Protein: CRYAB
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)

Gene: CRYAB
Organism: Homo sapiens
Interactions: 177
UniProt ID: P02511

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0001666 - response to hypoxia
GO:0002088 - lens development in camera-type eye
GO:0005198 - structural molecule activity
GO:0005212 - structural constituent of eye lens

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

358943

CRYAB
Alpha-crystallin B chain

26

16

Small-scale

0.993

High

358697

CRYAA
Alpha-crystallin A chain

19

15

Small-scale

0.991

High

358950

HSPB1
Heat shock protein beta-1

12

16

Small-scale

0.984

High

359021

HSPB2
Heat shock protein beta-2

5

16

Small-scale

0.929

High

358951

A4
Amyloid-beta precursor protein

7

2

Small-scale

0.745

High

359087

HSPB8
Heat shock protein beta-8

1

16

Small-scale

0.713

High

324155

BAG3
BAG family molecular chaperone regulator 3

4

9

Small-scale

0.703

High

358979

SYUA
Alpha-synuclein

4

4

Small-scale

0.696

High

358978

CTNB1
Catenin beta-1

4

4

Small-scale

0.691

High

358956

CRGD
Gamma-crystallin D

4

13

Small-scale

0.685

High

358985

CRBB2
Beta-crystallin B2

3

13

Small-scale

0.678

High

358996

GEMI4
Gem-associated protein 4

3

1

High-throughput

0.667

High

359022

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

3

1

High-throughput

0.667

High

359031

C2D1A
Coiled-coil and C2 domain-containing protein 1A

3

4

High-throughput

0.667

High

359066

RBM24
RNA-binding protein 24

3

2

High-throughput

0.667

High

359081

NYNRI
Protein NYNRIN

3

1

High-throughput

0.667

High

359086

CDC23
Cell division cycle protein 23 homolog

3

3

High-throughput

0.667

High

359090

PRLD1
PRELI domain-containing protein 1, mitochondrial

3

1

High-throughput

0.667

High

358982

CASP3
Caspase-3

3

10

Small-scale

0.664

High

262669

CISY
Citrate synthase, mitochondrial

3

2

Small-scale

0.655

High

147843

HSPB6
Heat shock protein beta-6

1

15

Small-scale

0.647

High

358955

CRGC
Gamma-crystallin C

2

13

Small-scale

0.643

High

359048

SMCR8
Guanine nucleotide exchange protein SMCR8

3

0

High-throughput

0.638

High

359063

TIRR
Tudor-interacting repair regulator protein

3

0

High-throughput

0.638

High

358953

CRBA1
Beta-crystallin A3 [Cleaved into: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form]

2

13

Small-scale

0.634

High

358948

MAS
Proto-oncogene Mas

2

4

High-throughput

0.628

High

359053

TFG
Protein TFG

2

2

High-throughput

0.628

High

359057

GMCL1
Germ cell-less protein-like 1

2

3

High-throughput

0.628

High

359084

DDX20
Probable ATP-dependent RNA helicase DDX20

2

7

Small-scale

0.620

High

358972

CCND1
G1/S-specific cyclin-D1

2

4

Small-scale

0.619

High

358959

TPC2B
Trafficking protein particle complex subunit 2B

3

0

High-throughput

0.613

High

358986

MAP1B
Microtubule-associated protein 1B

2

7

High-throughput

0.611

High

359020

CC85B
Coiled-coil domain-containing protein 85B

2

3

High-throughput

0.611

High

359056

SEH1
Nucleoporin SEH1

2

8

High-throughput

0.611

High

359060

LENG8
Leukocyte receptor cluster member 8

2

5

High-throughput

0.611

High

359028

LBH
Protein LBH

2

0

Small-scale

0.609

High

63720

CC85C
Coiled-coil domain-containing protein 85C

3

3

High-throughput

0.609

High

358980

MDHM
Malate dehydrogenase, mitochondrial

2

2

Small-scale

0.602

High

359040

GPBP1
Vasculin

2

0

High-throughput

0.602

High

359088

OAZ3
Ornithine decarboxylase antizyme 3

2

0

High-throughput

0.602

High

359093

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.602

High

301062

FBX21
F-box only protein 21

2

0

High-throughput

0.585

High

358949

P53
Cellular tumor antigen p53

2

5

Small-scale

0.584

High

358991

CASP7
Caspase-7

2

10

Small-scale

0.584

High

359024

KRA61
Keratin-associated protein 6-1

2

0

High-throughput

0.580

High

351566

NEU2
Vasopressin-neurophysin 2-copeptin

2

0

Small-scale

0.577

High

358984

GDF5
Growth/differentiation factor 5

2

1

High-throughput

0.574

High

358968

VEGFA
Vascular endothelial growth factor A, long form

2

1

Small-scale

0.563

High

359004

BAX
Apoptosis regulator BAX

1

6

Small-scale

0.561

High

359005

B2CL1
Bcl-2-like protein 1

1

6

Small-scale

0.561

High

358971

CRYGS
Gamma-crystallin S

1

13

Small-scale

0.554

High

359074

GORS2
Golgi reassembly-stacking protein 2

2

2

High-throughput

0.553

High

358973

PSA3
Proteasome subunit alpha type-3

1

4

Small-scale

0.552

High

359017

SCN5A
Sodium channel protein type 5 subunit alpha

1

0

Small-scale

0.549

High

358970

CAN3
Calpain-3

1

2

High-throughput

0.541

High

358995

RBM11
Splicing regulator RBM11

1

2

High-throughput

0.541

High

359008

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

High-throughput

0.541

High

127088

FOXN3
Forkhead box protein N3

1

3

High-throughput

0.536

High

281974

ANXA9
Annexin A9

1

4

High-throughput

0.536

High

325581

LATS1
Serine/threonine-protein kinase LATS1

1

8

High-throughput

0.536

High

345274

FOS
Protein c-Fos

1

1

High-throughput

0.536

High

358964

ADT3
ADP/ATP translocase 3

1

9

High-throughput

0.536

High

358976

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

359006

FSTL1
Follistatin-related protein 1

1

1

High-throughput

0.536

High

359007

FOXD4
Forkhead box protein D4

1

3

High-throughput

0.536

High

359037

TSN33
Tetraspanin-33

1

1

High-throughput

0.536

High

359042

TEX14
Inactive serine/threonine-protein kinase TEX14

1

11

High-throughput

0.536

High

359067

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

11

High-throughput

0.536

High

359072

S2532
Solute carrier family 25 member 32

1

11

High-throughput

0.536

High

359078

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.536

High

359085

PHF11
PHD finger protein 11

1

2

High-throughput

0.536

High

359065

TM109
Voltage-gated monoatomic cation channel TMEM109

1

0

Small-scale

0.529

High

358958

ANXA4
Annexin A4

1

3

High-throughput

0.515

High

358997

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.515

High

359015

DPYL1
Dihydropyrimidinase-related protein 1

1

1

High-throughput

0.515

High

359049

PRUN2
Protein prune homolog 2

1

1

High-throughput

0.515

High

359058

HSFY1
Heat shock transcription factor, Y-linked

1

2

High-throughput

0.515

High

183002

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.513

High

358947

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.513

High

358952

7B2
Neuroendocrine protein 7B2

1

0

High-throughput

0.513

High

358994

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

359003

AMPD2
AMP deaminase 2

1

0

High-throughput

0.513

High

359036

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.513

High

359039

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.513

High

359047

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.513

High

359054

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.513

High

359064

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.513

High

359068

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

359082

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.513

High

359092

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

358965

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

1

4

Small-scale

0.512

High

358966

CADH1
Cadherin-1

1

0

Small-scale

0.512

High

340971

LALBA
Alpha-lactalbumin

1

1

Small-scale

0.501

High

358967

GFAP
Glial fibrillary acidic protein

1

9

Small-scale

0.501

High

358969

DESM
Desmin

1

9

Small-scale

0.501

High

358975

MIP
Lens fiber major intrinsic protein

1

1

Small-scale

0.501

High

358989

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

1

Small-scale

0.501

High

358999

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

1

Small-scale

0.501

High

359000

HBA
Hemoglobin subunit alpha

1

2

Small-scale

0.501

High

130008

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.493

High

359027

FNDC1
Fibronectin type III domain-containing protein 1

1

5

High-throughput

0.489

High

359045

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

1

High-throughput

0.489

High

359050

ZDH19
Palmitoyltransferase ZDHHC19

1

2

High-throughput

0.489

High

117331

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.481

High

155509

TNPO2
Transportin-2

1

2

High-throughput

0.481

High

276576

TPC6A
Trafficking protein particle complex subunit 6A

1

2

High-throughput

0.481

High

359025

KR195
Keratin-associated protein 19-5

1

2

High-throughput

0.481

High

359041

KRA81
Keratin-associated protein 8-1

1

3

High-throughput

0.481

High

359094

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.481

High

336289

SODC
Superoxide dismutase [Cu-Zn]

1

0

Small-scale

0.480

High

226211

PRKN
E3 ubiquitin-protein ligase parkin

1

5

Small-scale

0.479

High

358954

NFL
Neurofilament light polypeptide

1

9

High-throughput

0.479

High

358960

BCL2
Apoptosis regulator Bcl-2

1

6

Small-scale

0.479

High

358961

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

358977

HSP74
Heat shock 70 kDa protein 4

1

5

Small-scale

0.479

High

358983

CASP2
Caspase-2

1

11

Small-scale

0.479

High

358987

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

358992

CASP9
Caspase-9

1

10

Small-scale

0.479

High

358993

CASP6
Caspase-6

1

10

Small-scale

0.479

High

359002

XIAP
E3 ubiquitin-protein ligase XIAP

1

3

Small-scale

0.479

High

359009

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

359013

HDAC1
Histone deacetylase 1

1

2

Small-scale

0.479

High

359018

MDC1
Mediator of DNA damage checkpoint protein 1

1

4

High-throughput

0.479

High

359019

CASP8
Caspase-8

1

10

Small-scale

0.479

High

359026

Q4LE69
1-phosphatidylinositol 4-kinase

1

2

High-throughput

0.479

High

359033

CASPC
Inactive caspase-12

1

10

Small-scale

0.479

High

359035

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

359038

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

6

High-throughput

0.479

High

359046

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

359051

ASB5
Ankyrin repeat and SOCS box protein 5

1

6

High-throughput

0.479

High

359052

TITIN
Titin

1

10

Small-scale

0.479

High

359055

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.479

High

359059

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

4

Small-scale

0.479

High

359073

FA83D
Protein FAM83D

1

3

High-throughput

0.479

High

359075

PIDD1
p53-induced death domain-containing protein 1

1

3

Small-scale

0.479

High

359076

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

2

High-throughput

0.479

High

359089

TRI33
E3 ubiquitin-protein ligase TRIM33

1

9

Small-scale

0.479

High

359032

CORO6
Coronin-6

1

1

High-throughput

0.470

High

359034

ATL4
ADAMTS-like protein 4

1

1

High-throughput

0.470

High

359083

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

0

Small-scale

0.460

High

259197

CAD16
Cadherin-16

1

0

Small-scale

0.458

High

358945

ALBU
Albumin

1

0

Small-scale

0.458

High

358962

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

358974

CD40L
CD40 ligand

1

0

Small-scale

0.458

High

358990

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.458

High

359001

CRADD
Death domain-containing protein CRADD

1

0

Small-scale

0.458

High

359011

SMAD4
Mothers against decapentaplegic homolog 4

1

0

Small-scale

0.458

High

359014

BMPR2
Bone morphogenetic protein receptor type-2

1

0

Small-scale

0.458

High

359061

TPPC9
Trafficking protein particle complex subunit 9

1

0

High-throughput

0.458

High

359077

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

359080

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.458

High

358946

ALDOA
Fructose-bisphosphate aldolase A

1

2

High-throughput

0.457

High

359016

DCTN1
Dynactin subunit 1

1

10

High-throughput

0.457

High

359029

Q5BJH1
Prosaposin

1

2

High-throughput

0.457

High

358981

PI4KA
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.445

High

358998

LYSC
Lysozyme C

1

1

Small-scale

0.445

High

359010

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.445

High

100365

APRIO
Alternative prion protein

1

1

Small-scale

0.439

High

358963

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.438

High

359071

TM168
Transmembrane protein 168

1

1

Small-scale

0.437

High

359079

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

4

High-throughput

0.437

High

359091

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

351878

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

Small-scale

0.408

High

359012

SQSTM
Sequestosome-1

1

5

Small-scale

0.408

High

359044

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

2

High-throughput

0.407

High

351484

NGF
Beta-nerve growth factor

1

0

Small-scale

0.391

High

358957

FGF2
Fibroblast growth factor 2

1

0

Small-scale

0.391

High

134718

CCL22
C-C motif chemokine 22

1

0

High-throughput

0.282

High

358988

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

359023

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

359030

TMM31
Transmembrane protein 31

1

0

High-throughput

0.279

Low

359043

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.279

Low

359062

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

359070

RSH6A
Radial spoke head protein 6 homolog A

1

0

High-throughput

0.279

Low

358944

APOC2
Apolipoprotein C-II

1

0

Small-scale

0.261

Low

359069

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024