Protein: FIS1
Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11)

Gene: FIS1
Organism: Homo sapiens
Interactions: 206
UniProt ID: Q9Y3D6

Gene Ontology (top 5):
GO:0000266 - mitochondrial fission
GO:0000422 - autophagy of mitochondrion
GO:0001836 - release of cytochrome c from mitochondria
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

128674

DNM1L
Dynamin-1-like protein

4

5

Small-scale

0.694

High

1343483

MID51
Mitochondrial dynamics protein MIEF1

3

0

Small-scale

0.628

High

1253228

TBC15
TBC1 domain family member 15

3

2

Small-scale

0.615

High

1301082

VP13A
Intermembrane lipid transfer protein VPS13A

2

2

High-throughput

0.611

High

1334647

TBC17
TBC1 domain family member 17

2

2

High-throughput

0.611

High

183312

FFAR2
Free fatty acid receptor 2

2

0

High-throughput

0.580

High

883086

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

2

0

High-throughput

0.580

High

1068390

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.580

High

1160119

RNK
Ribonuclease kappa

2

0

High-throughput

0.580

High

1170497

TMPPE
Transmembrane protein with metallophosphoesterase domain

2

0

High-throughput

0.580

High

1234005

EMC5
ER membrane protein complex subunit 5

2

0

High-throughput

0.580

High

1234956

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

1285545

APH1A
Gamma-secretase subunit APH-1A

2

0

High-throughput

0.580

High

1296529

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.580

High

1313419

ABHD6
Monoacylglycerol lipase ABHD6

2

0

High-throughput

0.580

High

1348254

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.580

High

1377088

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.580

High

1377665

FIS1
Mitochondrial fission 1 protein

1

1

Small-scale

0.575

High

847736

BAP31
B-cell receptor-associated protein 31

1

0

Small-scale

0.571

High

216876

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

1335702

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

0

Small-scale

0.549

High

840348

PEX5
Peroxisomal targeting signal 1 receptor

2

0

Small-scale

0.539

High

505506

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.536

High

538825

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

1

High-throughput

0.536

High

1282101

RAB24
Ras-related protein Rab-24

1

1

High-throughput

0.536

High

1357760

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

1

High-throughput

0.536

High

1377666

RBGP1
Rab GTPase-activating protein 1

1

2

High-throughput

0.536

High

258280

PX11A
Peroxisomal membrane protein 11A

1

3

Small-scale

0.515

High

330797

PX11B
Peroxisomal membrane protein 11B

1

3

Small-scale

0.515

High

1293338

PX11C
Peroxisomal membrane protein 11C

1

3

Small-scale

0.515

High

213780

MCAT
Mitochondrial carnitine/acylcarnitine carrier protein

1

0

High-throughput

0.513

High

871984

AT12A
Potassium-transporting ATPase alpha chain 2

1

0

High-throughput

0.513

High

895394

RAB5B
Ras-related protein Rab-5B

1

0

High-throughput

0.513

High

896700

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.513

High

1059403

CASP8
Caspase-8

1

0

Small-scale

0.513

High

1219144

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1233072

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1266066

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

1266607

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.513

High

1282897

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.513

High

1295256

SPTCS
Spatacsin

1

0

High-throughput

0.513

High

1334803

NJMU
Protein Njmu-R1

1

0

High-throughput

0.513

High

1342386

RAB18
Ras-related protein Rab-18

1

0

High-throughput

0.513

High

1347767

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.493

High

1136967

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

1

1

High-throughput

0.489

High

1150003

BLT3A
Bridge-like lipid transfer protein family member 3A

1

2

High-throughput

0.489

High

1286942

EVI5L
EVI5-like protein

1

1

High-throughput

0.489

High

1309542

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.489

High

667739

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.486

High

173324

S22A2
Solute carrier family 22 member 2

1

1

Small-scale

0.481

High

173354

S22A1
Solute carrier family 22 member 1

1

1

Small-scale

0.481

High

180959

YKT6
Synaptobrevin homolog YKT6

1

1

High-throughput

0.479

High

196902

CYB5B
Cytochrome b5 type B

1

1

High-throughput

0.479

High

218089

PEX1
Peroxisomal ATPase PEX1

1

3

High-throughput

0.479

High

229139

PRKN
E3 ubiquitin-protein ligase parkin

1

2

Small-scale

0.479

High

264658

MTX2
Metaxin-2

1

1

High-throughput

0.479

High

297115

TOM70
Mitochondrial import receptor subunit TOM70

1

1

High-throughput

0.479

High

310874

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.479

High

415548

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.479

High

476614

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.479

High

533889

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

High-throughput

0.479

High

568841

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

High-throughput

0.479

High

583384

HXK1
Hexokinase-1

1

1

High-throughput

0.479

High

679415

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

1

High-throughput

0.479

High

777288

PEX19
Peroxisomal biogenesis factor 19

1

1

High-throughput

0.479

High

856262

HXK2
Hexokinase-2

1

1

High-throughput

0.479

High

1040782

PEX6
Peroxisomal ATPase PEX6

1

2

High-throughput

0.479

High

1053268

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

High-throughput

0.479

High

1072896

MTFR1
Mitochondrial fission regulator 1

1

2

High-throughput

0.479

High

1079476

VAMP3
Vesicle-associated membrane protein 3

1

1

High-throughput

0.479

High

1126198

MTX3
Metaxin-3

1

1

High-throughput

0.479

High

1130758

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

Small-scale

0.479

High

1136990

VP13D
Intermembrane lipid transfer protein VPS13D

1

2

High-throughput

0.479

High

1159613

MTFR2
Mitochondrial fission regulator 2

1

2

High-throughput

0.479

High

1184505

ARMX2
Armadillo repeat-containing X-linked protein 2

1

2

High-throughput

0.479

High

1205090

VRK2
Serine/threonine-protein kinase VRK2

1

1

High-throughput

0.479

High

1231559

ARM10
Armadillo repeat-containing protein 10

1

2

High-throughput

0.479

High

1234766

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

1

High-throughput

0.479

High

1240543

ATAD1
Outer mitochondrial transmembrane helix translocase

1

2

High-throughput

0.479

High

1267633

UBXN4
UBX domain-containing protein 4

1

1

High-throughput

0.479

High

1268990

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

1287234

FAF2
FAS-associated factor 2

1

1

High-throughput

0.479

High

1293084

MYO19
Unconventional myosin-XIX

1

1

High-throughput

0.479

High

1303131

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.479

High

1305067

TTC1
Tetratricopeptide repeat protein 1

1

1

High-throughput

0.479

High

1327092

MFR1L
Mitochondrial fission regulator 1-like

1

2

High-throughput

0.479

High

1348847

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

1

High-throughput

0.479

High

1349737

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

1

High-throughput

0.479

High

1355216

ARMX3
Armadillo repeat-containing X-linked protein 3

1

2

High-throughput

0.479

High

1377452

TDRKH
Tudor and KH domain-containing protein

1

1

High-throughput

0.479

High

1377667

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.479

High

1309384

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.460

High

58174

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.458

High

130632

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

258563

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

264123

TACC1
Transforming acidic coiled-coil-containing protein 1

1

0

High-throughput

0.458

High

275147

RENR
Renin receptor

1

0

High-throughput

0.458

High

307677

STBD1
Starch-binding domain-containing protein 1

1

0

High-throughput

0.458

High

391274

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

573985

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

579633

ATP5J
ATP synthase-coupling factor 6, mitochondrial

1

0

High-throughput

0.458

High

607745

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.458

High

623887

KPCL
Protein kinase C eta type

1

0

High-throughput

0.458

High

657454

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.458

High

686211

GLPK
Glycerol kinase

1

0

High-throughput

0.458

High

725911

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.458

High

803820

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.458

High

825610

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

845371

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

849008

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

862496

ACLY
ATP-citrate synthase

1

0

High-throughput

0.458

High

881699

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

993093

RHG01
Rho GTPase-activating protein 1

1

0

High-throughput

0.458

High

1032891

PHLP
Phosducin-like protein

1

0

High-throughput

0.458

High

1037020

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1040310

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1040963

MTMR3
Myotubularin-related protein 3

1

0

High-throughput

0.458

High

1042900

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1052515

FLOT2
Flotillin-2

1

0

High-throughput

0.458

High

1062721

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

1065462

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.458

High

1079867

VAS1
V-type proton ATPase subunit S1

1

0

High-throughput

0.458

High

1088707

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

1135167

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1136108

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.458

High

1138763

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.458

High

1144519

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.458

High

1173941

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

High-throughput

0.458

High

1187871

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

High-throughput

0.458

High

1190134

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.458

High

1199913

KTN1
Kinectin

1

0

High-throughput

0.458

High

1204621

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.458

High

1218544

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1220712

MIRO2
Mitochondrial Rho GTPase 2

1

0

High-throughput

0.458

High

1237043

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

1239131

MIGA1
Mitoguardin 1

1

0

High-throughput

0.458

High

1242521

EHBP1
EH domain-binding protein 1

1

0

High-throughput

0.458

High

1243453

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

1251993

GDAP1
Ganglioside-induced differentiation-associated protein 1

1

0

Small-scale

0.458

High

1260678

CHMP7
Charged multivesicular body protein 7

1

0

High-throughput

0.458

High

1270003

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1283338

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.458

High

1283535

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.458

High

1283985

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.458

High

1287445

OPTN
Optineurin

1

0

High-throughput

0.458

High

1294168

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1297425

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1301883

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.458

High

1302282

TM209
Transmembrane protein 209

1

0

High-throughput

0.458

High

1303207

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1305197

CDCA3
Cell division cycle-associated protein 3

1

0

High-throughput

0.458

High

1308571

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.458

High

1311461

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

1315449

B2L13
Bcl-2-like protein 13

1

0

High-throughput

0.458

High

1326921

MFF
Mitochondrial fission factor

1

0

High-throughput

0.458

High

1327331

LSG1
Large subunit GTPase 1 homolog

1

0

High-throughput

0.458

High

1329597

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.458

High

1330284

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.458

High

1335831

SENP2
Sentrin-specific protease 2

1

0

High-throughput

0.458

High

1336326

GPAT1
Glycerol-3-phosphate acyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1344422

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1346530

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1346565

DJC11
DnaJ homolog subfamily C member 11

1

0

High-throughput

0.458

High

1347740

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1349567

EMC3
ER membrane protein complex subunit 3

1

0

High-throughput

0.458

High

1355226

MLX
Max-like protein X

1

0

High-throughput

0.458

High

1355371

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

1356351

FBXL4
F-box/LRR-repeat protein 4

1

0

High-throughput

0.458

High

1356860

PALD
Paladin

1

0

High-throughput

0.458

High

1377416

MAN1
Inner nuclear membrane protein Man1

1

0

High-throughput

0.458

High

1377668

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.458

High

263399

SC22B
Vesicle-trafficking protein SEC22b

1

1

High-throughput

0.437

High

331358

CHK2
Serine/threonine-protein kinase Chk2

1

1

High-throughput

0.437

High

816206

KCNJ6
G protein-activated inward rectifier potassium channel 2

2

0

High-throughput

0.316

High

1032073

UT1
Urea transporter 1

2

0

High-throughput

0.316

High

1108664

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.316

High

1128755

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

1345971

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

1236106

KASH5
Protein KASH5

1

0

High-throughput

0.299

High

126556

QSOX1
Sulfhydryl oxidase 1

1

0

High-throughput

0.279

Low

1033068

TARB1
Probable methyltransferase TARBP1

1

0

High-throughput

0.279

Low

1127240

DYLT4
Dynein light chain Tctex-type 4

1

0

High-throughput

0.279

Low

1145651

F91A1
Protein FAM91A1

1

0

High-throughput

0.279

Low

1148040

ZFY26
Zinc finger FYVE domain-containing protein 26

1

0

High-throughput

0.279

Low

1149537

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.279

Low

1237229

CCYL1
Cyclin-Y-like protein 1

1

0

High-throughput

0.279

Low

1312196

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.279

Low

1334989

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.279

Low

1377034

PLAP
Phospholipase A-2-activating protein

1

0

High-throughput

0.279

Low

344603

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.251

Low

1037776

AQP6
Aquaporin-6

1

0

High-throughput

0.251

Low

1377669

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.251

Low

236471

RNBP6
Ran-binding protein 6

1

0

High-throughput

0.249

Low

570214

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

877974

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

1100179

INF2
Inverted formin-2

1

0

High-throughput

0.249

Low

1114075

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.249

Low

1131041

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.249

Low

1172389

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1256844

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

High-throughput

0.249

Low

1318581

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.249

Low

1331104

TRABD
TraB domain-containing protein

1

0

High-throughput

0.249

Low

1334203

SPE39
Spermatogenesis-defective protein 39 homolog

1

0

High-throughput

0.249

Low

1334717

WDR41
WD repeat-containing protein 41

1

0

High-throughput

0.249

Low

321259

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024