Protein: PKHB2
Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2)

Gene: PKHB2, PLEKHB2
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q96CS7

Gene Ontology (top 5):
GO:0005547 - phosphatidylinositol-3,4,5-trisphosphate binding
GO:0016020 - membrane
GO:0045595 - regulation of cell differentiation
GO:0055038 - recycling endosome membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

296548

STAM2
Signal transducing adapter molecule 2

3

2

High-throughput

0.779

High

932702

EMP1
Epithelial membrane protein 1

2

1

High-throughput

0.606

High

987156

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

2

High-throughput

0.606

High

1386466

GGA3
ADP-ribosylation factor-binding protein GGA3

2

2

High-throughput

0.606

High

226351

SNG1
Synaptogyrin-1

2

0

High-throughput

0.580

High

760767

CD68
Macrosialin

2

0

High-throughput

0.580

High

1357632

SFT2A
Vesicle transport protein SFT2A

2

0

High-throughput

0.580

High

1386462

UBXN6
UBX domain-containing protein 6

2

0

High-throughput

0.580

High

169693

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

2

High-throughput

0.553

High

277130

PROP1
Homeobox protein prophet of Pit-1

2

1

High-throughput

0.553

High

329477

EPN2
Epsin-2

2

1

High-throughput

0.553

High

507307

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

2

High-throughput

0.553

High

508412

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

2

High-throughput

0.553

High

932751

EMP3
Epithelial membrane protein 3

2

1

High-throughput

0.553

High

987444

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

2

High-throughput

0.553

High

1386461

GLIS2
Zinc finger protein GLIS2

2

1

High-throughput

0.553

High

1386464

HEYL
Hairy/enhancer-of-split related with YRPW motif-like protein

2

2

High-throughput

0.553

High

1386467

UBQL2
Ubiquilin-2

2

2

High-throughput

0.553

High

1386468

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

2

2

High-throughput

0.553

High

1098829

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

0

Small-scale

0.541

High

1029901

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.541

High

155017

BHE40
Class E basic helix-loop-helix protein 40

1

2

High-throughput

0.523

High

1386469

EPN1
Epsin-1

1

1

High-throughput

0.523

High

564184

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

63687

A5PKU2
TUSC5 protein

1

1

High-throughput

0.515

High

1107453

BIRC2
Baculoviral IAP repeat-containing protein 2

1

0

High-throughput

0.513

High

1312114

TARG1
Trafficking regulator of GLUT4 1

1

1

High-throughput

0.481

High

300458

KRT34
Keratin, type I cuticular Ha4

1

3

High-throughput

0.470

High

1007537

KRT85
Keratin, type II cuticular Hb5

1

1

High-throughput

0.470

High

1146091

K1H1
Keratin, type I cuticular Ha1

1

3

High-throughput

0.470

High

1386465

KRT82
Keratin, type II cuticular Hb2

1

1

High-throughput

0.470

High

1386455

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

0

High-throughput

0.458

High

1386459

LOXE3
Hydroperoxide isomerase ALOXE3

1

0

High-throughput

0.458

High

1242196

NPAL3
NIPA-like protein 3

1

2

High-throughput

0.445

High

1273785

NIPA1
Magnesium transporter NIPA1

1

2

High-throughput

0.445

High

1386456

MF14A
Hippocampus abundant transcript 1 protein

1

2

High-throughput

0.445

High

190453

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.426

High

1340548

MFSD8
Major facilitator superfamily domain-containing protein 8

1

2

High-throughput

0.407

High

733851

CDD
Cytidine deaminase

3

0

High-throughput

0.352

High

1139103

DAZP2
DAZ-associated protein 2

3

0

High-throughput

0.352

High

1241233

CA094
Uncharacterized protein C1orf94

3

0

High-throughput

0.352

High

1386457

CGRF1
Cell growth regulator with RING finger domain protein 1

3

0

High-throughput

0.347

High

1386463

TM231
Transmembrane protein 231

3

0

High-throughput

0.347

High

574413

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

0

High-throughput

0.316

High

706043

CXB2
Gap junction beta-2 protein

2

0

High-throughput

0.316

High

943808

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

0

High-throughput

0.316

High

1005628

PITX1
Pituitary homeobox 1

2

0

High-throughput

0.316

High

1213526

UBAP2
Ubiquitin-associated protein 2

2

0

High-throughput

0.316

High

1218625

OTU1
Ubiquitin thioesterase OTU1

2

0

High-throughput

0.316

High

1250432

FX4L3
Forkhead box protein D4-like 3

2

0

High-throughput

0.316

High

1259267

MED25
Mediator of RNA polymerase II transcription subunit 25

2

0

High-throughput

0.316

High

1277206

POGZ
Pogo transposable element with ZNF domain

2

0

High-throughput

0.316

High

1286704

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

2

0

High-throughput

0.316

High

1290929

TAXB1
Tax1-binding protein 1

2

0

High-throughput

0.316

High

1325112

MTURN
Maturin

2

0

High-throughput

0.316

High

1329239

CLD19
Claudin-19

2

0

High-throughput

0.316

High

1329562

ZFN2A
AN1-type zinc finger protein 2A

2

0

High-throughput

0.316

High

1352336

RHBL4
Rhomboid-related protein 4

2

0

High-throughput

0.316

High

1364809

F168A
Protein FAM168A

2

0

High-throughput

0.316

High

1386452

OTUB2
Ubiquitin thioesterase OTUB2

2

0

High-throughput

0.316

High

1386453

DCNL1
DCN1-like protein 1

2

0

High-throughput

0.316

High

1386454

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.316

High

1386458

UBAC1
Ubiquitin-associated domain-containing protein 1

2

0

High-throughput

0.316

High

1154333

CYTM
Cystatin-M

2

0

High-throughput

0.313

High

127716

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

0

High-throughput

0.279

Low

639286

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

0

High-throughput

0.279

Low

1090846

TRAF2
TNF receptor-associated factor 2

1

0

High-throughput

0.279

Low

1137925

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.279

Low

1369462

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.279

Low

1386470

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.279

Low

1370051

RENT1
Regulator of nonsense transcripts 1

1

0

High-throughput

0.265

Low

586338

ZEP1
Zinc finger protein 40

1

0

High-throughput

0.251

Low

1249097

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1256971

FBX50
F-box only protein 50

1

0

High-throughput

0.249

Low

1330900

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.249

Low

138268

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.238

Low

1250454

MCAF1
Activating transcription factor 7-interacting protein 1

1

0

High-throughput

0.238

Low

1239532

ZNT6
Zinc transporter 6

1

0

High-throughput

0.232

Low

1386460

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025