Protein: PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein)

Gene: PRPF3
Organism: Homo sapiens
Interactions: 238
UniProt ID: O43395

Gene Ontology (top 5):
GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0000375 - RNA splicing, via transesterification reactions
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

196912

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

7

4

Small-scale

0.965

High

202556

LSM4
U6 snRNA-associated Sm-like protein LSm4

4

8

High-throughput

0.895

High

202464

PRP8
Pre-mRNA-processing-splicing factor 8

4

1

Small-scale

0.890

High

202505

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

5

0

High-throughput

0.880

High

202370

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

3

2

High-throughput

0.871

High

202404

RUXF
Small nuclear ribonucleoprotein F

3

10

High-throughput

0.871

High

202409

SMD2
Small nuclear ribonucleoprotein Sm D2

3

3

High-throughput

0.871

High

202407

LSM6
U6 snRNA-associated Sm-like protein LSm6

3

10

High-throughput

0.861

High

202415

RSMN
Small nuclear ribonucleoprotein-associated protein N

3

2

High-throughput

0.861

High

202552

LSM2
U6 snRNA-associated Sm-like protein LSm2

3

7

High-throughput

0.861

High

202399

NH2L1
NHP2-like protein 1

3

0

Small-scale

0.819

High

202334

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

2

Small-scale

0.817

High

202403

RUXE
Small nuclear ribonucleoprotein E

2

1

High-throughput

0.811

High

202406

LSM3
U6 snRNA-associated Sm-like protein LSm3

2

8

High-throughput

0.811

High

202408

SMD1
Small nuclear ribonucleoprotein Sm D1

2

8

High-throughput

0.811

High

202555

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

9

High-throughput

0.811

High

202350

LSM8
U6 snRNA-associated Sm-like protein LSm8

2

10

High-throughput

0.789

High

202405

RUXG
Small nuclear ribonucleoprotein G

2

11

High-throughput

0.789

High

202547

PRP19
Pre-mRNA-processing factor 19

1

5

Small-scale

0.747

High

202440

SART3
Squamous cell carcinoma antigen recognized by T-cells 3

6

3

Small-scale

0.738

High

202378

U2AF2
Splicing factor U2AF 65 kDa subunit

4

5

High-throughput

0.704

High

202429

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

4

1

Small-scale

0.704

High

202530

TRI39
E3 ubiquitin-protein ligase TRIM39

5

0

High-throughput

0.697

High

202342

SF3B1
Splicing factor 3B subunit 1

1

1

High-throughput

0.691

High

202410

SMD3
Small nuclear ribonucleoprotein Sm D3

1

8

High-throughput

0.691

High

202416

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.691

High

202544

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

10

High-throughput

0.691

High

202469

MEPCE
7SK snRNA methylphosphate capping enzyme

5

0

High-throughput

0.684

High

202346

PRP6
Pre-mRNA-processing factor 6

3

2

Small-scale

0.681

High

202485

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

3

2

Small-scale

0.681

High

202483

FAM9B
Protein FAM9B

4

0

High-throughput

0.679

High

199616

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

4

0

Small-scale

0.675

High

202516

RBM42
RNA-binding protein 42

3

1

High-throughput

0.675

High

202496

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

3

2

Small-scale

0.669

High

202442

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

3

1

High-throughput

0.667

High

202472

CATAC
Centrosomal AT-AC splicing factor

4

0

Small-scale

0.664

High

202517

DDX23
Probable ATP-dependent RNA helicase DDX23

4

0

High-throughput

0.664

High

202554

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

3

1

Small-scale

0.662

High

202351

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

202437

RBM39
RNA-binding protein 39

3

0

High-throughput

0.636

High

202542

ZRAN1
Ubiquitin thioesterase ZRANB1

3

0

High-throughput

0.625

High

202546

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.618

High

202344

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

2

3

Small-scale

0.614

High

202541

AKA7G
A-kinase anchor protein 7 isoform gamma

2

1

High-throughput

0.611

High

202390

TXLNA
Alpha-taxilin

2

1

High-throughput

0.606

High

202419

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

2

1

High-throughput

0.606

High

202456

RN151
RING finger protein 151

2

1

High-throughput

0.606

High

202510

NACC1
Nucleus accumbens-associated protein 1

2

1

High-throughput

0.606

High

202476

FBX11
F-box only protein 11

2

0

High-throughput

0.602

High

202494

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

202527

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

2

0

High-throughput

0.602

High

202459

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

2

1

Small-scale

0.601

High

202513

CDC5L
Cell division cycle 5-like protein

2

0

Small-scale

0.592

High

202482

SRRM1
Serine/arginine repetitive matrix protein 1

1

0

High-throughput

0.586

High

202348

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

2

0

High-throughput

0.585

High

202389

COIL
Coilin

2

0

High-throughput

0.585

High

202448

SF3A2
Splicing factor 3A subunit 2

2

0

High-throughput

0.585

High

202366

ANDR
Androgen receptor

2

1

High-throughput

0.584

High

202481

SLX4
Structure-specific endonuclease subunit SLX4

2

1

High-throughput

0.584

High

202501

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

1

High-throughput

0.582

High

202340

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

202489

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.580

High

202495

FOG2
Zinc finger protein ZFPM2

2

0

High-throughput

0.580

High

202525

OSBL3
Oxysterol-binding protein-related protein 3

2

0

High-throughput

0.580

High

202550

ADIP
Afadin- and alpha-actinin-binding protein

2

0

High-throughput

0.580

High

68384

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

11

High-throughput

0.575

High

202397

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.573

High

202335

PPIH
Peptidyl-prolyl cis-trans isomerase H

2

0

Small-scale

0.561

High

202337

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

202412

H4
Histone H4

2

0

High-throughput

0.559

High

202417

ACTC
Actin, alpha cardiac muscle 1

2

0

High-throughput

0.559

High

202418

H31
Histone H3.1

2

0

High-throughput

0.559

High

202436

ELOA1
Elongin-A

2

0

Small-scale

0.559

High

202457

LARP7
La-related protein 7

2

0

High-throughput

0.559

High

202424

GOGA2
Golgin subfamily A member 2

2

1

High-throughput

0.553

High

202445

RABE1
Rab GTPase-binding effector protein 1

2

2

High-throughput

0.553

High

202345

SPF30
Survival of motor neuron-related-splicing factor 30

1

0

High-throughput

0.549

High

202347

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.549

High

202432

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.549

High

202486

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.549

High

198491

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.549

High

202479

PHC2
Polyhomeotic-like protein 2

1

0

High-throughput

0.549

High

202504

GASP2
G-protein coupled receptor-associated sorting protein 2

1

0

High-throughput

0.549

High

150776

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.541

High

202502

GTPB3
tRNA modification GTPase GTPBP3, mitochondrial

1

1

High-throughput

0.541

High

202360

RU2B
U2 small nuclear ribonucleoprotein B''

1

2

High-throughput

0.536

High

202362

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.536

High

202391

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

202421

TXN4A
Thioredoxin-like protein 4A

1

2

High-throughput

0.536

High

202433

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

1

High-throughput

0.536

High

202450

SF3A1
Splicing factor 3A subunit 1

1

1

High-throughput

0.536

High

202508

SPF45
Splicing factor 45

1

5

High-throughput

0.536

High

202532

TF7L2
Transcription factor 7-like 2

1

1

High-throughput

0.536

High

202538

TXN4B
Thioredoxin-like protein 4B

1

2

High-throughput

0.536

High

202543

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

2

High-throughput

0.523

High

202465

RHG36
Rho GTPase-activating protein 36

2

1

High-throughput

0.521

High

202452

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

202522

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.518

High

202446

RNPS1
RNA-binding protein with serine-rich domain 1

1

2

High-throughput

0.515

High

2654

A0A0C3SFZ9
FCH and mu domain containing endocytic adaptor 1

1

1

High-throughput

0.515

High

202462

Q6FI91
TSPYL protein

1

1

High-throughput

0.515

High

202363

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

202367

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

202387

FUS
RNA-binding protein FUS

1

0

High-throughput

0.513

High

202401

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

202425

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

202435

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.513

High

202449

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

0

High-throughput

0.513

High

202454

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

202500

KIFA3
Kinesin-associated protein 3

1

0

High-throughput

0.513

High

202534

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.513

High

202535

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

202447

PCBP1
Poly(rC)-binding protein 1

1

1

High-throughput

0.508

High

202343

WBP4
WW domain-binding protein 4

1

0

High-throughput

0.505

High

202468

F10C1
Protein FRA10AC1

1

0

High-throughput

0.486

High

202490

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.486

High

202497

CTBL1
Beta-catenin-like protein 1

1

0

High-throughput

0.486

High

147136

FCHO1
F-BAR domain only protein 1

1

1

High-throughput

0.481

High

202388

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.481

High

202503

ZBT8A
Zinc finger and BTB domain-containing protein 8A

1

2

High-throughput

0.481

High

202524

TSYL1
Testis-specific Y-encoded-like protein 1

1

1

High-throughput

0.481

High

202551

NINL
Ninein-like protein

1

2

High-throughput

0.481

High

133243

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

202339

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

202352

ESR1
Estrogen receptor

1

1

High-throughput

0.479

High

202354

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

202357

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.479

High

202364

H2A1
Histone H2A type 1

1

1

High-throughput

0.479

High

202372

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

202377

BRD2
Bromodomain-containing protein 2

1

4

High-throughput

0.479

High

202380

PML
Protein PML

1

2

High-throughput

0.479

High

202393

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.479

High

202423

ERCC6
DNA excision repair protein ERCC-6

1

2

Small-scale

0.479

High

202426

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

202428

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

202438

DHX8
ATP-dependent RNA helicase DHX8

1

1

High-throughput

0.479

High

202439

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

202441

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

202444

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.479

High

202455

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

202460

HABP4
Intracellular hyaluronan-binding protein 4

1

1

High-throughput

0.479

High

202463

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

202475

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

202488

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

202499

KAT6A
Histone acetyltransferase KAT6A

1

2

High-throughput

0.479

High

202518

CP250
Centrosome-associated protein CEP250

1

1

High-throughput

0.479

High

202520

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

202531

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

202537

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.479

High

202545

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.479

High

202557

MAFB
Transcription factor MafB

1

1

High-throughput

0.479

High

159116

CSKP
Peripheral plasma membrane protein CASK

1

0

High-throughput

0.460

High

202451

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.460

High

202478

NAV2
Neuron navigator 2

1

0

High-throughput

0.460

High

122381

MEN1
Menin

1

0

High-throughput

0.458

High

148164

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

202338

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

202341

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

202356

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

202359

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.458

High

202361

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

202368

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

202369

RINI
Ribonuclease inhibitor

1

0

High-throughput

0.458

High

202371

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

202374

NUCL
Nucleolin

1

0

High-throughput

0.458

High

202375

TBG1
Tubulin gamma-1 chain

1

0

High-throughput

0.458

High

202376

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

202379

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

202382

H2B1B
Histone H2B type 1-B

1

0

High-throughput

0.458

High

202385

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

202386

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

202392

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

202394

KC1E
Casein kinase I isoform epsilon

1

0

High-throughput

0.458

High

202396

ZN131
Zinc finger protein 131

1

0

High-throughput

0.458

High

202398

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

202402

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

202411

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

202413

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

202414

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.458

High

202420

RED1
Double-stranded RNA-specific editase 1

1

0

High-throughput

0.458

High

202422

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

202427

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

0

High-throughput

0.458

High

202430

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

202431

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

202434

TRA2A
Transformer-2 protein homolog alpha

1

0

High-throughput

0.458

High

202443

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

202461

CI114
Putative methyltransferase C9orf114

1

0

High-throughput

0.458

High

202470

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

202471

PATL1
Protein PAT1 homolog 1

1

0

High-throughput

0.458

High

202473

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

202474

THOC4
THO complex subunit 4

1

0

High-throughput

0.458

High

202480

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

202487

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

202493

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

202498

PHF3
PHD finger protein 3

1

0

High-throughput

0.458

High

202506

AURKB
Aurora kinase B

1

0

High-throughput

0.458

High

202511

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

202512

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

202514

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

202515

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

202523

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

0

High-throughput

0.458

High

202528

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.458

High

202529

RC3H2
Roquin-2

1

0

High-throughput

0.458

High

202533

ANLN
Anillin

1

0

High-throughput

0.458

High

202536

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

202540

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

202548

RL26L
Ribosomal protein uL24-like

1

0

High-throughput

0.458

High

202553

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

202558

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

202358

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

202384

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

202466

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

202526

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

202349

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

202353

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

202365

CALM3
Calmodulin-3

1

0

High-throughput

0.426

High

202383

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.426

High

202453

NEDD8
NEDD8

1

0

Small-scale

0.426

High

202458

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

202395

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

202336

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

1

High-throughput

0.407

High

202539

TMOD3
Tropomodulin-3

2

0

High-throughput

0.328

High

202467

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.316

High

202477

CC125
Coiled-coil domain-containing protein 125

2

0

High-throughput

0.316

High

202491

SHKB1
SH3KBP1-binding protein 1

2

0

High-throughput

0.316

High

202519

CAR10
Caspase recruitment domain-containing protein 10

2

0

High-throughput

0.316

High

202549

LZTS1
Leucine zipper putative tumor suppressor 1

2

0

High-throughput

0.316

High

202400

RAB4B
Ras-related protein Rab-4B

1

0

High-throughput

0.279

Low

202492

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.265

Low

202509

CC136
Coiled-coil domain-containing protein 136

1

0

High-throughput

0.251

Low

159692

CASQ2
Calsequestrin-2

1

0

High-throughput

0.249

Low

202355

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

202381

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

202484

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

202507

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

202521

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

202373

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024