HitPredict

Interactor 1: RN138 (Q8WVD3)
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
Gene: RNF138

Interactor 2: PHF8 (Q9UPP1)
Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8)
Gene: PHF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 1060
+	Hs
		1019385 TRI26_HUMAN (4-239): 2.73e-33: 127: 15.64		PHF8_HUMAN (1-1060): 0: 1403: 100.00
+	Hs
		1245587 RING2_HUMAN (2-188): 8.11e-29: 112: 18.72		KDM2B_HUMAN (75-968): 0: 601: 24.09
+	Mm
		1158239 RING2_MOUSE (2-188): 1.78e-28: 112: 18.72		KDM2B_MOUSE (88-968): 0: 585: 24.52
+	Hs
		987996 RING1_HUMAN (2-74): 3.94e-21: 92.7: 27.40		KDM2B_HUMAN (75-968): 0: 601: 24.09
+	Mm
		193408 RING1_MOUSE (2-74): 1.86e-21: 93.9: 27.40		KDM2B_MOUSE (88-968): 0: 585: 24.52
+	Dm
		1361711 RING1_DROME (2-75): 5.14e-21: 92.7: 27.03		JHD1_DROME (87-594): 0: 583: 33.27
+	Hs
		1304155 RING2_HUMAN (2-188): 8.11e-29: 112: 18.72		CXXC1_HUMAN (11-145): 9.34e-28: 122: 25.93