Protein: STING
Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)

Gene: STING, STING1
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q86WV6

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000139 - Golgi membrane
GO:0000421 - autophagosome membrane
GO:0002218 - activation of innate immune response
GO:0002221 - pattern recognition receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1203539

STING
Stimulator of interferon genes protein

14

2

Small-scale

0.983

High

1203589

TBK1
Serine/threonine-protein kinase TBK1

28

7

Small-scale

0.767

High

1190021

MAVS
Mitochondrial antiviral-signaling protein

12

1

Small-scale

0.756

High

1056432

IRF3
Interferon regulatory factor 3

7

2

Small-scale

0.739

High

1050234

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

5

6

Small-scale

0.702

High

1085804

IF16
Gamma-interferon-inducible protein 16

4

0

Small-scale

0.678

High

1024704

TRAF3
TNF receptor-associated factor 3

4

5

Small-scale

0.676

High

1203586

UBP35
Ubiquitin carboxyl-terminal hydrolase 35

3

9

Small-scale

0.670

High

1023294

TRI32
E3 ubiquitin-protein ligase TRIM32

3

6

Small-scale

0.664

High

321914

RIGI
Antiviral innate immune response receptor RIG-I

3

5

Small-scale

0.657

High

1203571

RNF5
E3 ubiquitin-protein ligase RNF5

3

3

Small-scale

0.650

High

1203572

TRI56
E3 ubiquitin-protein ligase TRIM56

3

4

Small-scale

0.640

High

173732

SURF4
Surfeit locus protein 4

2

1

Small-scale

0.634

High

1173814

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

2

6

Small-scale

0.624

High

1203575

RNF26
E3 ubiquitin-protein ligase RNF26

2

4

Small-scale

0.624

High

1203594

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

8

Small-scale

0.624

High

1027507

STX5
Syntaxin-5

2

3

High-throughput

0.606

High

1203564

REEP6
Receptor expression-enhancing protein 6

2

3

High-throughput

0.606

High

1203585

TECR
Very-long-chain enoyl-CoA reductase

2

1

High-throughput

0.606

High

890236

SC61B
Protein transport protein Sec61 subunit beta

2

1

Small-scale

0.594

High

315021

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

High-throughput

0.586

High

763034

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.586

High

809927

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

3

High-throughput

0.586

High

1203560

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.586

High

1203567

MBOA7
Lysophospholipid acyltransferase 7

1

2

High-throughput

0.586

High

390335

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

1

High-throughput

0.584

High

70821

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.580

High

307707

LERL1
Leptin receptor overlapping transcript-like 1

2

0

High-throughput

0.580

High

1203583

TM100
Transmembrane protein 100

2

0

High-throughput

0.580

High

1138813

MYSM1
Deubiquitinase MYSM1

1

1

Small-scale

0.578

High

1203588

TRI10
Tripartite motif-containing protein 10

1

2

Small-scale

0.578

High

296937

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.561

High

848414

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.561

High

1203541

CCD50
Coiled-coil domain-containing protein 50

1

1

Small-scale

0.561

High

1203559

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

5

Small-scale

0.561

High

1203597

RN115
E3 ubiquitin-protein ligase RNF115

1

2

Small-scale

0.561

High

786491

STAT6
Signal transducer and activator of transcription 6

1

4

Small-scale

0.554

High

1203574

YIPF2
Protein YIPF2

2

2

High-throughput

0.553

High

62954

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

1

High-throughput

0.536

High

167961

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.536

High

316670

ACSL3
Fatty acid CoA ligase Acsl3

1

2

High-throughput

0.536

High

456236

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

1

Small-scale

0.536

High

456287

IFIT1
Interferon-induced protein with tetratricopeptide repeats 1

1

1

Small-scale

0.536

High

609678

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

2

High-throughput

0.536

High

706719

MRP1
Multidrug resistance-associated protein 1

1

3

High-throughput

0.536

High

829293

SYHM
Histidine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

901496

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

High-throughput

0.536

High

1065480

S39AE
Metal cation symporter ZIP14

1

2

High-throughput

0.536

High

1203545

CNNM3
Metal transporter CNNM3

1

1

High-throughput

0.536

High

1203547

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

3

High-throughput

0.536

High

1203549

HM13
Minor histocompatibility antigen H13

1

2

High-throughput

0.536

High

1203566

CLP1L
Lipid scramblase CLPTM1L

1

1

High-throughput

0.536

High

795370

SSRB
Translocon-associated protein subunit beta

1

1

Small-scale

0.526

High

1203568

NECT4
Nectin-4

1

2

High-throughput

0.515

High

294207

DDAH1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

1

0

High-throughput

0.513

High

714616

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.513

High

1109558

TKFC
Triokinase/FMN cyclase

1

0

High-throughput

0.513

High

1119202

MBRL
Membralin

1

0

High-throughput

0.513

High

1203556

GLMN
Glomulin

1

0

High-throughput

0.513

High

1203558

YIPF5
Protein YIPF5

1

0

High-throughput

0.513

High

1132660

FKB15
FK506-binding protein 15

1

1

High-throughput

0.489

High

1203546

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

1

1

High-throughput

0.489

High

158503

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

7

Small-scale

0.479

High

271135

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

5

Small-scale

0.479

High

297072

TOM70
Mitochondrial import receptor subunit TOM70

1

3

Small-scale

0.479

High

639607

TNR5
Tumor necrosis factor receptor superfamily member 5

1

2

Small-scale

0.479

High

863475

COPA
Coatomer subunit alpha

1

1

Small-scale

0.479

High

1020776

TRAF2
TNF receptor-associated factor 2

1

4

Small-scale

0.479

High

1087234

H2B2E
Histone H2B type 2-E

1

4

Small-scale

0.479

High

1119442

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

Small-scale

0.479

High

1174163

UBP50
Ubiquitin carboxyl-terminal hydrolase 50

1

4

Small-scale

0.479

High

1203543

CGAS
Cyclic GMP-AMP synthase

1

2

Small-scale

0.479

High

1203544

DHB11
Estradiol 17-beta-dehydrogenase 11

1

6

High-throughput

0.479

High

1203548

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

1

Small-scale

0.479

High

1203551

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1203553

LMO7
LIM domain only protein 7

1

3

Small-scale

0.479

High

1203555

IRF7
Interferon regulatory factor 7

1

2

Small-scale

0.479

High

1203557

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

8

Small-scale

0.479

High

1203561

FAF2
FAS-associated factor 2

1

3

Small-scale

0.479

High

1203569

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

4

Small-scale

0.479

High

1203570

ELF4
ETS-related transcription factor Elf-4

1

1

Small-scale

0.479

High

1203573

DERL1
Derlin-1

1

1

High-throughput

0.479

High

1203578

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.479

High

1203580

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1203590

SEPT9
Septin-9

1

2

Small-scale

0.479

High

1203592

UBP18
Ubl carboxyl-terminal hydrolase 18

1

8

Small-scale

0.479

High

1203593

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

2

Small-scale

0.479

High

1203596

TRAF6
TNF receptor-associated factor 6

1

5

Small-scale

0.479

High

1203599

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

4

Small-scale

0.479

High

209340

TSN6
Tetraspanin-6

1

1

Small-scale

0.470

High

170679

AXIN1
Axin-1

1

0

Small-scale

0.458

High

200124

DAPK3
Death-associated protein kinase 3

1

0

Small-scale

0.458

High

241894

PQBP1
Polyglutamine-binding protein 1

1

0

Small-scale

0.458

High

387033

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

475086

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

1203563

OTUD5
OTU domain-containing protein 5

1

0

Small-scale

0.458

High

1203579

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

563309

ZNF16
Zinc finger protein 16

1

1

Small-scale

0.457

High

168189

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

6

Small-scale

0.445

High

238237

MOT2
Monocarboxylate transporter 2

1

6

Small-scale

0.445

High

518889

TPR
Nucleoprotein TPR

1

2

Small-scale

0.445

High

573777

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

5

Small-scale

0.445

High

641244

DNMT1
DNA

1

1

Small-scale

0.445

High

776732

STAT3
Signal transducer and activator of transcription 3

1

4

Small-scale

0.445

High

795183

SSRA
Translocon-associated protein subunit alpha

1

1

Small-scale

0.445

High

834428

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

Small-scale

0.445

High

928974

SKP1
S-phase kinase-associated protein 1

1

1

Small-scale

0.445

High

997408

VAC14
Protein VAC14 homolog

1

3

Small-scale

0.445

High

1118314

GRAP1
GRIP1-associated protein 1

1

3

Small-scale

0.445

High

1173956

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

2

Small-scale

0.445

High

1203540

RBM45
RNA-binding protein 45

1

2

Small-scale

0.445

High

1203550

DDX54
ATP-dependent RNA helicase DDX54

1

3

Small-scale

0.445

High

1203576

KPCD2
Serine/threonine-protein kinase D2

1

2

Small-scale

0.445

High

1203581

EXOS5
Exosome complex component RRP46

1

2

Small-scale

0.445

High

1203591

MYO6
Unconventional myosin-VI

1

2

Small-scale

0.445

High

1203598

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

1

Small-scale

0.445

High

1203582

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

64538

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

Small-scale

0.426

High

353010

IL1B
Interleukin-1 beta

1

0

Small-scale

0.426

High

378836

HRG
Histidine-rich glycoprotein

1

0

Small-scale

0.426

High

1203542

INT1
Integrator complex subunit 1

1

0

Small-scale

0.426

High

1203554

PRCC
Proline-rich protein PRCC

1

0

Small-scale

0.426

High

1203565

INT4
Integrator complex subunit 4

1

0

Small-scale

0.426

High

1203577

INT2
Integrator complex subunit 2

1

0

Small-scale

0.426

High

1203584

INT7
Integrator complex subunit 7

1

0

Small-scale

0.426

High

1203587

SAE1
SUMO-activating enzyme subunit 1

1

0

Small-scale

0.426

High

1203562

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

2

0

High-throughput

0.316

High

1203595

PLLP
Plasmolipin

2

0

High-throughput

0.316

High

1086643

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.279

Low

1170428

UBR3
E3 ubiquitin-protein ligase UBR3

1

0

High-throughput

0.279

Low

304443

REC8
Meiotic recombination protein REC8 homolog

1

0

Small-scale

0.249

Low

1203552

MITD1
MIT domain-containing protein 1

1

0

Small-scale

0.232

Low

1203600

Z780B
Zinc finger protein 780B

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024