Protein: ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 3.6.4.12) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein)

Gene: ERCC2
Organism: Homo sapiens
Interactions: 75
UniProt ID: P18074

Gene Ontology (top 5):
GO:0000439 - transcription factor TFIIH core complex
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001666 - response to hypoxia
GO:0001701 - in utero embryonic development
GO:0003678 - DNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

574150

TF2H2
General transcription factor IIH subunit 2

7

4

Small-scale

0.961

High

574141

MAT1
CDK-activating kinase assembly factor MAT1

6

3

Small-scale

0.950

High

574130

TF2H1
General transcription factor IIH subunit 1

5

2

Small-scale

0.928

High

574138

CDK7
Cyclin-dependent kinase 7

11

3

Small-scale

0.758

High

574122

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

9

2

Small-scale

0.754

High

574157

T2H2L
General transcription factor IIH subunit 2-like protein

1

4

High-throughput

0.740

High

574170

MMS19
MMS19 nucleotide excision repair protein homolog

6

4

Small-scale

0.734

High

574140

CCNH
Cyclin-H

4

2

Small-scale

0.694

High

282816

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

4

5

Small-scale

0.689

High

574178

CIA2B
Cytosolic iron-sulfur assembly component 2B

4

5

Small-scale

0.689

High

574127

ERCC5
DNA excision repair protein ERCC-5

2

3

Small-scale

0.639

High

386058

P53
Cellular tumor antigen p53

2

1

Small-scale

0.619

High

574123

XPA
DNA repair protein complementing XP-A cells

1

1

Small-scale

0.618

High

574151

TF2H3
General transcription factor IIH subunit 3

2

2

Small-scale

0.595

High

574161

TF2H5
General transcription factor IIH subunit 5

2

0

Small-scale

0.592

High

368949

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

574155

UVSSA
UV-stimulated scaffold protein A

2

0

Small-scale

0.559

High

574121

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.547

High

125841

CDC7
Cell division cycle 7-related protein kinase

1

1

High-throughput

0.536

High

337905

EGFR
Epidermal growth factor receptor

1

0

Small-scale

0.513

High

574134

CETN2
Centrin-2

1

0

High-throughput

0.513

High

574139

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

0

High-throughput

0.513

High

574163

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

487114

ANDR
Androgen receptor

1

2

Small-scale

0.501

High

574128

T2EA
General transcription factor IIE subunit 1

1

1

Small-scale

0.501

High

574152

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

Small-scale

0.501

High

574167

TF2H4
General transcription factor IIH subunit 4

1

3

Small-scale

0.500

High

574136

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.493

High

574142

LMNB2
Lamin-B2

1

2

High-throughput

0.489

High

574177

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.480

High

73113

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

1

High-throughput

0.479

High

164349

TRI66
Tripartite motif-containing protein 66

1

1

High-throughput

0.479

High

226469

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

243900

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

360613

SPTA1
Spectrin alpha chain, erythrocytic 1

1

1

Small-scale

0.479

High

397767

ISG15
Ubiquitin-like protein ISG15

1

2

Small-scale

0.479

High

551903

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

574125

BRD2
Bromodomain-containing protein 2

1

4

High-throughput

0.479

High

574126

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

574129

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

574131

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

574133

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

574143

ERCC6
DNA excision repair protein ERCC-6

1

1

Small-scale

0.479

High

574144

HSF2
Heat shock factor protein 2

1

1

High-throughput

0.479

High

574145

RAD51
DNA repair protein RAD51 homolog 1

1

3

Small-scale

0.479

High

574147

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

574149

CUL3
Cullin-3

1

3

High-throughput

0.479

High

574153

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.479

High

574156

BRDT
Bromodomain testis-specific protein

1

4

High-throughput

0.479

High

574158

Q6PK50
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

574160

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

574162

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.479

High

574166

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

574168

Q96BE0
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

574171

Q9BPW0
Serine/threonine-protein phosphatase

1

1

High-throughput

0.479

High

574172

AASD1
Alanyl-tRNA editing protein Aarsd1

1

1

High-throughput

0.479

High

574174

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

574175

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.479

High

162390

XPO1
Exportin-1

1

0

High-throughput

0.458

High

345874

MYC
Myc proto-oncogene protein

1

0

Small-scale

0.458

High

384229

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

574124

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

574132

T2FA
General transcription factor IIF subunit 1

1

0

Small-scale

0.458

High

574137

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

574146

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.458

High

574148

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

574154

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

574159

MCAF1
Activating transcription factor 7-interacting protein 1

1

0

Small-scale

0.458

High

574165

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

574169

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

0

Small-scale

0.458

High

574173

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.458

High

574176

PIDD1
p53-induced death domain-containing protein 1

1

0

Small-scale

0.458

High

574135

SSRB
Translocon-associated protein subunit beta

1

0

High-throughput

0.279

Low

574164

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

100460

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024