Protein: CASP9
Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]

Gene: CASP9
Organism: Homo sapiens
Interactions: 68
UniProt ID: P55211

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001822 - kidney development
GO:0002931 - response to ischemia
GO:0004197 - cysteine-type endopeptidase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

876972

XIAP
E3 ubiquitin-protein ligase XIAP

35

20

Small-scale

0.995

High

152863

APAF
Apoptotic protease-activating factor 1

21

5

Small-scale

0.988

High

876981

BIRC2
Baculoviral IAP repeat-containing protein 2

11

20

Small-scale

0.980

High

788170

CASP3
Caspase-3

9

17

Small-scale

0.973

High

876997

BIRC7
Baculoviral IAP repeat-containing protein 7

7

20

Small-scale

0.969

High

877004

BIRC6
Baculoviral IAP repeat-containing protein 6

5

20

Small-scale

0.934

High

876998

BIRC8
Baculoviral IAP repeat-containing protein 8

5

20

Small-scale

0.925

High

876980

BIRC3
Baculoviral IAP repeat-containing protein 3

5

20

Small-scale

0.922

High

876968

CASP9
Caspase-9

3

20

Small-scale

0.855

High

876934

CASP7
Caspase-7

2

19

Small-scale

0.812

High

876984

CASP8
Caspase-8

2

20

Small-scale

0.778

High

177664

BIRC5
Baculoviral IAP repeat-containing protein 5

2

20

Small-scale

0.754

High

877001

NLRP1
NACHT, LRR and PYD domains-containing protein 1

2

20

Small-scale

0.754

High

876979

ILK
Integrin-linked protein kinase

1

2

Small-scale

0.665

High

877005

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

20

Small-scale

0.665

High

876987

Q6PIA0
Baculoviral IAP repeat-containing 8

1

20

High-throughput

0.665

High

876977

BIRC1
Baculoviral IAP repeat-containing protein 1

1

20

Small-scale

0.647

High

876988

CASPC
Inactive caspase-12

1

20

Small-scale

0.647

High

876994

CASPA
Caspase-10

1

20

Small-scale

0.647

High

793626

DCC
Netrin receptor DCC

3

1

Small-scale

0.640

High

876975

B2CL1
Bcl-2-like protein 1

1

8

Small-scale

0.618

High

876995

RNF34
E3 ubiquitin-protein ligase RNF34

1

20

Small-scale

0.618

High

877003

B2L10
Bcl-2-like protein 10

1

1

Small-scale

0.618

High

877006

CARD8
Caspase recruitment domain-containing protein 8

1

10

Small-scale

0.618

High

337409

ABL1
Tyrosine-protein kinase ABL1

1

1

Small-scale

0.578

High

388340

HSPB1
Heat shock protein beta-1

2

10

High-throughput

0.571

High

423188

PDIA1
Protein disulfide-isomerase

2

3

High-throughput

0.571

High

449620

HMGB1
High mobility group protein B1

2

3

High-throughput

0.571

High

876969

IF4A1
Eukaryotic initiation factor 4A-I

2

1

High-throughput

0.571

High

876970

ARP3
Actin-related protein 3

2

6

High-throughput

0.571

High

876973

AKA12
A-kinase anchor protein 12

2

1

High-throughput

0.571

High

876989

TRI72
Tripartite motif-containing protein 72

2

3

High-throughput

0.571

High

658870

MK01
Mitogen-activated protein kinase 1

1

5

Small-scale

0.569

High

876983

PTC1
Protein patched homolog 1

2

0

Small-scale

0.559

High

876971

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.554

High

337078

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

2

0

High-throughput

0.547

High

618033

COF1
Cofilin-1

2

0

High-throughput

0.547

High

649074

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

Small-scale

0.536

High

876974

KPCZ
Protein kinase C zeta type

1

5

Small-scale

0.536

High

877000

MSTO1
Protein misato homolog 1

1

0

High-throughput

0.518

High

876986

HECD3
E3 ubiquitin-protein ligase HECTD3

1

5

Small-scale

0.512

High

373945

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

Small-scale

0.501

High

401710

JUN
Transcription factor Jun

1

4

Small-scale

0.501

High

414223

RB
Retinoblastoma-associated protein

1

5

Small-scale

0.501

High

486158

GRAB
Granzyme B

1

11

Small-scale

0.501

High

876993

HDAC7
Histone deacetylase 7

1

6

Small-scale

0.501

High

876999

RING2
E3 ubiquitin-protein ligase RING2

1

4

Small-scale

0.501

High

124385

HIP1
Huntingtin-interacting protein 1

1

3

Small-scale

0.479

High

311679

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

Small-scale

0.479

High

358992

CRYAB
Alpha-crystallin B chain

1

10

Small-scale

0.479

High

443428

VIME
Vimentin

1

5

Small-scale

0.479

High

572328

LEG3
Galectin-3

1

2

Small-scale

0.479

High

647527

MK03
Mitogen-activated protein kinase 3

1

5

Small-scale

0.479

High

749287

BRCA1
Breast cancer type 1 susceptibility protein

1

2

Small-scale

0.479

High

874729

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

876976

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

876978

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

3

High-throughput

0.479

High

876982

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

876992

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

877007

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

2

Small-scale

0.479

High

849084

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.460

High

876990

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

876991

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

70544

HGB1A
Putative high mobility group protein B1-like 1

1

3

High-throughput

0.445

High

876985

H90B2
Putative heat shock protein HSP 90-beta 2

1

3

High-throughput

0.445

High

876996

EFHD2
EF-hand domain-containing protein D2

1

1

Small-scale

0.437

High

877002

AMPB
Aminopeptidase B

2

0

High-throughput

0.298

High


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024