Protein: UBS3B
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)

Gene: UBS3B, UBASH3B
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q8TF42

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0009968 - negative regulation of signal transduction
GO:0031625 - ubiquitin protein ligase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

338742

EGFR
Epidermal growth factor receptor

10

20

Small-scale

0.968

High

476098

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

6

15

Small-scale

0.937

High

1257117

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

4

16

High-throughput

0.896

High

796615

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.843

High

610459

CBL
E3 ubiquitin-protein ligase CBL

5

20

Small-scale

0.823

High

782811

CSK
Tyrosine-protein kinase CSK

2

20

High-throughput

0.789

High

199520

EFS
Embryonal Fyn-associated substrate

2

18

High-throughput

0.783

High

310071

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

2

3

High-throughput

0.783

High

1257124

AURKB
Aurora kinase B

1

7

Small-scale

0.724

High

1257129

ZN363
RING finger and CHY zinc finger domain-containing protein 1

5

0

High-throughput

0.694

High

789033

TXK
Tyrosine-protein kinase TXK

1

20

High-throughput

0.691

High

802674

CRK
Adapter molecule crk

1

20

High-throughput

0.691

High

1257127

ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

1

16

High-throughput

0.691

High

228160

PRKN
E3 ubiquitin-protein ligase parkin

1

16

Small-scale

0.681

High

1065143

DAZP2
DAZ-associated protein 2

3

2

High-throughput

0.675

High

1257134

VP37B
Vacuolar protein sorting-associated protein 37B

3

10

High-throughput

0.675

High

1050470

DOC2A
Double C2-like domain-containing protein alpha

6

3

High-throughput

0.672

High

985565

Q05BL1
TP53BP2 protein

1

13

High-throughput

0.665

High

924723

GRB2
Growth factor receptor-bound protein 2

3

20

Small-scale

0.650

High

135942

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

7

Small-scale

0.647

High

849383

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

6

Small-scale

0.647

High

851854

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

6

Small-scale

0.647

High

895859

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

6

Small-scale

0.647

High

908868

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

Small-scale

0.647

High

919798

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

6

Small-scale

0.647

High

1028402

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

5

Small-scale

0.647

High

1128662

F209A
Protein FAM209A

3

0

High-throughput

0.629

High

1043711

ASPP2
Apoptosis-stimulating of p53 protein 2

1

15

High-throughput

0.621

High

337511

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.618

High

883371

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

16

High-throughput

0.618

High

924089

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

8

High-throughput

0.618

High

1027618

CBLB
E3 ubiquitin-protein ligase CBL-B

3

20

High-throughput

0.616

High

724933

MYH9
Myosin-9

2

7

High-throughput

0.611

High

1257120

F168A
Protein FAM168A

3

2

High-throughput

0.609

High

666141

SHC1
SHC-transforming protein 1

3

20

Small-scale

0.606

High

126946

WASL
Actin nucleation-promoting factor WASL

2

20

High-throughput

0.606

High

232372

KDM1A
Lysine-specific histone demethylase 1A

2

2

High-throughput

0.606

High

278310

PIAS2
E3 SUMO-protein ligase PIAS2

2

1

High-throughput

0.606

High

551218

ITF2
Transcription factor 4

2

1

High-throughput

0.606

High

594595

PSB1
Proteasome subunit beta type-1

2

2

High-throughput

0.606

High

638357

RBTN2
Rhombotin-2

2

10

High-throughput

0.606

High

981658

REL
Proto-oncogene c-Rel

2

5

High-throughput

0.606

High

1012285

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

1087917

PTN21
Tyrosine-protein phosphatase non-receptor type 21

2

20

High-throughput

0.606

High

1134379

KPRP
Keratinocyte proline-rich protein

2

3

High-throughput

0.606

High

1238388

DTX3
Probable E3 ubiquitin-protein ligase DTX3

2

6

High-throughput

0.606

High

1257126

AP4AT
AP-4 complex accessory subunit Tepsin

2

2

High-throughput

0.606

High

1257138

RN216
E3 ubiquitin-protein ligase RNF216

2

3

High-throughput

0.606

High

504460

HSP7C
Heat shock cognate 71 kDa protein

2

7

High-throughput

0.584

High

891919

ACTB
Actin, cytoplasmic 1

2

20

High-throughput

0.584

High

1257123

KAT5
Histone acetyltransferase KAT5

2

0

High-throughput

0.580

High

383895

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.575

High

994661

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.575

High

1235087

CCD33
Coiled-coil domain-containing protein 33

2

1

High-throughput

0.574

High

208172

SPY2
Protein sprouty homolog 2

1

20

High-throughput

0.573

High

1257136

DMRT3
Doublesex- and mab-3-related transcription factor 3

1

3

High-throughput

0.573

High

69209

A9UF07
non-specific protein-tyrosine kinase

1

20

High-throughput

0.559

High

474629

PRR35
Proline-rich protein 35

2

1

High-throughput

0.553

High

538736

HXB2
Homeobox protein Hox-B2

2

4

High-throughput

0.553

High

1257132

LZTS2
Leucine zipper putative tumor suppressor 2

2

20

High-throughput

0.553

High

1257137

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.553

High

1257139

DLGP2
Disks large-associated protein 2

2

14

High-throughput

0.553

High

506628

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.553

High

176476

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

20

High-throughput

0.536

High

297386

MYO1D
Unconventional myosin-Id

1

9

High-throughput

0.536

High

396773

S10A8
Protein S100-A8

1

4

High-throughput

0.536

High

608599

H1T
Histone H1t

1

6

High-throughput

0.536

High

609966

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

9

High-throughput

0.536

High

878695

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

13

High-throughput

0.536

High

971283

H11
Histone H1.1

1

6

High-throughput

0.536

High

1257122

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.536

High

1257141

ERRFI
ERBB receptor feedback inhibitor 1

1

12

High-throughput

0.536

High

1170505

S2548
Solute carrier family 25 member 48

1

5

High-throughput

0.523

High

1257140

MSRA
Mitochondrial peptide methionine sulfoxide reductase

1

0

High-throughput

0.513

High

1257133

RNF41
E3 ubiquitin-protein ligase NRDP1

1

15

Small-scale

0.512

High

1042130

CUL3
Cullin-3

1

9

Small-scale

0.501

High

360655

SPTA1
Spectrin alpha chain, erythrocytic 1

1

16

High-throughput

0.489

High

815189

NPTX2
Neuronal pentraxin-2

1

1

High-throughput

0.489

High

946416

EREP3
Protein ENTREP3

1

2

High-throughput

0.489

High

995993

DSC1
Desmocollin-1

1

7

High-throughput

0.489

High

1154405

PRR27
Proline-rich protein 27

1

10

High-throughput

0.489

High

1257135

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

1

High-throughput

0.489

High

1257130

PKP4
Plakophilin-4

1

5

High-throughput

0.481

High

211621

ACTN4
Alpha-actinin-4

1

12

High-throughput

0.479

High

308921

KI20A
Kinesin-like protein KIF20A

1

13

Small-scale

0.479

High

320216

ERR2
Steroid hormone receptor ERR2

1

8

High-throughput

0.479

High

359388

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.479

High

359518

K2C6A
Keratin, type II cytoskeletal 6A

1

20

High-throughput

0.479

High

380655

K2C1
Keratin, type II cytoskeletal 1

1

19

High-throughput

0.479

High

409176

K2C8
Keratin, type II cytoskeletal 8

1

20

High-throughput

0.479

High

428331

TBB5
Tubulin beta chain

1

5

High-throughput

0.479

High

432100

HS90A
Heat shock protein HSP 90-alpha

1

7

High-throughput

0.479

High

438389

HS90B
Heat shock protein HSP 90-beta

1

7

High-throughput

0.479

High

445094

K1C16
Keratin, type I cytoskeletal 16

1

20

High-throughput

0.479

High

489173

H14
Histone H1.4

1

6

High-throughput

0.479

High

502359

BIP
Endoplasmic reticulum chaperone BiP

1

10

High-throughput

0.479

High

531401

K1C10
Keratin, type I cytoskeletal 10

1

20

High-throughput

0.479

High

531608

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.479

High

535490

GFAP
Glial fibrillary acidic protein

1

20

High-throughput

0.479

High

557747

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.479

High

559456

H13
Histone H1.3

1

6

High-throughput

0.479

High

559855

H12
Histone H1.2

1

6

High-throughput

0.479

High

573391

TCPA
T-complex protein 1 subunit alpha

1

6

High-throughput

0.479

High

640557

DDX6
Probable ATP-dependent RNA helicase DDX6

1

7

High-throughput

0.479

High

681534

DNJA1
DnaJ homolog subfamily A member 1

1

4

High-throughput

0.479

High

682905

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

14

High-throughput

0.479

High

714029

HS71L
Heat shock 70 kDa protein 1-like

1

7

High-throughput

0.479

High

724112

K1C9
Keratin, type I cytoskeletal 9

1

20

High-throughput

0.479

High

725206

MYH10
Myosin-10

1

7

High-throughput

0.479

High

729142

K22E
Keratin, type II cytoskeletal 2 epidermal

1

20

High-throughput

0.479

High

770952

TCPZ
T-complex protein 1 subunit zeta

1

6

High-throughput

0.479

High

809374

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

8

High-throughput

0.479

High

842971

TCPQ
T-complex protein 1 subunit theta

1

9

High-throughput

0.479

High

855152

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

13

High-throughput

0.479

High

929939

ACTG
Actin, cytoplasmic 2

1

20

High-throughput

0.479

High

933289

TBA1B
Tubulin alpha-1B chain

1

6

High-throughput

0.479

High

962238

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.479

High

963374

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

18

High-throughput

0.479

High

967296

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

1038569

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.479

High

1059754

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

Small-scale

0.479

High

1170964

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1205248

K2C73
Keratin, type II cytoskeletal 73

1

20

High-throughput

0.479

High

1257121

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.479

High

1257131

TCPH
T-complex protein 1 subunit eta

1

7

High-throughput

0.479

High

265229

SAP30
Histone deacetylase complex subunit SAP30

1

0

Small-scale

0.458

High

380504

K2C6B
Keratin, type II cytoskeletal 6B

1

20

High-throughput

0.437

High

826793

TCPG
T-complex protein 1 subunit gamma

1

7

High-throughput

0.437

High

980294

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.437

High

995406

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.437

High

1024055

ACACA
Acetyl-CoA carboxylase 1

1

1

High-throughput

0.437

High

1045462

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

16

High-throughput

0.437

High

1140440

K2C79
Keratin, type II cytoskeletal 79

1

20

High-throughput

0.437

High

1257119

TCPW
T-complex protein 1 subunit zeta-2

1

8

High-throughput

0.437

High

1257142

COR1C
Coronin-1C

1

6

High-throughput

0.437

High

1047175

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

991827

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

5

Small-scale

0.408

High

1257125

CC74B
Coiled-coil domain-containing protein 74B

2

0

High-throughput

0.316

High

1257128

BBC3B
Bcl-2-binding component 3, isoforms 3/4

2

0

High-throughput

0.316

High

1231978

CBARP
Voltage-dependent calcium channel beta subunit-associated regulatory protein

1

0

High-throughput

0.279

Low

946575

DCD
Dermcidin

1

0

High-throughput

0.249

Low

1127376

T255A
Transmembrane protein 255A

1

0

High-throughput

0.249

Low

1257118

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024