Protein: UBP28
Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)

Gene: UBP28, USP28
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q96RU2

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476242

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

9

20

Small-scale

0.977

High

1301511

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

3

14

Small-scale

0.884

High

1301528

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

3

16

High-throughput

0.867

High

347654

MYC
Myc proto-oncogene protein

6

20

Small-scale

0.729

High

1019094

TP53B
TP53-binding protein 1

5

13

Small-scale

0.706

High

307207

KLHL2
Kelch-like protein 2

3

9

Small-scale

0.656

High

777069

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

16

High-throughput

0.647

High

800620

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

14

High-throughput

0.647

High

870877

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

17

High-throughput

0.647

High

1024403

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

20

High-throughput

0.647

High

1174030

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

15

High-throughput

0.647

High

1257019

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

19

High-throughput

0.647

High

1273812

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

17

High-throughput

0.647

High

1301529

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

18

High-throughput

0.647

High

1301531

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

19

High-throughput

0.647

High

1301533

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

20

High-throughput

0.647

High

387345

P53
Cellular tumor antigen p53

3

8

Small-scale

0.641

High

232446

KDM1A
Lysine-specific histone demethylase 1A

2

8

Small-scale

0.634

High

902725

SUMO2
Small ubiquitin-related modifier 2

2

8

Small-scale

0.629

High

1301520

SENP2
Sentrin-specific protease 2

2

5

High-throughput

0.628

High

228433

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

1281331

FBXW7
F-box/WD repeat-containing protein 7

1

10

Small-scale

0.618

High

1253870

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.602

High

776796

STAT3
Signal transducer and activator of transcription 3

2

7

Small-scale

0.584

High

1068495

KPCD1
Serine/threonine-protein kinase D1

1

7

Small-scale

0.561

High

1301525

SENP1
Sentrin-specific protease 1

1

5

Small-scale

0.561

High

529603

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.541

High

865076

TTC3
E3 ubiquitin-protein ligase TTC3

1

9

High-throughput

0.541

High

1301518

UCK1
Uridine-cytidine kinase 1

1

0

Small-scale

0.537

High

63054

MSGN1
Mesogenin-1

1

2

High-throughput

0.536

High

272680

OFD1
Centriole and centriolar satellite protein OFD1

1

16

High-throughput

0.536

High

542910

BRAF
Serine/threonine-protein kinase B-raf

1

8

High-throughput

0.536

High

574417

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

734738

TRI23
E3 ubiquitin-protein ligase TRIM23

1

7

High-throughput

0.536

High

749797

BRCA1
Breast cancer type 1 susceptibility protein

1

20

High-throughput

0.536

High

928438

DYL1
Dynein light chain 1, cytoplasmic

1

3

High-throughput

0.536

High

952857

FOXK1
Forkhead box protein K1

1

8

High-throughput

0.536

High

969060

GCYB1
Guanylate cyclase soluble subunit beta-1

1

3

High-throughput

0.536

High

1068877

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.536

High

1268433

APBP2
Amyloid protein-binding protein 2

1

3

High-throughput

0.536

High

1291279

DYL2
Dynein light chain 2, cytoplasmic

1

3

High-throughput

0.536

High

1158305

CDC73
Parafibromin

1

2

Small-scale

0.527

High

230789

AQR
RNA helicase aquarius

1

3

High-throughput

0.515

High

263954

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.513

High

300955

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.513

High

456628

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

12

High-throughput

0.501

High

548118

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

12

High-throughput

0.501

High

1028421

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

9

Small-scale

0.501

High

1065234

JOS1
Josephin-1

1

3

High-throughput

0.501

High

1085649

HIF1A
Hypoxia-inducible factor 1-alpha

1

8

Small-scale

0.501

High

1264879

RFFL
E3 ubiquitin-protein ligase rififylin

1

14

High-throughput

0.501

High

1267099

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

12

High-throughput

0.501

High

1270608

STAM1
Signal transducing adapter molecule 1

1

4

High-throughput

0.501

High

1282017

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.501

High

1288085

OTUB2
Ubiquitin thioesterase OTUB2

1

3

High-throughput

0.501

High

1291546

OTUB1
Ubiquitin thioesterase OTUB1

1

3

High-throughput

0.501

High

1297116

SENP8
Sentrin-specific protease 8

1

5

High-throughput

0.501

High

1301513

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.501

High

1301516

ATX3L
Ataxin-3-like protein

1

3

High-throughput

0.501

High

1301534

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

12

High-throughput

0.501

High

615462

KALM
Anosmin-1

1

5

High-throughput

0.489

High

1031057

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

2

High-throughput

0.489

High

317754

STABP
STAM-binding protein

1

0

High-throughput

0.480

High

1056807

ESPL1
Separin

1

0

High-throughput

0.480

High

1297857

NSE2
E3 SUMO-protein ligase NSE2

1

0

Small-scale

0.480

High

160727

AURKA
Aurora kinase A

1

14

Small-scale

0.479

High

244819

BRD4
Bromodomain-containing protein 4

1

17

High-throughput

0.479

High

487697

ANDR
Androgen receptor

1

18

High-throughput

0.479

High

507585

PIM1
Serine/threonine-protein kinase pim-1

1

12

Small-scale

0.479

High

555183

CD44
CD44 antigen

1

2

Small-scale

0.479

High

1016096

SRBP2
Sterol regulatory element-binding protein 2

1

11

Small-scale

0.479

High

1031586

ATM
Serine-protein kinase ATM

1

8

Small-scale

0.479

High

1056946

MDC1
Mediator of DNA damage checkpoint protein 1

1

14

Small-scale

0.479

High

1061211

NUMA1
Nuclear mitotic apparatus protein 1

1

18

Small-scale

0.479

High

1188750

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

10

High-throughput

0.479

High

1200596

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1243068

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

1

Small-scale

0.479

High

1255666

RBCC1
RB1-inducible coiled-coil protein 1

1

20

High-throughput

0.479

High

1273554

TF3B
Transcription factor IIIB 90 kDa subunit

1

4

Small-scale

0.479

High

1282116

OSBP2
Oxysterol-binding protein 2

1

1

High-throughput

0.479

High

1299454

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

Small-scale

0.479

High

1301515

P63
Tumor protein 63

1

8

Small-scale

0.479

High

1301517

LN28A
Protein lin-28 homolog A

1

5

Small-scale

0.479

High

1301519

CLSPN
Claspin

1

5

Small-scale

0.479

High

1301521

ZN304
Zinc finger protein 304

1

6

Small-scale

0.479

High

1301522

TF7L2
Transcription factor 7-like 2

1

7

Small-scale

0.479

High

1301523

METL5
rRNA N6-adenosine-methyltransferase METTL5

1

3

Small-scale

0.479

High

1301524

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1301527

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1301530

NUP50
Nuclear pore complex protein Nup50

1

3

High-throughput

0.479

High

815920

MTR1A
Melatonin receptor type 1A

1

4

High-throughput

0.464

High

537572

PA2GA
Phospholipase A2, membrane associated

1

5

Small-scale

0.457

High

1245294

PJA1
E3 ubiquitin-protein ligase Praja-1

1

12

High-throughput

0.457

High

517417

PCNA
Proliferating cell nuclear antigen

1

3

High-throughput

0.457

High

906095

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

5

High-throughput

0.445

High

1190068

MAVS
Mitochondrial antiviral-signaling protein

1

17

Small-scale

0.437

High

1301526

PIM2
Serine/threonine-protein kinase pim-2

1

6

Small-scale

0.437

High

89979

D6R9G5
Kelch like family member 2

1

8

High-throughput

0.407

High

1202536

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

0

High-throughput

0.347

High

551416

SIAT1
Beta-galactoside alpha-2,6-sialyltransferase 1

2

0

High-throughput

0.328

High

1301532

RT07
Small ribosomal subunit protein uS7m

2

0

High-throughput

0.328

High

1197930

TEDC1
Tubulin epsilon and delta complex protein 1

1

0

High-throughput

0.279

Low

1297630

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.279

Low

1301512

PAFA2
Platelet-activating factor acetylhydrolase 2, cytoplasmic

1

0

High-throughput

0.279

Low

1301514

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024