Protein: VSIG4
V-set and immunoglobulin domain-containing protein 4 (Protein Z39Ig)

Gene: VSIG4
Organism: Homo sapiens
Interactions: 179
UniProt ID: Q9Y279

Gene Ontology (top 5):
GO:0001851 - complement component C3b binding
GO:0006957 - complement activation, alternative pathway
GO:0016020 - membrane
GO:0032703 - negative regulation of interleukin-2 production
GO:0032991 - protein-containing complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

300373

AGRL1
Adhesion G protein-coupled receptor L1

3

2

High-throughput

0.861

High

518535

ADT3
ADP/ATP translocase 3

3

3

High-throughput

0.861

High

1356874

KDIS
Kinase D-interacting substrate of 220 kDa

3

5

High-throughput

0.861

High

1377077

ORNT1
Mitochondrial ornithine transporter 1

3

4

High-throughput

0.861

High

851390

NEK3
Serine/threonine-protein kinase Nek3

3

4

High-throughput

0.770

High

1160309

PKN3
Serine/threonine-protein kinase N3

3

2

High-throughput

0.770

High

1313428

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

2

3

High-throughput

0.726

High

153191

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

2

1

High-throughput

0.705

High

309921

UCP5
Brain mitochondrial carrier protein 1

2

3

High-throughput

0.705

High

845894

RAB13
Ras-related protein Rab-13

2

4

High-throughput

0.705

High

854919

CTR2
Cationic amino acid transporter 2

2

3

High-throughput

0.705

High

1127507

WDR44
WD repeat-containing protein 44

2

3

High-throughput

0.705

High

1241480

DGLB
Diacylglycerol lipase-beta

2

1

High-throughput

0.705

High

1309207

KLDC3
Kelch domain-containing protein 3

2

2

High-throughput

0.705

High

1335806

PCDH9
Protocadherin-9

2

1

High-throughput

0.705

High

199486

SPIT1
Kunitz-type protease inhibitor 1

1

6

High-throughput

0.691

High

738426

BMR1A
Bone morphogenetic protein receptor type-1A

1

1

High-throughput

0.691

High

792738

EAA1
Excitatory amino acid transporter 1

1

3

High-throughput

0.691

High

792868

EAA3
Excitatory amino acid transporter 3

1

3

High-throughput

0.691

High

884458

RAB38
Ras-related protein Rab-38

1

12

High-throughput

0.691

High

1013991

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

1

High-throughput

0.691

High

1016047

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

2

High-throughput

0.691

High

1329726

SPNS1
Protein spinster homolog 1

1

1

High-throughput

0.691

High

1335556

S38AA
Solute carrier family 38 member 10

1

1

High-throughput

0.691

High

1357796

XCT
Cystine/glutamate transporter

1

3

High-throughput

0.691

High

1377080

S4A7
Sodium bicarbonate cotransporter 3

1

1

High-throughput

0.691

High

344727

CO3
Complement C3

1

1

Small-scale

0.690

High

655512

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

12

High-throughput

0.667

High

212233

ERD23
ER lumen protein-retaining receptor 3

2

0

High-throughput

0.660

High

532885

TF
Tissue factor

1

0

High-throughput

0.656

High

396078

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.647

High

1290336

TV23C
Golgi apparatus membrane protein TVP23 homolog C

3

0

High-throughput

0.638

High

160965

RAB7L
Ras-related protein Rab-7L1

1

14

High-throughput

0.618

High

183397

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

1

High-throughput

0.618

High

252886

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

2

High-throughput

0.618

High

646082

AVR2A
Activin receptor type-2A

1

1

High-throughput

0.618

High

993915

PCDH1
Protocadherin-1

1

1

High-throughput

0.618

High

994692

DDR1
Epithelial discoidin domain-containing receptor 1

1

16

High-throughput

0.618

High

1085225

PRSS8
Prostasin

1

5

High-throughput

0.618

High

1100222

MICB
MHC class I polypeptide-related sequence B

1

5

High-throughput

0.618

High

1131575

KMCP1
Kidney mitochondrial carrier protein 1

1

3

High-throughput

0.618

High

1166452

SE6L2
Seizure 6-like protein 2

1

1

High-throughput

0.618

High

1185048

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

4

High-throughput

0.618

High

1230072

RPTOR
Regulatory-associated protein of mTOR

1

8

High-throughput

0.618

High

1251253

WDR48
WD repeat-containing protein 48

1

4

High-throughput

0.618

High

1305438

OSMR
Oncostatin-M-specific receptor subunit beta

1

9

High-throughput

0.618

High

1312262

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

18

High-throughput

0.618

High

1318258

KPCD2
Serine/threonine-protein kinase D2

1

2

High-throughput

0.618

High

1332571

ANTR1
Anthrax toxin receptor 1

1

2

High-throughput

0.618

High

1335675

TPC
Mitochondrial thiamine pyrophosphate carrier

1

4

High-throughput

0.618

High

1342289

ABCB6
ATP-binding cassette sub-family B member 6

1

2

High-throughput

0.618

High

1350028

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

14

High-throughput

0.618

High

1377076

TBL2
Transducin beta-like protein 2

1

4

High-throughput

0.618

High

326899

FADS2
Acyl-CoA 6-desaturase

1

1

High-throughput

0.618

High

384036

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

17

High-throughput

0.618

High

1349243

MTCH1
Mitochondrial carrier homolog 1

1

5

High-throughput

0.618

High

958336

AT2C1
Calcium-transporting ATPase type 2C member 1

2

5

High-throughput

0.611

High

1287592

GCP3
Gamma-tubulin complex component 3

2

1

High-throughput

0.611

High

686208

GLPK
Glycerol kinase

3

1

High-throughput

0.609

High

966901

AT2B2
Plasma membrane calcium-transporting ATPase 2

3

3

High-throughput

0.609

High

1267498

AP3S1
AP-3 complex subunit sigma-1

3

1

High-throughput

0.609

High

1293902

INT4
Integrator complex subunit 4

3

1

High-throughput

0.609

High

1332414

ZDHC6
Palmitoyltransferase ZDHHC6

3

1

High-throughput

0.609

High

1346579

INT7
Integrator complex subunit 7

3

1

High-throughput

0.609

High

1349861

SH3B4
SH3 domain-binding protein 4

3

1

High-throughput

0.609

High

1354034

S53A1
Solute carrier family 53 member 1

3

1

High-throughput

0.609

High

154425

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

0

High-throughput

0.578

High

783277

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

High-throughput

0.578

High

1292310

AURKB
Aurora kinase B

1

0

High-throughput

0.578

High

1357172

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.578

High

787699

PI4KA
Phosphatidylinositol 4-kinase alpha

1

4

High-throughput

0.575

High

1072736

UBE3C
Ubiquitin-protein ligase E3C

2

4

High-throughput

0.558

High

1162960

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

2

3

High-throughput

0.558

High

306891

VAMP5
Vesicle-associated membrane protein 5

2

4

High-throughput

0.553

High

1234953

JAGN1
Protein jagunal homolog 1

2

1

High-throughput

0.553

High

131112

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.553

High

729387

VGFR3
Vascular endothelial growth factor receptor 3

1

15

High-throughput

0.553

High

1117815

Q4LE69
1-phosphatidylinositol 4-kinase

1

2

High-throughput

0.553

High

1241975

GLT11
Polypeptide N-acetylgalactosaminyltransferase 11

1

1

High-throughput

0.553

High

1318989

SEM4C
Semaphorin-4C

1

1

High-throughput

0.553

High

1342383

RAB18
Ras-related protein Rab-18

1

5

High-throughput

0.553

High

318542

CDS2
Phosphatidate cytidylyltransferase 2

1

4

High-throughput

0.536

High

619299

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

5

High-throughput

0.536

High

787608

MTOR
Serine/threonine-protein kinase mTOR

1

7

High-throughput

0.536

High

1139470

ECM29
Proteasome adapter and scaffold protein ECM29

1

7

High-throughput

0.536

High

1145418

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

3

High-throughput

0.536

High

1152280

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

3

High-throughput

0.536

High

1191899

FRMD5
FERM domain-containing protein 5

1

6

High-throughput

0.536

High

1199779

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

3

High-throughput

0.536

High

1224987

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

2

High-throughput

0.536

High

1264963

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

1

High-throughput

0.536

High

1266602

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

5

High-throughput

0.536

High

1267928

LGAT1
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

1

2

High-throughput

0.536

High

1293080

MYO19
Unconventional myosin-XIX

1

4

High-throughput

0.536

High

1331930

HEAT1
HEAT repeat-containing protein 1

1

2

High-throughput

0.536

High

1334396

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

1336585

AT131
Endoplasmic reticulum transmembrane helix translocase

1

5

High-throughput

0.536

High

1377078

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

5

High-throughput

0.536

High

224555

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.513

High

528192

CY24A
Cytochrome b-245 light chain

1

0

High-throughput

0.513

High

839359

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

0

High-throughput

0.513

High

1128989

S27A3
Long-chain fatty acid transport protein 3

1

0

High-throughput

0.513

High

1144518

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.513

High

1147573

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

0

High-throughput

0.513

High

1160548

INT5
Integrator complex subunit 5

1

0

High-throughput

0.513

High

1260445

S20A1
Sodium-dependent phosphate transporter 1

1

0

High-throughput

0.513

High

1331876

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.513

High

1346612

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.513

High

1347868

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

0

High-throughput

0.513

High

1356511

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

0

High-throughput

0.513

High

1068151

PDK2
[Pyruvate dehydrogenase

1

1

High-throughput

0.494

High

135722

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

1

High-throughput

0.489

High

168214

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

3

High-throughput

0.489

High

229754

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

3

High-throughput

0.489

High

297208

IPO13
Importin-13

1

12

High-throughput

0.489

High

523217

SRC
Proto-oncogene tyrosine-protein kinase Src

1

10

High-throughput

0.489

High

616890

JAK1
Tyrosine-protein kinase JAK1

1

18

High-throughput

0.489

High

871982

AT12A
Potassium-transporting ATPase alpha chain 2

1

4

High-throughput

0.489

High

883953

SYJ2B
Synaptojanin-2-binding protein

1

9

High-throughput

0.489

High

960676

BORG5
Cdc42 effector protein 1

1

1

High-throughput

0.489

High

1016116

SRBP2
Sterol regulatory element-binding protein 2

1

1

High-throughput

0.489

High

1050498

DOCK1
Dedicator of cytokinesis protein 1

1

10

High-throughput

0.489

High

1057431

SMC1A
Structural maintenance of chromosomes protein 1A

1

2

High-throughput

0.489

High

1121769

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

1

High-throughput

0.489

High

1135367

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

High-throughput

0.489

High

1159583

TTC27
Tetratricopeptide repeat protein 27

1

2

High-throughput

0.489

High

1162142

RHDF2
Inactive rhomboid protein 2

1

2

High-throughput

0.489

High

1185407

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.489

High

1189571

MON2
Protein MON2 homolog

1

4

High-throughput

0.489

High

1264584

ELYS
Protein ELYS

1

3

High-throughput

0.489

High

1301949

MYADM
Myeloid-associated differentiation marker

1

1

High-throughput

0.489

High

1329823

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

2

High-throughput

0.489

High

1332966

DOCK5
Dedicator of cytokinesis protein 5

1

1

High-throughput

0.489

High

1344712

PYRG2
CTP synthase 2

1

1

High-throughput

0.489

High

1346120

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

3

High-throughput

0.489

High

1346561

DJC11
DnaJ homolog subfamily C member 11

1

9

High-throughput

0.489

High

1346938

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.489

High

1377079

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

5

High-throughput

0.489

High

598549

NF1
Neurofibromin

1

5

High-throughput

0.479

High

69500

UPK3L
Uroplakin-3b-like protein 1

1

0

High-throughput

0.458

High

968243

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.458

High

129352

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.437

High

297431

MYO1D
Unconventional myosin-Id

1

3

High-throughput

0.437

High

1267456

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

17

High-throughput

0.437

High

1295748

FACR2
Fatty acyl-CoA reductase 2

1

1

High-throughput

0.437

High

62588

TCAF2
TRPM8 channel-associated factor 2

3

0

High-throughput

0.347

High

315091

SGPL1
Sphingosine-1-phosphate lyase 1

3

0

High-throughput

0.347

High

319477

RPP29
Ribonuclease P protein subunit p29

3

0

High-throughput

0.347

High

371114

NU1M
NADH-ubiquinone oxidoreductase chain 1

3

0

High-throughput

0.347

High

1120131

TIGD5
Tigger transposable element-derived protein 5

3

0

High-throughput

0.347

High

1218661

DEN6A
Protein DENND6A

3

0

High-throughput

0.347

High

1261162

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

3

0

High-throughput

0.347

High

1354495

MTFP1
Mitochondrial fission process protein 1

3

0

High-throughput

0.347

High

942083

RPP38
Ribonuclease P protein subunit p38

2

0

High-throughput

0.318

High

1002107

ABD18
Protein ABHD18

2

0

High-throughput

0.318

High

1281129

FATE1
Fetal and adult testis-expressed transcript protein

2

0

High-throughput

0.316

High

1168494

TRI72
Tripartite motif-containing protein 72

1

0

Small-scale

0.292

High

167300

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.279

Low

176653

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.279

Low

296579

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

0

High-throughput

0.279

Low

975396

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

High-throughput

0.279

Low

1060123

STAR3
StAR-related lipid transfer protein 3

1

0

High-throughput

0.279

Low

1149536

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.279

Low

1156992

NEPRO
Nucleolus and neural progenitor protein

1

0

High-throughput

0.279

Low

1175991

INT8
Integrator complex subunit 8

1

0

High-throughput

0.279

Low

1197806

SCD5
Stearoyl-CoA desaturase 5

1

0

High-throughput

0.279

Low

1242380

MROH1
Maestro heat-like repeat-containing protein family member 1

1

0

High-throughput

0.279

Low

1252019

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.279

Low

1298663

ZN558
Zinc finger protein 558

1

0

High-throughput

0.279

Low

1311107

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.279

Low

1332180

NSUN3
tRNA

1

0

High-throughput

0.279

Low

1345749

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.279

Low

1346913

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

0

High-throughput

0.279

Low

1348846

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

0

High-throughput

0.279

Low

1354703

PISD
Phosphatidylserine decarboxylase proenzyme, mitochondrial

1

0

High-throughput

0.279

Low

1377075

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.279

Low

207128

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.249

Low

1067418

OZF
Zinc finger protein OZF

1

0

High-throughput

0.249

Low

1345024

C42S2
CDC42 small effector protein 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024