Protein: LSM8
LSM2-LSM8 complex subunit LSM8

Gene: LSM8
Organism: Saccharomyces cerevisiae S288C
Interactions: 101
UniProt ID: P47093

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005681 - spliceosomal complex
GO:0005688 - U6 snRNP

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

818015

LSM4
LSM complex subunit LSM4

8

20

Small-scale

0.974

High

795887

LSM2
LSM complex subunit LSM2

9

20

Small-scale

0.974

High

865284

LSM6
LSM complex subunit LSM6

8

20

Small-scale

0.970

High

865263

SART3
U4/U6 snRNA-associated-splicing factor PRP24

8

10

Small-scale

0.967

High

865275

LSM3
LSM complex subunit LSM3

6

20

Small-scale

0.945

High

865271

LSM7
LSM complex subunit LSM7

6

20

Small-scale

0.942

High

818465

LSM5
LSM complex subunit LSM5

5

15

Small-scale

0.924

High

751754

PRP8
Pre-mRNA-splicing factor 8

5

9

Small-scale

0.916

High

847804

SMD3
Small nuclear ribonucleoprotein Sm D3

5

20

Small-scale

0.912

High

865280

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

4

9

Small-scale

0.896

High

780192

SN114
Pre-mRNA-splicing factor SNU114

4

15

Small-scale

0.887

High

817122

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

15

High-throughput

0.881

High

678698

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

3

10

High-throughput

0.835

High

865279

SMD1
Small nuclear ribonucleoprotein Sm D1

3

13

High-throughput

0.830

High

865283

SMD2
Small nuclear ribonucleoprotein Sm D2

3

12

High-throughput

0.830

High

865287

SKI7
Superkiller protein 7

2

3

High-throughput

0.778

High

744128

BRR2
Pre-mRNA-splicing helicase BRR2

10

20

Small-scale

0.750

High

625106

PRP9
Pre-mRNA-splicing factor PRP9

2

6

High-throughput

0.737

High

627857

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

5

15

Small-scale

0.715

High

625026

PRP6
Pre-mRNA-splicing factor 6

4

20

Small-scale

0.687

High

865294

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

4

8

Small-scale

0.678

High

645462

XRN1
5'-3' exoribonuclease 1

3

4

High-throughput

0.666

High

864109

LSM1
LSM1-LSM7 complex subunit LSM1

1

17

Small-scale

0.656

High

816659

EDC3
Enhancer of mRNA-decapping protein 3

3

2

High-throughput

0.652

High

865261

MTR3
Exosome complex component MTR3

3

1

High-throughput

0.652

High

865299

HSH49
Protein HSH49

3

9

High-throughput

0.652

High

865262

PRP31
Pre-mRNA-processing factor 31

3

8

Small-scale

0.643

High

654151

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

0

High-throughput

0.622

High

820817

RUXG
Small nuclear ribonucleoprotein G

1

17

High-throughput

0.618

High

865274

RUXF
Small nuclear ribonucleoprotein F

1

20

High-throughput

0.618

High

865289

RU2A
U2 small nuclear ribonucleoprotein A'

1

10

High-throughput

0.618

High

811216

PCF11
Protein PCF11

2

1

High-throughput

0.603

High

865267

DCP2
m7GpppN-mRNA hydrolase

2

2

High-throughput

0.603

High

803771

PIH1
Protein interacting with Hsp90 1

2

0

High-throughput

0.577

High

803790

NEL1
GTPase-activating protein NEL1

2

0

High-throughput

0.577

High

808804

LYS9
Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]

2

0

High-throughput

0.577

High

865265

TOS8
Homeobox protein TOS8

2

0

High-throughput

0.577

High

865268

NOG2
Nucleolar GTP-binding protein 2

2

0

High-throughput

0.577

High

865285

DIB1
Spliceosomal protein DIB1

2

7

High-throughput

0.571

High

865293

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

2

3

High-throughput

0.571

High

545413

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.552

High

678977

NOT1
General negative regulator of transcription subunit 1

1

1

High-throughput

0.541

High

738324

RPN12
26S proteasome regulatory subunit RPN12

1

1

High-throughput

0.536

High

865290

RRP42
Exosome complex component RRP42

1

7

High-throughput

0.536

High

597747

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.513

High

700255

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.513

High

865297

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.513

High

599046

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.508

High

792858

ANM1
Protein arginine N-methyltransferase 1

1

7

High-throughput

0.508

High

864718

BBC1
Myosin tail region-interacting protein MTI1

1

4

High-throughput

0.508

High

865270

JJJ1
J protein JJJ1

1

2

High-throughput

0.508

High

865276

SEN1
Helicase SEN1

1

11

High-throughput

0.508

High

865296

DCP1
mRNA-decapping enzyme subunit 1

1

3

High-throughput

0.508

High

836772

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.500

High

865288

RPN8
26S proteasome regulatory subunit RPN8

1

2

High-throughput

0.489

High

471418

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.486

High

633226

KICH
Choline kinase

1

0

High-throughput

0.486

High

781543

ALY1
Arrestin-related trafficking adapter 6

1

0

High-throughput

0.486

High

865269

ATG2
Autophagy-related protein 2

1

0

High-throughput

0.486

High

865282

LIC4
Protein ATC1/LIC4

1

0

High-throughput

0.486

High

865295

DPH6
Diphthine--ammonia ligase

1

0

High-throughput

0.486

High

865278

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

2

High-throughput

0.481

High

579666

HSC82
ATP-dependent molecular chaperone HSC82

1

4

High-throughput

0.479

High

797311

SP381
Pre-mRNA-splicing factor SPP381

1

1

High-throughput

0.479

High

865277

PRP38
Pre-mRNA-splicing factor 38

1

2

High-throughput

0.479

High

865281

CWC21
Pre-mRNA-splicing factor CWC21

1

1

Small-scale

0.479

High

865291

MED1
Mediator of RNA polymerase II transcription subunit 1

1

2

Small-scale

0.479

High

865292

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

Small-scale

0.479

High

503509

RS28B
Small ribosomal subunit protein eS28B

1

1

High-throughput

0.464

High

575733

BPT1
Bile pigment transporter 1

1

1

High-throughput

0.464

High

796252

TCM62
Mitochondrial chaperone TCM62

1

2

High-throughput

0.464

High

811627

YCFI
Metal resistance protein YCF1

1

1

High-throughput

0.464

High

865266

SCW11
Probable family 17 glucosidase SCW11

1

4

High-throughput

0.464

High

585560

BGL2
Glucan 1,3-beta-glucosidase

1

1

High-throughput

0.457

High

403563

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

5

High-throughput

0.445

High

524417

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

527060

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

670884

SIS1
Protein SIS1

1

3

High-throughput

0.445

High

739161

PRP19
Pre-mRNA-processing factor 19

1

14

Small-scale

0.445

High

741887

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.445

High

506396

YK104
Putative uncharacterized protein YKR104W

1

2

High-throughput

0.439

High

865298

RS28A
Small ribosomal subunit protein eS28A

1

1

High-throughput

0.439

High

865272

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

739681

SPT16
FACT complex subunit SPT16

1

2

High-throughput

0.437

High

617882

COQ1
Hexaprenyl pyrophosphate synthase, mitochondrial

2

0

High-throughput

0.314

High

763716

MTH1
Protein MTH1

2

0

High-throughput

0.314

High

824613

VTH1
VPS10 homolog 1

2

0

High-throughput

0.314

High

865273

YNF0
Uncharacterized protein YNL050C

2

0

High-throughput

0.314

High

453289

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.279

Low

865264

YGL7
Uncharacterized protein YGL117W

1

0

High-throughput

0.279

Low

615278

ARGD
Acetylornithine aminotransferase, mitochondrial

1

0

High-throughput

0.265

Low

677865

AAD3
Putative aryl-alcohol dehydrogenase AAD3

1

0

High-throughput

0.265

Low

743436

MSS4
Protein DSS4

1

0

High-throughput

0.265

Low

754539

PEX6
Peroxisomal ATPase PEX6

1

0

High-throughput

0.265

Low

816581

YEC3
Uncharacterized protein YEL023C

1

0

High-throughput

0.265

Low

835078

SYS1
Protein SYS1

1

0

High-throughput

0.265

Low

865286

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.265

Low

405110

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

661657

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.261

Low

673513

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.261

Low

150222

YL269
Putative uncharacterized protein YLR269C

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025