Protein: COT2
COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2)

Gene: COT2, NR2F2
Organism: Homo sapiens
Interactions: 132
UniProt ID: P24468

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001893 - maternal placenta development
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0001972 - retinoic acid binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

490050

NR2F6
Nuclear receptor subfamily 2 group F member 6

4

19

Small-scale

0.903

High

377100

GCR
Glucocorticoid receptor

1

19

Small-scale

0.740

High

207539

RNF13
E3 ubiquitin-protein ligase RNF13

3

4

High-throughput

0.667

High

599772

5NTD
5'-nucleotidase

3

1

High-throughput

0.667

High

363997

VTDB
Vitamin D-binding protein

2

2

High-throughput

0.628

High

622764

AKT1
RAC-alpha serine/threonine-protein kinase

2

13

High-throughput

0.628

High

622765

AKT2
RAC-beta serine/threonine-protein kinase

2

14

High-throughput

0.628

High

622770

PI2R
Prostacyclin receptor

2

2

High-throughput

0.628

High

622815

GLMP
Glycosylated lysosomal membrane protein

2

1

High-throughput

0.628

High

622841

S39A9
Zinc transporter ZIP9

2

1

High-throughput

0.628

High

622845

SHPK
Sedoheptulokinase

2

2

High-throughput

0.628

High

622850

SALL2
Sal-like protein 2

2

6

High-throughput

0.628

High

622762

COT2
COUP transcription factor 2

1

20

Small-scale

0.621

High

600510

EPHA1
Ephrin type-A receptor 1

1

1

High-throughput

0.618

High

369000

ESR1
Estrogen receptor

1

20

High-throughput

0.618

High

622775

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

20

Small-scale

0.618

High

622818

ESR2
Estrogen receptor beta

1

20

High-throughput

0.618

High

179435

MPPD1
Metallophosphoesterase domain-containing protein 1

3

5

High-throughput

0.609

High

310265

LYPD3
Ly6/PLAUR domain-containing protein 3

3

1

High-throughput

0.609

High

622849

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

3

2

High-throughput

0.609

High

622810

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.602

High

252740

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

3

6

High-throughput

0.599

High

527300

LAMP2
Lysosome-associated membrane glycoprotein 2

2

1

High-throughput

0.574

High

622766

CD70
CD70 antigen

2

2

High-throughput

0.574

High

622768

APJ
Apelin receptor

2

5

High-throughput

0.574

High

622769

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

3

High-throughput

0.574

High

622778

VMAT1
Chromaffin granule amine transporter

2

2

High-throughput

0.574

High

622811

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

2

2

High-throughput

0.574

High

622819

RPGR
X-linked retinitis pigmentosa GTPase regulator

2

4

High-throughput

0.574

High

622843

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

8

High-throughput

0.574

High

622833

BC11A
B-cell lymphoma/leukemia 11A

1

10

Small-scale

0.573

High

178947

FOXP2
Forkhead box protein P2

1

20

Small-scale

0.561

High

622804

FOXP4
Forkhead box protein P4

1

20

Small-scale

0.561

High

622834

FOXP1
Forkhead box protein P1

1

20

Small-scale

0.561

High

246338

SCN2B
Sodium channel subunit beta-2

2

2

High-throughput

0.558

High

622786

SLAF1
Signaling lymphocytic activation molecule

2

3

High-throughput

0.558

High

622796

TRIP4
Activating signal cointegrator 1

1

3

High-throughput

0.541

High

146746

AGRB1
Adhesion G protein-coupled receptor B1

1

2

High-throughput

0.536

High

157007

AIM2
Interferon-inducible protein AIM2

1

3

High-throughput

0.536

High

302370

CSTN1
Calsyntenin-1

1

4

High-throughput

0.536

High

323592

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

325040

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

4

High-throughput

0.536

High

352495

TNFA
Tumor necrosis factor

1

1

High-throughput

0.536

High

362173

GLPA
Glycophorin-A

1

1

High-throughput

0.536

High

455098

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.536

High

622763

V2R
Vasopressin V2 receptor

1

2

High-throughput

0.536

High

622767

CD80
T-lymphocyte activation antigen CD80

1

5

High-throughput

0.536

High

622771

MAGA8
Melanoma-associated antigen 8

1

3

High-throughput

0.536

High

622772

KI67
Proliferation marker protein Ki-67

1

10

High-throughput

0.536

High

622785

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.536

High

622795

TEAD2
Transcriptional enhancer factor TEF-4

1

1

High-throughput

0.536

High

622800

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.536

High

622801

SO4C1
Solute carrier organic anion transporter family member 4C1

1

1

High-throughput

0.536

High

622816

MADD
MAP kinase-activating death domain protein

1

3

High-throughput

0.536

High

622789

SMAD4
Mothers against decapentaplegic homolog 4

1

10

Small-scale

0.534

High

622781

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

622805

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.513

High

622806

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

622832

HYCCI
Hyccin

1

0

High-throughput

0.513

High

622836

HIPK3
Homeodomain-interacting protein kinase 3

1

20

High-throughput

0.508

High

545938

MYOD1
Myoblast determination protein 1

1

7

Small-scale

0.501

High

622790

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.501

High

622828

PHB2
Prohibitin-2

1

9

Small-scale

0.501

High

126569

P2Y10
Putative P2Y purinoceptor 10

1

9

High-throughput

0.489

High

155884

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

4

High-throughput

0.489

High

171934

GP182
G-protein coupled receptor 182

1

8

High-throughput

0.489

High

258899

RTN2
Reticulon-2

1

1

High-throughput

0.489

High

354673

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

2

High-throughput

0.489

High

545071

PVR
Poliovirus receptor

1

6

High-throughput

0.489

High

622774

GLR
Glucagon receptor

1

3

High-throughput

0.489

High

622776

PTH2R
Parathyroid hormone 2 receptor

1

3

High-throughput

0.489

High

622780

CXCR4
C-X-C chemokine receptor type 4

1

6

High-throughput

0.489

High

622784

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.489

High

622787

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

5

High-throughput

0.489

High

622793

FXYD3
FXYD domain-containing ion transport regulator 3

1

1

High-throughput

0.489

High

622797

MICB
MHC class I polypeptide-related sequence B

1

2

High-throughput

0.489

High

622799

VASN
Vasorin

1

1

High-throughput

0.489

High

622802

SV2A
Synaptic vesicle glycoprotein 2A

1

2

High-throughput

0.489

High

622803

B3GN8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

1

1

High-throughput

0.489

High

622807

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.489

High

622824

IMP1L
Mitochondrial inner membrane protease subunit 1

1

3

High-throughput

0.489

High

622827

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.489

High

622829

CML1
Chemerin-like receptor 1

1

6

High-throughput

0.489

High

622835

TMPS5
Transmembrane protease serine 5

1

5

High-throughput

0.489

High

622814

SETD7
Histone-lysine N-methyltransferase SETD7

1

2

High-throughput

0.481

High

622823

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

Small-scale

0.481

High

122499

MEN1
Menin

1

6

High-throughput

0.479

High

155276

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

243943

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

355198

HBE
Hemoglobin subunit epsilon

1

3

Small-scale

0.479

High

620295

GATA2
Endothelial transcription factor GATA-2

1

8

Small-scale

0.479

High

622779

FOXA1
Hepatocyte nuclear factor 3-alpha

1

18

High-throughput

0.479

High

622782

TFAP4
Transcription factor AP-4

1

3

Small-scale

0.479

High

622792

CUL3
Cullin-3

1

9

High-throughput

0.479

High

622813

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

622821

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

622825

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

20

Small-scale

0.479

High

622826

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

622838

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

20

High-throughput

0.479

High

622846

HERC5
E3 ISG15--protein ligase HERC5

1

5

Small-scale

0.479

High

622831

FACD2
Fanconi anemia group D2 protein

1

0

Small-scale

0.458

High

622842

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

622791

SNW1
SNW domain-containing protein 1

1

6

High-throughput

0.445

High

622822

TET5A
Terminal nucleotidyltransferase 5A

1

1

High-throughput

0.439

High

354814

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

3

High-throughput

0.437

High

355017

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

1

High-throughput

0.437

High

622847

HECD1
E3 ubiquitin-protein ligase HECTD1

1

13

High-throughput

0.437

High

622798

Q5TF85
polynucleotide adenylyltransferase

1

1

High-throughput

0.417

High

92666

E9PNY5
Low affinity immunoglobulin gamma Fc region receptor III-A

1

2

High-throughput

0.407

High

622773

S15A1
Solute carrier family 15 member 1

2

0

High-throughput

0.328

High

622808

SPX3
Sugar phosphate exchanger 3

2

0

High-throughput

0.328

High

622839

PACC1
Proton-activated chloride channel

2

0

High-throughput

0.328

High

622844

WNT16
Protein Wnt-16

2

0

High-throughput

0.328

High

622783

UPAR
Urokinase plasminogen activator surface receptor

2

0

High-throughput

0.318

High

622830

TM2D3
TM2 domain-containing protein 3

2

0

High-throughput

0.318

High

622788

BIK
Bcl-2-interacting killer

1

0

High-throughput

0.282

High

68046

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

173266

S22A2
Solute carrier family 22 member 2

1

0

High-throughput

0.279

Low

217080

NKG2F
NKG2-F type II integral membrane protein

1

0

High-throughput

0.279

Low

245217

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

380358

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

High-throughput

0.279

Low

515990

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

High-throughput

0.279

Low

622777

GPC3
Glypican-3

1

0

High-throughput

0.279

Low

622812

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

622817

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

0

High-throughput

0.279

Low

622820

T106A
Transmembrane protein 106A

1

0

High-throughput

0.279

Low

622840

TREM1
Triggering receptor expressed on myeloid cells 1

1

0

High-throughput

0.279

Low

622848

CLC4A
C-type lectin domain family 4 member A

1

0

High-throughput

0.279

Low

622837

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

622794

KI2S5
Killer cell immunoglobulin-like receptor 2DS5

1

0

High-throughput

0.232

Low

622809

TOIP2
Torsin-1A-interacting protein 2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024