Protein: PGFRB
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)

Gene: PGFRB, PDGFRB
Organism: Homo sapiens
Interactions: 223
UniProt ID: P09619

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0004992 - platelet activating factor receptor activity
GO:0005017 - platelet-derived growth factor receptor activity
GO:0005019 - platelet-derived growth factor beta-receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

452361

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

22

20

Small-scale

0.985

High

452348

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

10

20

Small-scale

0.971

High

350948

PDGFB
Platelet-derived growth factor subunit B

7

20

Small-scale

0.969

High

452399

PTN11
Tyrosine-protein phosphatase non-receptor type 11

9

20

Small-scale

0.962

High

452343

PGFRA
Platelet-derived growth factor receptor alpha

5

19

Small-scale

0.926

High

452350

RASA1
Ras GTPase-activating protein 1

6

20

Small-scale

0.921

High

452338

SRC
Proto-oncogene tyrosine-protein kinase Src

5

20

Small-scale

0.906

High

452385

GRB2
Growth factor receptor-bound protein 2

4

20

Small-scale

0.899

High

452333

PGFRB
Platelet-derived growth factor receptor beta

4

18

Small-scale

0.882

High

452381

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

3

13

Small-scale

0.866

High

208979

NCK2
Cytoplasmic protein NCK2

3

20

Small-scale

0.861

High

411953

FYN
Tyrosine-protein kinase Fyn

4

20

Small-scale

0.861

High

452346

PTN1
Tyrosine-protein phosphatase non-receptor type 1

3

20

Small-scale

0.834

High

452398

PTN12
Tyrosine-protein phosphatase non-receptor type 12

3

20

Small-scale

0.829

High

452405

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

2

20

Small-scale

0.825

High

452401

ACK1
Activated CDC42 kinase 1

2

20

Small-scale

0.819

High

452344

NCK1
SH2/SH3 adapter protein NCK1

3

20

Small-scale

0.817

High

452363

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.812

High

452408

SLAP1
Src-like-adapter

2

20

Small-scale

0.759

High

383550

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

Small-scale

0.757

High

452424

GRB7
Growth factor receptor-bound protein 7

1

20

Small-scale

0.757

High

337818

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.754

High

452467

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

Small-scale

0.754

High

129176

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

2

20

Small-scale

0.737

High

452371

CRK
Adapter molecule crk

1

20

Small-scale

0.734

High

452342

VAV
Proto-oncogene vav

2

20

Small-scale

0.727

High

452337

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.724

High

452354

KS6B1
Ribosomal protein S6 kinase beta-1

1

16

Small-scale

0.724

High

153861

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

4

20

Small-scale

0.704

High

452377

TPTE
Putative tyrosine-protein phosphatase TPTE

1

13

High-throughput

0.698

High

145969

SH2B2
SH2B adapter protein 2

1

20

Small-scale

0.691

High

382273

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

12

High-throughput

0.691

High

426979

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

17

High-throughput

0.691

High

452366

BMR1A
Bone morphogenetic protein receptor type-1A

1

10

High-throughput

0.691

High

452406

MYO1E
Unconventional myosin-Ie

1

7

High-throughput

0.691

High

452411

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

15

High-throughput

0.691

High

452420

AVR2B
Activin receptor type-2B

1

10

High-throughput

0.691

High

452448

FGD6
FYVE, RhoGEF and PH domain-containing protein 6

1

20

High-throughput

0.691

High

452497

FND3A
Fibronectin type-III domain-containing protein 3A

1

8

High-throughput

0.691

High

452435

KLH12
Kelch-like protein 12

3

2

High-throughput

0.675

High

452389

FOXK1
Forkhead box protein K1

3

4

High-throughput

0.675

High

299549

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

10

Small-scale

0.665

High

376361

PDGFA
Platelet-derived growth factor subunit A

1

20

Small-scale

0.665

High

337317

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.647

High

373569

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.647

High

441166

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

20

High-throughput

0.647

High

452355

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

17

High-throughput

0.647

High

452356

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

1

20

High-throughput

0.647

High

452357

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

17

High-throughput

0.647

High

452370

ABL2
Tyrosine-protein kinase ABL2

1

20

Small-scale

0.647

High

452423

GRB14
Growth factor receptor-bound protein 14

1

20

Small-scale

0.647

High

452425

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.647

High

452426

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

18

High-throughput

0.647

High

452433

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

18

High-throughput

0.647

High

452491

KS6B2
Ribosomal protein S6 kinase beta-2

1

16

Small-scale

0.647

High

452498

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

20

High-throughput

0.647

High

441405

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.646

High

452395

TIE2
Angiopoietin-1 receptor

1

20

High-throughput

0.646

High

452392

FOXK2
Forkhead box protein K2

2

5

High-throughput

0.628

High

452416

ATR
Serine/threonine-protein kinase ATR

2

15

High-throughput

0.628

High

452444

DEP1A
DEP domain-containing protein 1A

2

1

High-throughput

0.628

High

452499

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

20

High-throughput

0.618

High

276989

STAM2
Signal transducing adapter molecule 2

1

20

High-throughput

0.618

High

384142

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.618

High

452340

IL1R1
Interleukin-1 receptor type 1

1

17

Small-scale

0.618

High

452349

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

5

Small-scale

0.618

High

452358

ARBK1
Beta-adrenergic receptor kinase 1

1

15

Small-scale

0.618

High

452362

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

452364

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.618

High

452365

VGFR2
Vascular endothelial growth factor receptor 2

1

18

Small-scale

0.618

High

452369

STA5A
Signal transducer and activator of transcription 5A

1

14

Small-scale

0.618

High

452375

VAV2
Guanine nucleotide exchange factor VAV2

1

20

Small-scale

0.618

High

452396

DYST
Dystonin

1

16

High-throughput

0.618

High

452409

PTK7
Inactive tyrosine-protein kinase 7

1

19

High-throughput

0.618

High

452413

SNTB2
Beta-2-syntrophin

1

20

High-throughput

0.618

High

452414

GAB1
GRB2-associated-binding protein 1

1

13

High-throughput

0.618

High

452415

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.618

High

452421

SNTB1
Beta-1-syntrophin

1

20

High-throughput

0.618

High

452455

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

6

High-throughput

0.618

High

452457

EHBP1
EH domain-binding protein 1

1

12

High-throughput

0.618

High

452486

PDGFC
Platelet-derived growth factor C

1

10

Small-scale

0.618

High

452495

VAV3
Guanine nucleotide exchange factor VAV3

1

20

Small-scale

0.618

High

431450

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.611

High

452442

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.580

High

433221

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.575

High

452410

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.575

High

452430

TRIP6
Thyroid receptor-interacting protein 6

1

7

High-throughput

0.573

High

452397

CAV1
Caveolin-1

1

4

Small-scale

0.561

High

452472

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

14

Small-scale

0.561

High

280513

KRT34
Keratin, type I cuticular Ha4

2

3

High-throughput

0.553

High

452380

KR109
Keratin-associated protein 10-9

2

6

High-throughput

0.553

High

452427

K1H1
Keratin, type I cuticular Ha1

2

3

High-throughput

0.553

High

452440

PPM1L
Protein phosphatase 1L

1

10

High-throughput

0.541

High

452471

LCOR
Ligand-dependent corepressor

1

1

High-throughput

0.541

High

452372

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

13

High-throughput

0.536

High

452428

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

17

Small-scale

0.536

High

152361

ABCD4
Lysosomal cobalamin transporter ABCD4

1

1

High-throughput

0.536

High

255278

HIP1R
Huntingtin-interacting protein 1-related protein

1

2

High-throughput

0.536

High

280187

CBPD
Carboxypeptidase D

1

4

High-throughput

0.536

High

315177

CNEP1
CTD nuclear envelope phosphatase 1

1

6

High-throughput

0.536

High

452334

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

8

High-throughput

0.536

High

452431

CDC37
Hsp90 co-chaperone Cdc37

1

15

High-throughput

0.536

High

452432

HIF1A
Hypoxia-inducible factor 1-alpha

1

4

High-throughput

0.536

High

452453

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

2

High-throughput

0.536

High

452475

PKP2
Plakophilin-2

1

19

High-throughput

0.536

High

452480

NRSN2
Neurensin-2

1

2

High-throughput

0.536

High

452487

HELLS
Lymphoid-specific helicase

1

10

High-throughput

0.536

High

452490

BCLF1
Bcl-2-associated transcription factor 1

1

2

High-throughput

0.536

High

270255

LRP6
Low-density lipoprotein receptor-related protein 6

1

4

Small-scale

0.515

High

452494

ERRFI
ERBB receptor feedback inhibitor 1

1

9

Small-scale

0.515

High

393980

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.515

High

245871

HUS1
Checkpoint protein HUS1

1

0

High-throughput

0.513

High

452412

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

High-throughput

0.513

High

452454

LACC1
Purine nucleoside phosphorylase LACC1

1

0

High-throughput

0.513

High

452468

INT4
Integrator complex subunit 4

1

0

High-throughput

0.513

High

452474

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.513

High

452378

CAV3
Caveolin-3

1

4

Small-scale

0.501

High

162356

XPO1
Exportin-1

1

14

High-throughput

0.500

High

225485

PCDH7
Protocadherin-7

1

6

High-throughput

0.500

High

282399

STC2
Stanniocalcin-2

1

1

High-throughput

0.500

High

452335

CLUS
Clusterin

1

3

High-throughput

0.500

High

452345

EPCAM
Epithelial cell adhesion molecule

1

3

High-throughput

0.500

High

452360

CALX
Calnexin

1

18

High-throughput

0.500

High

452383

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

7

High-throughput

0.500

High

452388

PRKDC
DNA-dependent protein kinase catalytic subunit

1

14

High-throughput

0.500

High

452393

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

16

High-throughput

0.500

High

452441

UBR4
E3 ubiquitin-protein ligase UBR4

1

3

High-throughput

0.500

High

452447

QSOX2
Sulfhydryl oxidase 2

1

20

High-throughput

0.500

High

452460

PO210
Nuclear pore membrane glycoprotein 210

1

2

High-throughput

0.500

High

452477

NTPCR
Cancer-related nucleoside-triphosphatase

1

7

High-throughput

0.500

High

452479

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.500

High

452489

FANCI
Fanconi anemia group I protein

1

8

High-throughput

0.500

High

452492

DJB11
DnaJ homolog subfamily B member 11

1

17

High-throughput

0.500

High

452476

KR412
Keratin-associated protein 4-12

1

6

High-throughput

0.494

High

195675

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

1

High-throughput

0.489

High

452352

CD9
CD9 antigen

1

7

High-throughput

0.484

High

344419

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.479

High

68127

F1712
Protein FAM171A2

1

16

High-throughput

0.479

High

124362

HIP1
Huntingtin-interacting protein 1

1

2

Small-scale

0.479

High

135760

P3C2B
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

1

20

Small-scale

0.479

High

159856

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.479

High

240337

SNX2
Sorting nexin-2

1

15

Small-scale

0.479

High

240682

USO1
General vesicular transport factor p115

1

7

High-throughput

0.479

High

307878

SNX4
Sorting nexin-4

1

15

Small-scale

0.479

High

310474

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

14

High-throughput

0.479

High

315634

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.479

High

396557

ITB3
Integrin beta-3

1

11

Small-scale

0.479

High

417477

PYGL
Glycogen phosphorylase, liver form

1

4

High-throughput

0.479

High

437239

4F2
Amino acid transporter heavy chain SLC3A2

1

3

High-throughput

0.479

High

437821

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

452336

PYGB
Glycogen phosphorylase, brain form

1

4

High-throughput

0.479

High

452341

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.479

High

452347

ARF4
ADP-ribosylation factor 4

1

15

High-throughput

0.479

High

452351

S1PR1
Sphingosine 1-phosphate receptor 1

1

4

Small-scale

0.479

High

452367

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

4

High-throughput

0.479

High

452368

ETV6
Transcription factor ETV6

1

2

Small-scale

0.479

High

452373

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

12

High-throughput

0.479

High

452374

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

8

High-throughput

0.479

High

452376

COPA
Coatomer subunit alpha

1

13

Small-scale

0.479

High

452382

RAB10
Ras-related protein Rab-10

1

3

High-throughput

0.479

High

452386

RAC1
Ras-related C3 botulinum toxin substrate 1

1

4

High-throughput

0.479

High

452387

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

452390

CLH1
Clathrin heavy chain 1

1

2

Small-scale

0.479

High

452394

IRF8
Interferon regulatory factor 8

1

2

Small-scale

0.479

High

452400

CKAP4
Cytoskeleton-associated protein 4

1

6

High-throughput

0.479

High

452402

GOGA3
Golgin subfamily A member 3

1

8

High-throughput

0.479

High

452403

GOGA2
Golgin subfamily A member 2

1

7

High-throughput

0.479

High

452404

MFGM
Lactadherin

1

9

Small-scale

0.479

High

452407

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

Small-scale

0.479

High

452417

STIM1
Stromal interaction molecule 1

1

9

High-throughput

0.479

High

452418

SNX1
Sorting nexin-1

1

16

Small-scale

0.479

High

452419

RIN1
Ras and Rab interactor 1

1

20

Small-scale

0.479

High

452429

TRIPB
Thyroid receptor-interacting protein 11

1

16

High-throughput

0.479

High

452439

TGO1
Transport and Golgi organization protein 1 homolog

1

6

High-throughput

0.479

High

452443

ATD3B
ATPase family AAA domain-containing protein 3B

1

5

High-throughput

0.479

High

452445

F1711
Protein FAM171A1

1

16

High-throughput

0.479

High

452446

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

6

High-throughput

0.479

High

452449

ZFY16
Zinc finger FYVE domain-containing protein 16

1

20

High-throughput

0.479

High

452452

LAP4B
Lysosomal-associated transmembrane protein 4B

1

2

Small-scale

0.479

High

452459

DLG5
Disks large homolog 5

1

12

High-throughput

0.479

High

452461

FRS2
Fibroblast growth factor receptor substrate 2

1

13

Small-scale

0.479

High

452462

PDC6I
Programmed cell death 6-interacting protein

1

5

Small-scale

0.479

High

452463

SCFD1
Sec1 family domain-containing protein 1

1

9

High-throughput

0.479

High

452466

ARHG2
Rho guanine nucleotide exchange factor 2

1

20

High-throughput

0.479

High

452469

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

452470

CK5P3
CDK5 regulatory subunit-associated protein 3

1

4

High-throughput

0.479

High

452478

RFIP5
Rab11 family-interacting protein 5

1

8

High-throughput

0.479

High

452481

REXO4
RNA exonuclease 4

1

2

High-throughput

0.479

High

452482

GCP60
Golgi resident protein GCP60

1

9

High-throughput

0.479

High

452483

GORS2
Golgi reassembly-stacking protein 2

1

9

High-throughput

0.479

High

452484

RHOF
Rho-related GTP-binding protein RhoF

1

4

High-throughput

0.479

High

452485

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

452493

SEC63
Translocation protein SEC63 homolog

1

18

High-throughput

0.479

High

452500

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.479

High

452501

SRPRB
Signal recognition particle receptor subunit beta

1

20

High-throughput

0.479

High

452359

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

Small-scale

0.458

High

452391

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

130411

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

9

High-throughput

0.457

High

296858

LTN1
E3 ubiquitin-protein ligase listerin

1

1

High-throughput

0.457

High

452436

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

7

High-throughput

0.457

High

452450

MON2
Protein MON2 homolog

1

5

High-throughput

0.457

High

452496

DJC16
DnaJ homolog subfamily C member 16

1

20

High-throughput

0.457

High

152235

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

9

High-throughput

0.445

High

326013

TSN15
Tetraspanin-15

1

7

High-throughput

0.445

High

452353

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.445

High

452384

TSN5
Tetraspanin-5

1

8

High-throughput

0.445

High

452437

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.445

High

452438

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.445

High

452456

ST134
Putative protein FAM10A4

1

6

High-throughput

0.445

High

164093

ARHGA
Rho guanine nucleotide exchange factor 10

1

20

High-throughput

0.437

High

314202

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

3

High-throughput

0.437

High

315509

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.437

High

452339

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.437

High

452422

SEPT6
Septin-6

1

18

High-throughput

0.437

High

452434

INF2
Inverted formin-2

1

1

High-throughput

0.437

High

452464

SEPT8
Septin-8

1

18

High-throughput

0.437

High

452465

RT31
Small ribosomal subunit protein mS31

1

5

High-throughput

0.437

High

452473

CDCA3
Cell division cycle-associated protein 3

1

6

High-throughput

0.437

High

452451

NOP9
Nucleolar protein 9

2

0

High-throughput

0.328

High

452379

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.316

High

452458

CEP76
Centrosomal protein of 76 kDa

2

0

High-throughput

0.316

High

452488

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024