Protein: TFE2
Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1)

Gene: TFE2, Tcf3
Organism: Mus musculus
Interactions: 116
UniProt ID: P15806

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

586085

ID2
DNA-binding protein inhibitor ID-2

5

20

Small-scale

0.907

High

586103

ASCL1
Achaete-scute homolog 1

4

20

Small-scale

0.888

High

586077

TFE2
Transcription factor E2-alpha

3

13

Small-scale

0.835

High

518499

MYOD1
Myoblast determination protein 1

3

12

Small-scale

0.829

High

586083

TWST1
Twist-related protein 1

2

20

Small-scale

0.821

High

586081

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

2

20

Small-scale

0.806

High

586155

ASCL3
Achaete-scute homolog 3

2

20

Small-scale

0.786

High

586084

ID3
DNA-binding protein inhibitor ID-3

2

20

Small-scale

0.783

High

586112

HAND2
Heart- and neural crest derivatives-expressed protein 2

2

20

Small-scale

0.783

High

586153

OLIG2
Oligodendrocyte transcription factor 2

2

20

Small-scale

0.776

High

586142

FER3L
Fer3-like protein

1

20

Small-scale

0.680

High

586149

BHE41
Class E basic helix-loop-helix protein 41

1

8

Small-scale

0.680

High

586156

OLIG1
Oligodendrocyte transcription factor 1

1

20

Small-scale

0.665

High

586096

PDLI4
PDZ and LIM domain protein 4

1

0

High-throughput

0.663

High

586143

CERS2
Ceramide synthase 2

1

0

High-throughput

0.663

High

586117

HAND1
Heart- and neural crest derivatives-expressed protein 1

1

20

Small-scale

0.653

High

586098

NGN2
Neurogenin-2

1

20

Small-scale

0.647

High

586105

ITF2
Transcription factor 4

1

13

Small-scale

0.647

High

586113

HTF4
Transcription factor 12

1

13

Small-scale

0.647

High

586094

UBC9
SUMO-conjugating enzyme UBC9

3

2

Small-scale

0.637

High

586082

RBTN2
Rhombotin-2

1

6

Small-scale

0.621

High

586106

TCF15
Transcription factor 15

1

20

Small-scale

0.621

High

586108

NDF1
Neurogenic differentiation factor 1

1

20

Small-scale

0.621

High

586119

Q6GTZ3
Idb1 protein

1

20

Small-scale

0.621

High

586087

ATOH1
Transcription factor Atoh1

1

20

Small-scale

0.618

High

586118

H2A2B
Histone H2A type 2-B

1

1

High-throughput

0.618

High

586128

H2A3
Histone H2A type 3

1

1

High-throughput

0.618

High

204842

TCF21
Transcription factor 21

1

20

High-throughput

0.590

High

586079

ID1
DNA-binding protein inhibitor ID-1

1

20

High-throughput

0.590

High

486804

CADH1
Cadherin-1

2

0

Small-scale

0.571

High

204311

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

1

High-throughput

0.541

High

236717

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

5

High-throughput

0.541

High

312471

NEMO
NF-kappa-B essential modulator

1

2

High-throughput

0.541

High

586086

BRCA1
Breast cancer type 1 susceptibility protein homolog

1

2

High-throughput

0.541

High

586088

FOXP1
Forkhead box protein P1

1

1

High-throughput

0.541

High

586100

C2TA
MHC class II transactivator

1

1

High-throughput

0.541

High

586125

JADE1
Protein Jade-1

1

7

High-throughput

0.541

High

586135

ERCC8
DNA excision repair protein ERCC-8

1

2

High-throughput

0.541

High

586147

PBX4
Pre-B-cell leukemia transcription factor 4

1

1

High-throughput

0.541

High

586154

RNF14
E3 ubiquitin-protein ligase RNF14

1

3

High-throughput

0.541

High

586161

TLE6
Transducin-like enhancer protein 6

1

6

High-throughput

0.541

High

586120

RGPA1
Ral GTPase-activating protein subunit alpha-1

1

0

Small-scale

0.529

High

98175

ZN277
Zinc finger protein 277

1

0

High-throughput

0.518

High

586097

GFI1
Zinc finger protein Gfi-1

1

0

High-throughput

0.518

High

586101

TAF1B
TATA box-binding protein-associated factor RNA polymerase I subunit B

1

0

High-throughput

0.518

High

586102

MEIS2
Homeobox protein Meis2

1

0

High-throughput

0.518

High

586127

RFX4
Transcription factor RFX4

1

0

High-throughput

0.518

High

586140

NS1BP
Influenza virus NS1A-binding protein homolog

1

0

High-throughput

0.518

High

586152

RAI14
Ankycorbin

1

0

High-throughput

0.518

High

586157

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.518

High

586158

PHF2
Lysine-specific demethylase PHF2

1

0

High-throughput

0.518

High

586163

PAPOB
Poly(A) polymerase beta

1

0

High-throughput

0.518

High

586165

T22D3
TSC22 domain family protein 3

1

0

High-throughput

0.518

High

586166

ZN292
Zinc finger protein 292

1

0

High-throughput

0.518

High

236948

MTG16
Protein CBFA2T3

1

9

Small-scale

0.501

High

586115

TRI27
Zinc finger protein RFP

1

2

Small-scale

0.501

High

586109

ELAV2
ELAV-like protein 2

1

1

High-throughput

0.494

High

586130

ZDH15
Palmitoyltransferase ZDHHC15

1

2

High-throughput

0.494

High

586133

SWAHC
Ankyrin repeat domain-containing protein SOWAHC

1

3

High-throughput

0.494

High

586150

ZDHC6
Palmitoyltransferase ZDHHC6

1

2

High-throughput

0.494

High

586123

MED16
Mediator of RNA polymerase II transcription subunit 16

1

1

High-throughput

0.481

High

148599

GATA2
Endothelial transcription factor GATA-2

1

2

Small-scale

0.479

High

267031

1433S
14-3-3 protein sigma

1

2

High-throughput

0.479

High

480958

NUCL
Nucleolin

1

1

High-throughput

0.479

High

535736

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

High-throughput

0.479

High

555795

PDCD6
Programmed cell death protein 6

1

1

High-throughput

0.479

High

568875

DNMT1
DNA

1

1

High-throughput

0.479

High

586080

FCER2
Low affinity immunoglobulin epsilon Fc receptor

1

1

Small-scale

0.479

High

586089

IF4A1
Eukaryotic initiation factor 4A-I

1

6

High-throughput

0.479

High

586092

H4
Histone H4

1

1

High-throughput

0.479

High

586095

1433T
14-3-3 protein theta

1

2

High-throughput

0.479

High

586099

LDB1
LIM domain-binding protein 1

1

2

Small-scale

0.479

High

586104

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

4

High-throughput

0.479

High

586107

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

586110

RBBP4
Histone-binding protein RBBP4

1

1

High-throughput

0.479

High

586111

RBBP7
Histone-binding protein RBBP7

1

1

High-throughput

0.479

High

586121

SRSF1
Serine/arginine-rich splicing factor 1

1

1

High-throughput

0.479

High

586122

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.479

High

586124

RIGI
Antiviral innate immune response receptor RIG-I

1

3

High-throughput

0.479

High

586132

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

2

High-throughput

0.479

High

586144

FOXP3
Forkhead box protein P3

1

1

Small-scale

0.479

High

586145

NONO
Non-POU domain-containing octamer-binding protein

1

3

High-throughput

0.479

High

586148

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

586160

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.479

High

586164

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

2

High-throughput

0.479

High

97704

E9PWG6
Non-SMC condensin I complex, subunit G

1

0

High-throughput

0.458

High

205651

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

0

High-throughput

0.458

High

508933

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

558920

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

569694

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.458

High

571090

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.458

High

586078

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

586090

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

586091

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.458

High

586093

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

586114

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

586131

Q8BQ46
TAF15 RNA polymerase II, TATA box binding protein

1

0

High-throughput

0.458

High

586134

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

High-throughput

0.458

High

586136

PAK2
Serine/threonine-protein kinase PAK 2

1

0

High-throughput

0.458

High

586137

CND1
Condensin complex subunit 1

1

0

High-throughput

0.458

High

586138

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.458

High

586141

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.458

High

586146

PARK7
Parkinson disease protein 7 homolog

1

0

High-throughput

0.458

High

586151

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

586159

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.458

High

586116

PHLA1
Pleckstrin homology-like domain family A member 1

1

0

High-throughput

0.438

High

528902

IF4A2
Eukaryotic initiation factor 4A-II

1

4

High-throughput

0.437

High

586126

DACT2
Dapper homolog 2

1

2

Small-scale

0.437

High

204515

PKD2
Polycystin-2

1

0

Small-scale

0.426

High

107945

G3UW74
Mediator of RNA polymerase II transcription subunit 16

1

1

High-throughput

0.417

High

549723

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

Small-scale

0.305

High

266721

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.249

Low

586129

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.249

Low

586139

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.249

Low

586162

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025