Protein: IF4E
Eukaryotic translation initiation factor 4E1 (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)

Gene: IF4E, eIF4E1
Organism: Drosophila melanogaster
Interactions: 55
UniProt ID: P48598

Gene Ontology (top 5):
GO:0000339 - RNA cap binding
GO:0000340 - RNA 7-methylguanosine cap binding
GO:0000932 - P-body
GO:0003743 - translation initiation factor activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

263474

O61380
Eukaryotic translation initiation factor 4G1, isoform A

15

19

Small-scale

0.982

High

874952

4EBP
Eukaryotic translation initiation factor 4E-binding protein

12

15

Small-scale

0.982

High

874941

CUP
Protein cup

10

1

Small-scale

0.978

High

874944

MXT
Eukaryotic translation initiation factor 4E-binding protein Mextli

4

7

Small-scale

0.697

High

654224

DDX6
ATP-dependent RNA helicase me31b

4

8

Small-scale

0.696

High

874935

Q9VCH1
Eukaryotic translation initiation factor 4G2, isoform A

3

18

Small-scale

0.661

High

874945

Q9VSG1
eIF-4F 25 kDa subunit

1

3

Small-scale

0.625

High

874937

Q9VGI4
non-specific serine/threonine protein kinase

2

4

Small-scale

0.624

High

636385

PABP
Polyadenylate-binding protein

2

2

Small-scale

0.611

High

874950

Q9VY20
RING-type E3 ubiquitin transferase

3

1

High-throughput

0.593

High

304509

AUB
Protein aubergine

2

5

Small-scale

0.584

High

874919

DIAP1
Death-associated inhibitor of apoptosis 1

1

3

Small-scale

0.561

High

874942

Q9VP20
RING-type E3 ubiquitin transferase

2

1

High-throughput

0.542

High

847851

SNRPA
U1 small nuclear ribonucleoprotein A

2

2

Small-scale

0.521

High

874918

SMG
Protein Smaug

1

0

Small-scale

0.512

High

874925

RBP9X
Ran-binding proteins 9/10 homolog

1

3

High-throughput

0.508

High

874951

Q9W4M7
Twenty-four, isoform B

1

1

Small-scale

0.489

High

58302

A1ZBJ8
FI19908p1

1

0

High-throughput

0.486

High

874940

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

1

0

High-throughput

0.486

High

620690

SXL
Protein sex-lethal

1

4

Small-scale

0.479

High

874921

DSOR1
Dual specificity mitogen-activated protein kinase kinase dSOR1

1

3

High-throughput

0.479

High

874924

Q32KD4
Protein argonaute-1

1

5

Small-scale

0.479

High

874929

PRKN
E3 ubiquitin-protein ligase parkin

1

3

Small-scale

0.479

High

874931

Q8SYC0
Bruno 1, isoform D

1

5

Small-scale

0.479

High

874936

GLD2A
Poly(A) RNA polymerase gld-2 homolog A

1

2

Small-scale

0.479

High

874938

DDX3
ATP-dependent RNA helicase bel

1

2

Small-scale

0.479

High

874948

AGO2
Protein argonaute-2

1

4

Small-scale

0.479

High

874916

RBP1
RNA-binding protein 1

1

3

High-throughput

0.464

High

705006

EXU
Maternal protein exuperantia

1

0

Small-scale

0.458

High

874934

Q95RE4
LD37574p

1

0

Small-scale

0.458

High

874943

GOLP3
Golgi phosphoprotein 3 homolog sauron

1

0

High-throughput

0.458

High

874917

Q0IGU0
IP21556p

1

4

High-throughput

0.451

High

654837

MA205
205 kDa microtubule-associated protein

1

1

High-throughput

0.445

High

828070

LA
La protein homolog

1

5

High-throughput

0.445

High

874930

Q8INQ3
GEO13292p1

1

1

High-throughput

0.439

High

356313

O97102
Small ubiquitin-related modifier

1

1

Small-scale

0.437

High

478789

BCD
Homeotic protein bicoid

1

6

Small-scale

0.437

High

602156

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

4

Small-scale

0.437

High

874922

U2AF2
Splicing factor U2AF 50 kDa subunit

1

3

Small-scale

0.437

High

874933

U2AF1
Splicing factor U2af 38 kDa subunit

1

1

Small-scale

0.437

High

874946

Q9VSR5
GM03767p

1

0

High-throughput

0.426

High

874926

Q7JUZ1
LD16427p

1

1

High-throughput

0.417

High

874928

NITO
RNA-binding protein spenito

1

3

Small-scale

0.407

High

874954

Q9Y134
RNA helicase

1

3

High-throughput

0.407

High

874939

Q9VI24
LD25151p

2

0

High-throughput

0.310

High

874953

FL2D
Pre-mRNA-splicing regulator female-lethal(2)D

2

0

Small-scale

0.298

High

263455

O61351
La costa

1

0

High-throughput

0.265

Low

874923

OB10
Putative odorant-binding protein A10

1

0

High-throughput

0.265

Low

874927

Q7K5M2
GH05836p

1

0

High-throughput

0.265

Low

874949

Q9VVA4
Glutamate synthase [NADH]

1

0

High-throughput

0.265

Low

874920

EWG
DNA-binding protein Ewg

1

0

High-throughput

0.251

Low

874947

R10AB
Large ribosomal subunit protein uL1

1

0

Small-scale

0.249

Low

426645

HP1
Heterochromatin protein 1

1

0

High-throughput

0.232

Low

874915

SET
Protein SET

1

0

High-throughput

0.232

Low

874932

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025