Protein: CLOCK
Circadian locomoter output cycles protein kaput (dCLOCK) (dPAS1)

Gene: CLOCK, Clk
Organism: Drosophila melanogaster
Interactions: 36
UniProt ID: O61735

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003053 - circadian regulation of heart rate
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

263790

CYCL
Protein cycle

12

20

Small-scale

0.976

High

263802

PER
Period circadian protein

11

20

Small-scale

0.968

High

263808

TIM
Protein timeless

5

1

Small-scale

0.696

High

263800

DCO
Discs overgrown protein kinase

2

9

Small-scale

0.584

High

263807

BRM
ATP-dependent helicase brm

2

9

Small-scale

0.584

High

263803

CSK2A
Casein kinase II subunit alpha

1

5

Small-scale

0.536

High

263804

CSK2B
Casein kinase II subunit beta

1

5

Small-scale

0.536

High

263812

SEM1A
Semaphorin-1A

1

1

High-throughput

0.489

High

92271

D3DML3
Connector of kinase to AP-1, isoform E

1

6

Small-scale

0.479

High

121959

M9PH39
histone acetyltransferase

1

20

Small-scale

0.479

High

263805

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

4

Small-scale

0.479

High

263809

NONA
Protein no-on-transient A

1

3

Small-scale

0.479

High

263811

Q24090
GH08712p

1

1

Small-scale

0.479

High

263814

Q7JQX9
FI14001p1

1

1

Small-scale

0.479

High

263815

Q7K012
Brahma associated protein 55kD

1

2

Small-scale

0.479

High

263816

Q7KJA9
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

Small-scale

0.479

High

263823

Q9VF03
Brahma associated protein 155 kDa

1

9

Small-scale

0.479

High

263826

BAP60
Brahma-associated protein of 60 kDa

1

1

Small-scale

0.479

High

263828

Q9W384
Brahma associated protein 111kD

1

7

Small-scale

0.479

High

263801

O96676
BcDNA.GH12350

1

0

Small-scale

0.458

High

263819

Q8IRD5
AT25231p

1

0

Small-scale

0.458

High

263820

Q9VDC9
protein O-GlcNAcase

1

0

Small-scale

0.458

High

262704

TENM
Teneurin-m

1

2

High-throughput

0.445

High

263591

FLOT2
Flotillin-2

1

1

High-throughput

0.445

High

263806

SGG
Protein kinase shaggy

1

2

High-throughput

0.445

High

263822

Q9VEB1
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.445

High

263824

Q9VH81
protein-serine/threonine phosphatase

1

10

High-throughput

0.445

High

263821

Q9VDD8
Ubiquitin carboxyl-terminal hydrolase

1

7

Small-scale

0.437

High

263818

Q8IPU8
BNIP3, isoform B

1

0

High-throughput

0.426

High

263829

4EBP
Eukaryotic translation initiation factor 4E-binding protein

1

0

High-throughput

0.426

High

99355

F3YDN6
RE08495p

1

1

High-throughput

0.407

High

263810

Q0E8S4
Semaphorin-1A

1

1

High-throughput

0.407

High

263817

Q7KN04
Spondin-1

1

3

High-throughput

0.407

High

263813

NETB
Netrin-B

1

0

High-throughput

0.232

Low

263825

Q9VMT1
receptor protein serine/threonine kinase

1

0

High-throughput

0.232

Low

263827

Q9W258
Babos, isoform A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025