

High

488119

HLAC
HLA class I histocompatibility antigen, C alpha chain

3

16

High-throughput

0.861

High

382299

HLAA
HLA class I histocompatibility antigen, A alpha chain

3

15

High-throughput

0.847

High

353329

CD8A
T-cell surface glycoprotein CD8 alpha chain

3

3

Small-scale

0.840

High

533121

HLAE
HLA class I histocompatibility antigen, alpha chain E

2

16

High-throughput

0.811

High

570306

HLAF
HLA class I histocompatibility antigen, alpha chain F

2

16

High-throughput

0.811

High

570369

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

2

20

Small-scale

0.768

High

354281

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

15

High-throughput

0.712

High

299553

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

3

High-throughput

0.691

High

354670

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

18

High-throughput

0.691

High

355013

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

19

High-throughput

0.691

High

382580

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

20

High-throughput

0.691

High

570307

TGFR1
TGF-beta receptor type-1

1

2

High-throughput

0.691

High

570318

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

18

High-throughput

0.691

High

570319

IDD
Integral membrane protein DGCR2/IDD

1

5

High-throughput

0.691

High

570341

ANR46
Ankyrin repeat domain-containing protein 46

1

4

High-throughput

0.691

High

570350

CADM4
Cell adhesion molecule 4

1

3

High-throughput

0.691

High

570355

NEUFC
Neuferricin

1

2

High-throughput

0.691

High

570359

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

4

High-throughput

0.691

High

570360

HMR1
Major histocompatibility complex class I-related gene protein

1

16

High-throughput

0.691

High

570367

HPLN3
Hyaluronan and proteoglycan link protein 3

1

1

High-throughput

0.691

High

570381

MRC2
C-type mannose receptor 2

1

11

High-throughput

0.691

High

570388

JAG2
Protein jagged-2

1

1

High-throughput

0.691

High

570394

ST14
Suppressor of tumorigenicity 14 protein

1

12

High-throughput

0.691

High

570310

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.618

High

570311

KI3L1
Killer cell immunoglobulin-like receptor 3DL1

1

20

Small-scale

0.618

High

570328

IL27B
Interleukin-27 subunit beta

1

2

Small-scale

0.618

High

570332

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

4

High-throughput

0.618

High

354631

HLAH
Putative HLA class I histocompatibility antigen, alpha chain H

1

15

High-throughput

0.575

High

354928

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

20

High-throughput

0.575

High

441172

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

4

Small-scale

0.575

High

570305

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

20

Small-scale

0.575

High

570371

PXL2A
Peroxiredoxin-like 2A

2

1

High-throughput

0.574

High

368943

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

58791

T131L
Transmembrane protein 131-like

1

3

High-throughput

0.536

High

152250

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

12

High-throughput

0.536

High

165158

PLXB2
Plexin-B2

1

8

High-throughput

0.536

High

258295

LRP5
Low-density lipoprotein receptor-related protein 5

1

1

High-throughput

0.536

High

260219

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

2

High-throughput

0.536

High

270262

LRP6
Low-density lipoprotein receptor-related protein 6

1

1

High-throughput

0.536

High

327262

NOE2
Noelin-2

1

1

High-throughput

0.536

High

330452

CLPT1
Putative lipid scramblase CLPTM1

1

1

High-throughput

0.536

High

518081

ADT1
ADP/ATP translocase 1

1

1

High-throughput

0.536

High

536164

PERF
Perforin-1

1

1

High-throughput

0.536

High

570308

SCNNA
Amiloride-sensitive sodium channel subunit alpha

1

8

High-throughput

0.536

High

570309

ECE1
Endothelin-converting enzyme 1

1

4

High-throughput

0.536

High

570312

MA2A2
Alpha-mannosidase 2x

1

1

High-throughput

0.536

High

570313

PLXA3
Plexin-A3

1

7

High-throughput

0.536

High

570317

ASIC1
Acid-sensing ion channel 1

1

8

High-throughput

0.536

High

570320

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

18

High-throughput

0.536

High

570325

S39A6
Zinc transporter ZIP6

1

5

High-throughput

0.536

High

570326

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.536

High

570329

MBTP1
Membrane-bound transcription factor site-1 protease

1

3

High-throughput

0.536

High

570330

PON2
Serum paraoxonase/arylesterase 2

1

2

High-throughput

0.536

High

570335

AGRF1
Adhesion G-protein coupled receptor F1

1

3

High-throughput

0.536

High

570337

SE1L3
Protein sel-1 homolog 3

1

1

High-throughput

0.536

High

570338

CNNM4
Metal transporter CNNM4

1

3

High-throughput

0.536

High

570339

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

1

High-throughput

0.536

High

570340

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

3

High-throughput

0.536

High

570342

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

1

High-throughput

0.536

High

570346

UXS1
UDP-glucuronic acid decarboxylase 1

1

2

High-throughput

0.536

High

570347

CHSTE
Carbohydrate sulfotransferase 14

1

3

High-throughput

0.536

High

570348

DIK2A
Divergent protein kinase domain 2A

1

1

High-throughput

0.536

High

570349

NLGN2
Neuroligin-2

1

1

High-throughput

0.536

High

570353

GPX8
Probable glutathione peroxidase 8

1

1

High-throughput

0.536

High

570357

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

2

High-throughput

0.536

High

570358

TM131
Transmembrane protein 131

1

4

High-throughput

0.536

High

570362

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

2

High-throughput

0.536

High

570363

ARSG
Arylsulfatase G

1

1

High-throughput

0.536

High

570368

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

4

High-throughput

0.536

High

570370

CSTN3
Calsyntenin-3

1

6

High-throughput

0.536

High

570374

SEM6B
Semaphorin-6B

1

2

High-throughput

0.536

High

570376

CHSTC
Carbohydrate sulfotransferase 12

1

3

High-throughput

0.536

High

570377

SEM4G
Semaphorin-4G

1

4

High-throughput

0.536

High

570379

CC50A
Cell cycle control protein 50A

1

5

High-throughput

0.536

High

570384

PLXA1
Plexin-A1

1

6

High-throughput

0.536

High

570386

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

12

High-throughput

0.536

High

570387

GBRT
Gamma-aminobutyric acid receptor subunit theta

1

5

High-throughput

0.536

High

570389

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

4

High-throughput

0.536

High

570391

MAN1
Inner nuclear membrane protein Man1

1

1

High-throughput

0.536

High

570393

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

2

High-throughput

0.536

High

570395

AGRG1
Adhesion G-protein coupled receptor G1

1

3

High-throughput

0.536

High

570336

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.517

High

199446

SPIT1
Kunitz-type protease inhibitor 1

1

0

High-throughput

0.513

High

230117

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

0

High-throughput

0.513

High

233052

FZD6
Frizzled-6

1

0

High-throughput

0.513

High

570323

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

570324

MSLN
Mesothelin

1

0

High-throughput

0.513

High

570331

SGCB
Beta-sarcoglycan

1

0

High-throughput

0.513

High

570354

PIGO
GPI ethanolamine phosphate transferase 3

1

0

High-throughput

0.513

High

570356

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.513

High

570361

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.513

High

570365

H6ST2
Heparan-sulfate 6-O-sulfotransferase 2

1

0

High-throughput

0.513

High

570373

OSBL8
Oxysterol-binding protein-related protein 8

1

0

High-throughput

0.513

High

570375

MER34
Endogenous retroviral envelope protein HEMO

1

0

High-throughput

0.513

High

570382

SUSD2
Sushi domain-containing protein 2

1

0

High-throughput

0.513

High

570385

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.513

High

570315

CDC42
Cell division control protein 42 homolog

1

18

High-throughput

0.501

High

299630

SUN1
SUN domain-containing protein 1

1

1

High-throughput

0.489

High

570333

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

5

High-throughput

0.489

High

570334

MKS3
Meckelin

1

1

High-throughput

0.489

High

570345

TTC13
Tetratricopeptide repeat protein 13

1

1

High-throughput

0.489

High

570364

BSCL2
Seipin

1

1

High-throughput

0.489

High

570366

LMF1
Lipase maturation factor 1

1

1

High-throughput

0.489

High

570383

SUN2
SUN domain-containing protein 2

1

1

High-throughput

0.489

High

570390

DJC16
DnaJ homolog subfamily C member 16

1

9

High-throughput

0.489

High

570392

TBL2
Transducin beta-like protein 2

1

1

High-throughput

0.489

High

500986

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.479

High

570314

COPB
Coatomer subunit beta

1

1

Small-scale

0.479

High

570321

TAP1
Antigen peptide transporter 1

1

9

Small-scale

0.479

High

570322

TAP2
Antigen peptide transporter 2

1

8

Small-scale

0.479

High

570372

CNPY3
Protein canopy homolog 3

1

1

Small-scale

0.479

High

555285

H2AX
Histone H2AX

1

1

Small-scale

0.437

High

72709

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

0

High-throughput

0.279

Low

570327

LAMB3
Laminin subunit beta-3

1

0

High-throughput

0.279

Low

570344

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

570352

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.279

Low

570378

TM39A
Transmembrane protein 39A

1

0

High-throughput

0.279

Low

570380

P4HTM
Transmembrane prolyl 4-hydroxylase

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024