Protein: OTU6B
Deubiquitinase OTUD6B (EC 3.4.19.12) (DUBA-5) (OTU domain-containing protein 6B)

Gene: OTU6B, OTUD6B
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q8N6M0

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0006508 - proteolysis
GO:0008283 - cell population proliferation
GO:0016579 - protein deubiquitination
GO:0017148 - negative regulation of translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476050

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

8

Small-scale

0.687

High

1079544

NEDD8
NEDD8

1

2

Small-scale

0.647

High

1236136

OTUB1
Ubiquitin thioesterase OTUB1

2

1

Small-scale

0.641

High

1236143

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.618

High

1236140

BTBD1
BTB/POZ domain-containing protein 1

3

3

High-throughput

0.609

High

1072386

ELOB
Elongin-B

1

0

Small-scale

0.606

High

1168910

LN28B
Protein lin-28 homolog B

1

4

Small-scale

0.538

High

772059

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.537

High

582389

NUCL
Nucleolin

1

4

Small-scale

0.515

High

931278

YBOX1
Y-box-binding protein 1

1

4

Small-scale

0.515

High

1232172

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

4

High-throughput

0.515

High

1236134

SERB1
SERPINE1 mRNA-binding protein 1

1

2

Small-scale

0.515

High

806084

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.493

High

1236138

BTBD2
BTB/POZ domain-containing protein 2

1

2

High-throughput

0.489

High

72949

B4DPD5
Ubiquitin thioesterase

1

1

High-throughput

0.479

High

322880

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

Small-scale

0.470

High

814819

RL29
Large ribosomal subunit protein eL29

1

1

Small-scale

0.470

High

842572

RL14
Large ribosomal subunit protein eL14

1

1

Small-scale

0.470

High

907398

RS8
Small ribosomal subunit protein eS8

1

1

Small-scale

0.470

High

910882

RS18
Small ribosomal subunit protein uS13

1

1

Small-scale

0.470

High

913629

RL7A
Large ribosomal subunit protein eL8

1

1

Small-scale

0.470

High

920019

RS15
Small ribosomal subunit protein uS19

1

1

Small-scale

0.470

High

922627

RL10A
Large ribosomal subunit protein uL1

1

1

Small-scale

0.470

High

1086220

H31T
Histone H3.1t

1

2

High-throughput

0.470

High

1158082

DHX57
Putative ATP-dependent RNA helicase DHX57

1

4

Small-scale

0.470

High

1190212

DHX29
ATP-dependent RNA helicase DHX29

1

4

Small-scale

0.470

High

417010

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.458

High

1236142

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

1

Small-scale

0.457

High

483659

ST1A4
Sulfotransferase 1A4

1

1

High-throughput

0.437

High

497303

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.437

High

618665

IF4B
Eukaryotic translation initiation factor 4B

1

3

Small-scale

0.437

High

882429

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

892855

IF4A1
Eukaryotic initiation factor 4A-I

1

4

Small-scale

0.437

High

979949

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

2

Small-scale

0.437

High

1023202

FLII
Protein flightless-1 homolog

1

2

Small-scale

0.437

High

1170817

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

1236139

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.437

High

483648

ST1A3
Sulfotransferase 1A3

1

1

High-throughput

0.407

High

872977

GALC
Galactocerebrosidase

3

0

High-throughput

0.347

High

1236144

LIMC1
LIM and calponin homology domains-containing protein 1

3

0

High-throughput

0.347

High

623545

AKAP5
A-kinase anchor protein 5

1

0

High-throughput

0.279

Low

172880

CASC3
Protein CASC3

1

0

Small-scale

0.269

Low

400995

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.269

Low

574384

RL35A
Large ribosomal subunit protein eL33

1

0

Small-scale

0.269

Low

575106

RL7
Large ribosomal subunit protein uL30

1

0

Small-scale

0.269

Low

736584

RL4
Large ribosomal subunit protein uL4

1

0

Small-scale

0.269

Low

911444

RS11
Small ribosomal subunit protein uS17

1

0

Small-scale

0.269

Low

922865

RL32
Large ribosomal subunit protein eL32

1

0

Small-scale

0.269

Low

951650

RL19
Large ribosomal subunit protein eL19

1

0

Small-scale

0.269

Low

960539

PURA
Transcriptional activator protein Pur-alpha

1

0

Small-scale

0.269

Low

962213

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.269

Low

973137

RL6
Large ribosomal subunit protein eL6

1

0

Small-scale

0.269

Low

989852

RL18
Large ribosomal subunit protein eL18

1

0

Small-scale

0.269

Low

1092586

KNOP1
Lysine-rich nucleolar protein 1

1

0

Small-scale

0.269

Low

1199363

LYRIC
Protein LYRIC

1

0

High-throughput

0.269

Low

1220426

DJC10
DnaJ homolog subfamily C member 10

1

0

Small-scale

0.269

Low

1236135

H1X
Histone H1.10

1

0

Small-scale

0.269

Low

1236137

LTV1
Protein LTV1 homolog

1

0

Small-scale

0.269

Low

1236141

RPF2
Ribosome production factor 2 homolog

1

0

High-throughput

0.269

Low

1236145

RL36
Large ribosomal subunit protein eL36

1

0

Small-scale

0.269

Low

632328

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.249

Low

840984

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.249

Low

1064485

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024