Protein: DRD2
D(2) dopamine receptor (Dopamine D2 receptor)

Gene: DRD2
Organism: Homo sapiens
Interactions: 102
UniProt ID: P14416

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001591 - dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001659 - temperature homeostasis
GO:0001666 - response to hypoxia
GO:0001669 - acrosomal vesicle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

572406

DRD2
D(2) dopamine receptor

2

16

Small-scale

0.768

High

572416

ARRB2
Beta-arrestin-2

2

8

Small-scale

0.754

High

572415

SSR2
Somatostatin receptor type 2

1

19

Small-scale

0.747

High

572413

AA2AR
Adenosine receptor A2a

1

19

Small-scale

0.724

High

572418

OPRM
Mu-type opioid receptor

1

20

Small-scale

0.724

High

186878

GPR37
Prosaposin receptor GPR37

1

19

High-throughput

0.698

High

572417

GASR
Gastrin/cholecystokinin type B receptor

1

18

High-throughput

0.698

High

572457

LPAR1
Lysophosphatidic acid receptor 1

1

20

High-throughput

0.698

High

572432

NCS1
Neuronal calcium sensor 1

3

1

Small-scale

0.665

High

572489

HRH3
Histamine H3 receptor

1

16

Small-scale

0.647

High

572445

COL12
Collectin-12

2

1

High-throughput

0.628

High

436598

KPCB
Protein kinase C beta type

1

3

Small-scale

0.618

High

572409

DRD4
D(4) dopamine receptor

1

17

Small-scale

0.618

High

572410

ARBK1
Beta-adrenergic receptor kinase 1

1

9

Small-scale

0.618

High

572428

ARRB1
Beta-arrestin-1

1

8

Small-scale

0.618

High

572465

NEB2
Neurabin-2

2

20

Small-scale

0.606

High

572408

FLNA
Filamin-A

2

6

Small-scale

0.584

High

572427

TRPC1
Short transient receptor potential channel 1

1

4

Small-scale

0.573

High

572477

DISC1
Disrupted in schizophrenia 1 protein

1

1

Small-scale

0.561

High

155230

AGRB1
Adhesion G protein-coupled receptor B1

1

8

High-throughput

0.541

High

226394

SNG2
Synaptogyrin-2

1

2

High-throughput

0.541

High

252653

TSN3
Tetraspanin-3

1

11

High-throughput

0.541

High

296850

GABR2
Gamma-aminobutyric acid type B receptor subunit 2

1

3

High-throughput

0.541

High

301325

WFS1
Wolframin

1

2

High-throughput

0.541

High

328853

RTN3
Reticulon-3

1

6

High-throughput

0.541

High

572411

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

2

High-throughput

0.541

High

572414

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

3

High-throughput

0.541

High

572419

ARL1
ADP-ribosylation factor-like protein 1

1

5

High-throughput

0.541

High

572421

TSN7
Tetraspanin-7

1

11

High-throughput

0.541

High

572426

B3A3
Anion exchange protein 3

1

1

High-throughput

0.541

High

572431

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.541

High

572433

S35B1
Solute carrier family 35 member B1

1

2

High-throughput

0.541

High

572440

SERC3
Serine incorporator 3

1

1

High-throughput

0.541

High

572443

RTN1
Reticulon-1

1

6

High-throughput

0.541

High

572446

WLS
Protein wntless homolog

1

2

High-throughput

0.541

High

572447

RHBD2
Rhomboid domain-containing protein 2

1

5

High-throughput

0.541

High

572450

LFG1
Protein lifeguard 1

1

3

High-throughput

0.541

High

572452

S15A4
Solute carrier family 15 member 4

1

1

High-throughput

0.541

High

572460

CREL1
Protein disulfide isomerase CRELD1

1

4

High-throughput

0.541

High

572469

ABCA2
ATP-binding cassette sub-family A member 2

1

1

High-throughput

0.541

High

572470

YIPF3
Protein YIPF3

1

3

High-throughput

0.541

High

572471

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.541

High

572474

GDPD2
Glycerophosphoinositol inositolphosphodiesterase GDPD2

1

2

High-throughput

0.541

High

572476

RTN4
Reticulon-4

1

6

High-throughput

0.541

High

572480

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

3

High-throughput

0.541

High

572482

TEFF2
Tomoregulin-2

1

3

High-throughput

0.541

High

572488

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

1

High-throughput

0.541

High

572490

AGRG1
Adhesion G-protein coupled receptor G1

1

5

High-throughput

0.541

High

329820

SNX4
Sorting nexin-4

1

4

High-throughput

0.536

High

572487

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

1

2

High-throughput

0.536

High

451323

NFM
Neurofilament medium polypeptide

1

2

Small-scale

0.527

High

572462

PAWR
PRKC apoptosis WT1 regulator protein

1

2

Small-scale

0.527

High

572473

E41L1
Band 4.1-like protein 1

1

4

Small-scale

0.527

High

572456

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

2

Small-scale

0.523

High

320425

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.518

High

390855

TRFE
Serotransferrin

1

0

High-throughput

0.518

High

572407

TMM11
Transmembrane protein 11, mitochondrial

1

0

High-throughput

0.518

High

572448

PLPR3
Phospholipid phosphatase-related protein type 3

1

0

High-throughput

0.518

High

572449

PAQR6
Membrane progestin receptor delta

1

0

High-throughput

0.518

High

572454

CHPT1
Cholinephosphotransferase 1

1

0

High-throughput

0.518

High

572455

S22AH
Solute carrier family 22 member 17

1

0

High-throughput

0.518

High

572458

APH1A
Gamma-secretase subunit APH-1A

1

0

High-throughput

0.518

High

572463

G137A
Integral membrane protein GPR137

1

0

High-throughput

0.518

High

572475

ZDHC4
Palmitoyltransferase ZDHHC4

1

0

High-throughput

0.518

High

572486

PLLP
Plasmolipin

1

0

High-throughput

0.518

High

572422

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

2

High-throughput

0.515

High

572436

SC6A3
Sodium-dependent dopamine transporter

1

3

Small-scale

0.515

High

572467

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.513

High

572451

KBTB6
Kelch repeat and BTB domain-containing protein 6

1

2

Small-scale

0.512

High

572479

TRPC4
Short transient receptor potential channel 4

1

4

Small-scale

0.501

High

572484

TRPC5
Short transient receptor potential channel 5

1

4

Small-scale

0.501

High

572412

CERS1
Ceramide synthase 1

1

9

High-throughput

0.494

High

572429

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

1

High-throughput

0.494

High

572441

TRAM1
Translocating chain-associated membrane protein 1

1

9

High-throughput

0.494

High

572459

CERS2
Ceramide synthase 2

1

9

High-throughput

0.494

High

572466

SMIM7
Small integral membrane protein 7

1

1

High-throughput

0.494

High

572472

GHITM
Growth hormone-inducible transmembrane protein

1

3

High-throughput

0.494

High

572481

BAP29
B-cell receptor-associated protein 29

1

1

High-throughput

0.494

High

572468

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.489

High

572485

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

3

High-throughput

0.489

High

163609

GNB5
Guanine nucleotide-binding protein subunit beta-5

1

7

Small-scale

0.481

High

572464

CLIC6
Chloride intracellular channel protein 6

1

2

Small-scale

0.481

High

362691

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.479

High

572420

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

Small-scale

0.479

High

572423

KCNJ6
G protein-activated inward rectifier potassium channel 2

1

8

Small-scale

0.479

High

572424

KCNJ5
G protein-activated inward rectifier potassium channel 4

1

8

Small-scale

0.479

High

572425

KCNJ3
G protein-activated inward rectifier potassium channel 1

1

8

Small-scale

0.479

High

572430

DYN2
Dynamin-2

1

3

Small-scale

0.479

High

572434

CLH1
Clathrin heavy chain 1

1

2

Small-scale

0.479

High

572435

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.479

High

572437

CAV1
Caveolin-1

1

6

Small-scale

0.479

High

572438

DYN1
Dynamin-1

1

3

Small-scale

0.479

High

572442

NF2L2
Nuclear factor erythroid 2-related factor 2

1

1

Small-scale

0.479

High

572439

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.437

High

572483

MSRA
Mitochondrial peptide methionine sulfoxide reductase

2

0

High-throughput

0.328

High

522236

OSTP
Osteopontin

1

0

High-throughput

0.282

High

572444

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

0

High-throughput

0.282

High

572453

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

0

High-throughput

0.282

High

572461

TM101
Transmembrane protein 101

1

0

High-throughput

0.282

High

572478

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.282

High

177167

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025