Protein: SYSM
Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)

Gene: SYSM, SARS2
Organism: Homo sapiens
Interactions: 80
UniProt ID: Q9NP81

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003723 - RNA binding
GO:0004828 - serine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1342452

KCMF1
E3 ubiquitin-protein ligase KCMF1

4

0

Small-scale

0.664

High

1042599

CUL3
Cullin-3

2

9

High-throughput

0.611

High

1219026

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

4

High-throughput

0.611

High

1289620

FBX17
F-box only protein 17

2

1

High-throughput

0.611

High

1342458

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

1

Small-scale

0.611

High

228781

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

1293289

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

258803

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

2

High-throughput

0.536

High

1051103

ICT1
Large ribosomal subunit protein mL62

1

2

High-throughput

0.536

High

1085968

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.536

High

1133491

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

High-throughput

0.536

High

1232843

GUF1
Translation factor GUF1, mitochondrial

1

2

High-throughput

0.536

High

1342454

NPS3A
Protein NipSnap homolog 3A

1

3

High-throughput

0.536

High

841481

BPL1
Biotin--protein ligase

1

0

High-throughput

0.518

High

1342457

PUF60
Poly(U)-binding-splicing factor PUF60

1

2

High-throughput

0.515

High

59319

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.513

High

326353

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

0

High-throughput

0.513

High

1297470

IMP1L
Mitochondrial inner membrane protease subunit 1

1

0

High-throughput

0.513

High

175224

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.501

High

370494

ESR1
Estrogen receptor

1

3

Small-scale

0.501

High

476423

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

435772

IGF1R
Insulin-like growth factor 1 receptor

1

7

High-throughput

0.500

High

295282

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

298810

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

318023

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

4

High-throughput

0.479

High

374922

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

385562

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

438548

HS90B
Heat shock protein HSP 90-beta

1

10

High-throughput

0.479

High

440748

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.479

High

473419

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

1

High-throughput

0.479

High

500137

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

525650

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.479

High

780151

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

803244

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

829065

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

Small-scale

0.479

High

909161

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

927779

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

1

Small-scale

0.479

High

1041210

CUL1
Cullin-1

1

9

Small-scale

0.479

High

1045873

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1066736

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1068092

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1086806

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.479

High

1101307

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

1146859

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.479

High

1153937

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

1284531

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

1290508

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

3

High-throughput

0.479

High

1332645

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1333365

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

4

High-throughput

0.479

High

1342450

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

4

High-throughput

0.479

High

1342455

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

1342456

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

997672

DMWD
Dystrophia myotonica WD repeat-containing protein

1

5

High-throughput

0.470

High

1327643

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

1

3

High-throughput

0.470

High

224530

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

719627

MERL
Merlin

1

0

High-throughput

0.458

High

799373

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

921437

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

929071

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

1152978

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1183705

TM10C
tRNA methyltransferase 10 homolog C

1

0

Small-scale

0.458

High

1246526

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.458

High

1314211

TR61B
tRNA

1

0

High-throughput

0.458

High

1342451

AATF
Protein AATF

1

0

High-throughput

0.458

High

1342460

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

387563

P53
Cellular tumor antigen p53

1

3

Small-scale

0.445

High

402502

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

1036921

SQSTM
Sequestosome-1

1

2

High-throughput

0.445

High

1342459

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

3

High-throughput

0.445

High

262591

TULP3
Tubby-related protein 3

1

1

High-throughput

0.437

High

553786

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

721516

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1081411

E2F4
Transcription factor E2F4

1

1

High-throughput

0.437

High

1171824

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

1294029

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

1331359

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1049334

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.426

High

1342453

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

High-throughput

0.279

Low

877906

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

1251861

SPT20
Spermatogenesis-associated protein 20

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024