Protein: OTUL
Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby)

Gene: OTUL, OTULIN
Organism: Homo sapiens
Interactions: 163
UniProt ID: Q96BN8

Gene Ontology (top 5):
GO:0002040 - sprouting angiogenesis
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476169

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

13

1

Small-scale

0.981

High

1285690

SNX27
Sorting nexin-27

5

4

Small-scale

0.938

High

151124

DVL2
Segment polarity protein dishevelled homolog DVL-2

3

1

Small-scale

0.850

High

1285688

RNF31
E3 ubiquitin-protein ligase RNF31

19

2

Small-scale

0.765

High

1285686

OTUL
Ubiquitin thioesterase otulin

2

0

Small-scale

0.728

High

1285698

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

6

2

Small-scale

0.721

High

1075439

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

5

Small-scale

0.705

High

1132913

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

4

High-throughput

0.705

High

1285700

SHRPN
Sharpin

5

1

Small-scale

0.702

High

153940

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

5

High-throughput

0.691

High

305014

DUS14
Dual specificity protein phosphatase 14

3

1

High-throughput

0.667

High

1065153

DAZP2
DAZ-associated protein 2

3

0

High-throughput

0.646

High

883936

SYJ2B
Synaptojanin-2-binding protein

1

1

High-throughput

0.618

High

228299

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.618

High

1033904

SNTB2
Beta-2-syntrophin

1

1

Small-scale

0.618

High

1229714

SPART
Spartin

2

1

High-throughput

0.606

High

1079571

NEDD8
NEDD8

1

0

Small-scale

0.586

High

1151624

OTU7B
OTU domain-containing protein 7B

2

0

High-throughput

0.580

High

1260980

SFT2A
Vesicle transport protein SFT2A

2

0

High-throughput

0.580

High

868019

VMAT1
Chromaffin granule amine transporter

2

1

High-throughput

0.574

High

875201

TERA
Transitional endoplasmic reticulum ATPase

2

1

Small-scale

0.563

High

776166

ARL1
ADP-ribosylation factor-like protein 1

2

0

Small-scale

0.559

High

529529

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

644619

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

1

High-throughput

0.536

High

934377

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.536

High

1021937

SEC20
Vesicle transport protein SEC20

1

1

High-throughput

0.536

High

1285692

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.536

High

1050024

SCRIB
Protein scribble homolog

1

0

Small-scale

0.517

High

67918

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

4

High-throughput

0.514

High

126302

ST1C2
Sulfotransferase 1C2

1

0

High-throughput

0.513

High

895702

CXCR4
C-X-C chemokine receptor type 4

1

0

High-throughput

0.513

High

1043155

CUL4A
Cullin-4A

1

0

High-throughput

0.513

High

779880

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

196846

CYB5B
Cytochrome b5 type B

1

3

High-throughput

0.489

High

217105

NKG2F
NKG2-F type II integral membrane protein

1

1

High-throughput

0.489

High

706922

CD80
T-lymphocyte activation antigen CD80

1

4

High-throughput

0.489

High

783706

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

1

High-throughput

0.489

High

985372

VMAT2
Synaptic vesicular amine transporter

1

1

High-throughput

0.489

High

1158513

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.489

High

1197754

DSG4
Desmoglein-4

1

2

High-throughput

0.489

High

330271

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.480

High

358858

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.480

High

243541

DNJA2
DnaJ homolog subfamily A member 2

1

2

Small-scale

0.479

High

438972

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

1

Small-scale

0.479

High

636392

DNJB1
DnaJ homolog subfamily B member 1

1

2

Small-scale

0.479

High

800612

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

2

Small-scale

0.479

High

835483

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.479

High

835929

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

983650

FAK1
Focal adhesion kinase 1

1

1

Small-scale

0.479

High

1023309

TRI32
E3 ubiquitin-protein ligase TRIM32

1

1

Small-scale

0.479

High

1175086

TBA1A
Tubulin alpha-1A chain

1

1

Small-scale

0.479

High

1190819

BRAP
BRCA1-associated protein

1

5

Small-scale

0.479

High

1285693

DUS9
Dual specificity protein phosphatase 9

1

1

High-throughput

0.479

High

1285694

TBA1C
Tubulin alpha-1C chain

1

1

Small-scale

0.479

High

1285695

TMM43
Transmembrane protein 43

1

1

Small-scale

0.479

High

1285697

DUS23
Dual specificity protein phosphatase 23

1

3

High-throughput

0.479

High

1285699

OSBL8
Oxysterol-binding protein-related protein 8

1

6

Small-scale

0.479

High

1285703

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1285711

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

1

Small-scale

0.479

High

1285716

DDX20
Probable ATP-dependent RNA helicase DDX20

1

1

Small-scale

0.479

High

1285721

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

Small-scale

0.479

High

128612

DNM1L
Dynamin-1-like protein

1

0

Small-scale

0.458

High

131486

IMA4
Importin subunit alpha-4

1

0

Small-scale

0.458

High

151866

IRS4
Insulin receptor substrate 4

1

0

Small-scale

0.458

High

153239

ACOT8
Acyl-coenzyme A thioesterase 8

1

0

Small-scale

0.458

High

175787

HMGB3
High mobility group protein B3

1

0

Small-scale

0.458

High

238809

UGDH
UDP-glucose 6-dehydrogenase

1

0

Small-scale

0.458

High

242752

IF2P
Eukaryotic translation initiation factor 5B

1

0

Small-scale

0.458

High

254622

CLAP2
CLIP-associating protein 2

1

0

Small-scale

0.458

High

255183

ATG13
Autophagy-related protein 13

1

0

Small-scale

0.458

High

335497

NB5R3
NADH-cytochrome b5 reductase 3

1

0

Small-scale

0.458

High

381269

TBB4A
Tubulin beta-4A chain

1

0

Small-scale

0.458

High

504542

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

548115

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

0

Small-scale

0.458

High

594604

PSB1
Proteasome subunit beta type-1

1

0

Small-scale

0.458

High

621267

RIR1
Ribonucleoside-diphosphate reductase large subunit

1

0

Small-scale

0.458

High

678656

METK2
S-adenosylmethionine synthase isoform type-2

1

0

Small-scale

0.458

High

734990

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

0

Small-scale

0.458

High

786408

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.458

High

788220

CASP3
Caspase-3

1

0

Small-scale

0.458

High

807798

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

822341

KC1D
Casein kinase I isoform delta

1

0

Small-scale

0.458

High

835097

TSC2
Tuberin

1

0

Small-scale

0.458

High

843504

ANX11
Annexin A11

1

0

Small-scale

0.458

High

847205

GALK1
Galactokinase

1

0

Small-scale

0.458

High

856230

HXK2
Hexokinase-2

1

0

Small-scale

0.458

High

890790

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

914556

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

Small-scale

0.458

High

934607

PA1B2
Platelet-activating factor acetylhydrolase IB subunit alpha2

1

0

Small-scale

0.458

High

965551

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

0

Small-scale

0.458

High

986539

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

Small-scale

0.458

High

1024067

ACACA
Acetyl-CoA carboxylase 1

1

0

Small-scale

0.458

High

1028265

SBP1
Methanethiol oxidase

1

0

High-throughput

0.458

High

1051895

IF4A2
Eukaryotic initiation factor 4A-II

1

0

Small-scale

0.458

High

1056449

IRF3
Interferon regulatory factor 3

1

0

Small-scale

0.458

High

1056719

PUM1
Pumilio homolog 1

1

0

Small-scale

0.458

High

1083130

DPYL2
Dihydropyrimidinase-related protein 2

1

0

Small-scale

0.458

High

1100547

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

Small-scale

0.458

High

1101210

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1158055

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

0

Small-scale

0.458

High

1171148

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1230505

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.458

High

1256661

GEMI5
Gem-associated protein 5

1

0

Small-scale

0.458

High

1285687

RM38
Large ribosomal subunit protein mL38

1

0

Small-scale

0.458

High

1285689

PTCD3
Small ribosomal subunit protein mS39

1

0

Small-scale

0.458

High

1285691

WRIP1
ATPase WRNIP1

1

0

Small-scale

0.458

High

1285701

ZBP1
Z-DNA-binding protein 1

1

0

Small-scale

0.458

High

1285702

CPVL
Probable serine carboxypeptidase CPVL

1

0

Small-scale

0.458

High

1285705

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1285706

CYBP
Calcyclin-binding protein

1

0

Small-scale

0.458

High

1285708

PFD4
Prefoldin subunit 4

1

0

Small-scale

0.458

High

1285713

HDAC6
Histone deacetylase 6

1

0

Small-scale

0.458

High

1285714

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

0

Small-scale

0.458

High

1285715

TES
Testin

1

0

High-throughput

0.458

High

1285720

RT16
Small ribosomal subunit protein bS16m

1

0

Small-scale

0.458

High

123685

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.437

High

170916

PGRC2
Membrane-associated progesterone receptor component 2

1

2

Small-scale

0.437

High

315048

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

Small-scale

0.437

High

561653

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

Small-scale

0.437

High

809954

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

Small-scale

0.437

High

958315

AT2C1
Calcium-transporting ATPase type 2C member 1

1

2

Small-scale

0.437

High

1244035

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

5

Small-scale

0.437

High

1257234

LRC15
Leucine-rich repeat-containing protein 15

1

1

High-throughput

0.437

High

1285717

SPAT2
Spermatogenesis-associated protein 2

1

0

High-throughput

0.391

High

1267371

F168A
Protein FAM168A

3

0

High-throughput

0.352

High

352680

TNFA
Tumor necrosis factor

3

0

Small-scale

0.334

High

527695

LAMP2
Lysosome-associated membrane glycoprotein 2

2

0

High-throughput

0.328

High

1262226

TM239
Transmembrane protein 239

2

0

High-throughput

0.316

High

1266509

SUSD6
Sushi domain-containing protein 6

2

0

High-throughput

0.316

High

263948

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

400098

ICAM1
Intercellular adhesion molecule 1

1

0

High-throughput

0.279

Low

537764

INSRR
Insulin receptor-related protein

1

0

High-throughput

0.279

Low

1039756

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

1285710

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

0

High-throughput

0.279

Low

1285712

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1285718

B3GT5
Beta-1,3-galactosyltransferase 5

1

0

High-throughput

0.279

Low

156544

SCAM3
Secretory carrier-associated membrane protein 3

1

0

Small-scale

0.249

Low

208625

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

Small-scale

0.249

Low

216298

CALU
Calumenin

1

0

Small-scale

0.249

Low

297081

TOM70
Mitochondrial import receptor subunit TOM70

1

0

Small-scale

0.249

Low

553385

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

658111

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

Small-scale

0.249

Low

670631

ERP29
Endoplasmic reticulum resident protein 29

1

0

Small-scale

0.249

Low

721110

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

881419

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

0

Small-scale

0.249

Low

899996

VA0D1
V-type proton ATPase subunit d 1

1

0

Small-scale

0.249

Low

947119

RT25
Small ribosomal subunit protein mS25

1

0

Small-scale

0.249

Low

947276

RT10
Small ribosomal subunit protein uS10m

1

0

Small-scale

0.249

Low

1048883

BOP1
Ribosome biogenesis protein BOP1

1

0

Small-scale

0.249

Low

1086454

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

Small-scale

0.249

Low

1110318

AL1L2
Mitochondrial 10-formyltetrahydrofolate dehydrogenase

1

0

Small-scale

0.249

Low

1114327

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

Small-scale

0.249

Low

1202875

THOC6
THO complex subunit 6 homolog

1

0

Small-scale

0.249

Low

1220570

NELFD
Negative elongation factor C/D

1

0

Small-scale

0.249

Low

1262975

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

Small-scale

0.249

Low

1282777

FAKD4
FAST kinase domain-containing protein 4

1

0

Small-scale

0.249

Low

1285696

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

Small-scale

0.249

Low

1285704

TFB2M
Dimethyladenosine transferase 2, mitochondrial

1

0

Small-scale

0.249

Low

1285707

TM9S3
Transmembrane 9 superfamily member 3

1

0

Small-scale

0.249

Low

1285709

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

1

0

Small-scale

0.249

Low

1285719

SF3B6
Splicing factor 3B subunit 6

1

0

Small-scale

0.249

Low

1285722

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024