Protein: TPM2
Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)

Gene: TPM2
Organism: Homo sapiens
Interactions: 165
UniProt ID: P07951

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005829 - cytosol
GO:0005862 - muscle thin filament tropomyosin
GO:0005884 - actin filament
GO:0006936 - muscle contraction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

464098

TPM1
Tropomyosin alpha-1 chain

10

17

Small-scale

0.973

High

447640

TPM3
Tropomyosin alpha-3 chain

8

17

High-throughput

0.961

High

464144

TPM4
Tropomyosin alpha-4 chain

6

17

High-throughput

0.937

High

464096

TPM2
Tropomyosin beta chain

5

17

Small-scale

0.916

High

464124

MYH9
Myosin-9

1

7

High-throughput

0.691

High

464125

ADDA
Alpha-adducin

1

4

High-throughput

0.691

High

464198

MYO19
Unconventional myosin-XIX

1

10

High-throughput

0.691

High

333281

SNAPN
SNARE-associated protein Snapin

3

4

High-throughput

0.667

High

464145

ACTS
Actin, alpha skeletal muscle

1

15

Small-scale

0.647

High

464217

PDLI7
PDZ and LIM domain protein 7

2

11

Small-scale

0.639

High

464137

ACTB
Actin, cytoplasmic 1

1

15

High-throughput

0.618

High

464138

ACTZ
Alpha-centractin

1

20

High-throughput

0.618

High

464191

MY18A
Unconventional myosin-XVIIIa

1

12

High-throughput

0.618

High

464216

MYO5C
Unconventional myosin-Vc

1

1

High-throughput

0.618

High

464128

MAGAA
Melanoma-associated antigen 10

2

3

High-throughput

0.611

High

464220

ABI2
Abl interactor 2

2

3

High-throughput

0.606

High

464104

CFTR
Cystic fibrosis transmembrane conductance regulator

2

3

High-throughput

0.601

High

464159

CD5R1
Cyclin-dependent kinase 5 activator 1

2

0

High-throughput

0.585

High

464215

ANLN
Anillin

2

4

High-throughput

0.584

High

464135

RAD
GTP-binding protein RAD

1

5

Small-scale

0.561

High

69755

ZN785
Zinc finger protein 785

2

1

High-throughput

0.553

High

464099

TFPT
TCF3 fusion partner

2

5

High-throughput

0.553

High

464173

ZN620
Zinc finger protein 620

2

1

High-throughput

0.553

High

464232

MOFA1
MORF4 family-associated protein 1

2

1

High-throughput

0.553

High

227156

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

17

High-throughput

0.536

High

279100

ULK1
Serine/threonine-protein kinase ULK1

1

9

High-throughput

0.536

High

316592

ST17B
Serine/threonine-protein kinase 17B

1

11

High-throughput

0.536

High

464110

FLNA
Filamin-A

1

6

High-throughput

0.536

High

464114

CDK2
Cyclin-dependent kinase 2

1

7

High-throughput

0.536

High

464119

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.536

High

464120

AKT2
RAC-beta serine/threonine-protein kinase

1

7

High-throughput

0.536

High

464121

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.536

High

464148

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.536

High

464168

LEG9C
Galectin-9C

1

8

High-throughput

0.536

High

464179

PIM3
Serine/threonine-protein kinase pim-3

1

11

High-throughput

0.536

High

464184

SYNPO
Synaptopodin

1

4

High-throughput

0.536

High

464202

AKAP9
A-kinase anchor protein 9

1

15

High-throughput

0.536

High

464207

RHBT2
Rho-related BTB domain-containing protein 2

1

10

High-throughput

0.536

High

464218

DISC1
Disrupted in schizophrenia 1 protein

1

5

High-throughput

0.536

High

464224

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

3

High-throughput

0.536

High

464226

HSPB8
Heat shock protein beta-8

1

6

High-throughput

0.536

High

464117

CALR
Calreticulin

1

7

High-throughput

0.515

High

464186

ATAD1
Outer mitochondrial transmembrane helix translocase

1

11

High-throughput

0.515

High

464199

PDLI5
PDZ and LIM domain protein 5

1

12

High-throughput

0.515

High

464230

NINL
Ninein-like protein

1

10

High-throughput

0.515

High

361067

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.515

High

464115

MK03
Mitogen-activated protein kinase 3

1

0

High-throughput

0.513

High

464156

SEPT2
Septin-2

1

0

High-throughput

0.513

High

464175

STOX1
Storkhead-box protein 1

1

0

High-throughput

0.513

High

464176

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

High-throughput

0.513

High

464185

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

0

High-throughput

0.513

High

464189

POF1B
Protein POF1B

1

0

High-throughput

0.513

High

464109

NEBU
Nebulin

1

3

Small-scale

0.501

High

464170

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

10

High-throughput

0.494

High

464164

CBPC2
Cytosolic carboxypeptidase 2

1

0

High-throughput

0.493

High

464206

CA043
Protein C1orf43

1

0

High-throughput

0.493

High

464111

H1T
Histone H1t

1

1

High-throughput

0.489

High

464122

PCGF2
Polycomb group RING finger protein 2

1

7

High-throughput

0.489

High

464147

FHR3
Complement factor H-related protein 3

1

2

High-throughput

0.489

High

464149

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.489

High

464161

CF184
Cilia- and flagella-associated protein 184

1

2

High-throughput

0.489

High

464181

FAM9C
Protein FAM9C

1

5

High-throughput

0.489

High

464182

SYCE1
Synaptonemal complex central element protein 1

1

3

High-throughput

0.489

High

464188

POC1B
POC1 centriolar protein homolog B

1

4

High-throughput

0.489

High

464205

WAC
WW domain-containing adapter protein with coiled-coil

1

2

High-throughput

0.489

High

179122

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

1

Small-scale

0.479

High

323112

TRI37
E3 ubiquitin-protein ligase TRIM37

1

15

High-throughput

0.479

High

365271

PGK1
Phosphoglycerate kinase 1

1

1

High-throughput

0.479

High

400143

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

425262

ISG15
Ubiquitin-like protein ISG15

1

8

High-throughput

0.479

High

464097

SP1
Transcription factor Sp1

1

8

Small-scale

0.479

High

464100

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.479

High

464102

EPB41
Protein 4.1

1

1

High-throughput

0.479

High

464112

CRCM
Colorectal mutant cancer protein

1

7

High-throughput

0.479

High

464118

PSB9
Proteasome subunit beta type-9

1

3

High-throughput

0.479

High

464129

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

464130

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

7

High-throughput

0.479

High

464131

CAZA2
F-actin-capping protein subunit alpha-2

1

5

High-throughput

0.479

High

464133

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

6

High-throughput

0.479

High

464136

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

464139

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.479

High

464150

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.479

High

464151

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

464153

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

16

High-throughput

0.479

High

464154

SCRB2
Lysosome membrane protein 2

1

4

High-throughput

0.479

High

464157

TNIP1
TNFAIP3-interacting protein 1

1

14

High-throughput

0.479

High

464158

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

464162

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

Small-scale

0.479

High

464165

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

464166

RN213
E3 ubiquitin-protein ligase RNF213

1

1

High-throughput

0.479

High

464167

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

464193

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

464197

AURKB
Aurora kinase B

1

9

High-throughput

0.479

High

464211

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

3

High-throughput

0.479

High

464213

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

464222

HDAC6
Protein deacetylase HDAC6

1

6

High-throughput

0.479

High

464223

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

464113

COF1
Cofilin-1

1

0

High-throughput

0.458

High

464140

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.458

High

464141

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

464142

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

464152

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

464180

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

0

Small-scale

0.458

High

464101

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

464143

GRB2
Growth factor receptor-bound protein 2

1

3

High-throughput

0.445

High

464200

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

5

High-throughput

0.445

High

136780

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

4

High-throughput

0.437

High

192429

INSI1
Insulin-induced gene 1 protein

1

5

High-throughput

0.437

High

269480

PLCH2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

1

2

High-throughput

0.437

High

330584

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.437

High

370958

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

377921

TNFA
Tumor necrosis factor

1

9

High-throughput

0.437

High

405695

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.437

High

417895

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.437

High

462828

LAMB1
Laminin subunit beta-1

1

14

High-throughput

0.437

High

464127

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.437

High

464132

CDK9
Cyclin-dependent kinase 9

1

9

High-throughput

0.437

High

464134

GEM
GTP-binding protein GEM

1

5

High-throughput

0.437

High

464160

MED1
Mediator of RNA polymerase II transcription subunit 1

1

5

High-throughput

0.437

High

464169

TET2
Methylcytosine dioxygenase TET2

1

2

Small-scale

0.437

High

464192

RYR2
Ryanodine receptor 2

1

3

High-throughput

0.437

High

464196

VMP1
Vacuole membrane protein 1

1

9

High-throughput

0.437

High

464208

DDX24
ATP-dependent RNA helicase DDX24

1

3

High-throughput

0.437

High

464209

SIK2
Serine/threonine-protein kinase SIK2

1

8

Small-scale

0.437

High

464212

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.437

High

464219

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

3

High-throughput

0.437

High

464221

RERE
Arginine-glutamic acid dipeptide repeats protein

1

5

High-throughput

0.437

High

464227

PRP19
Pre-mRNA-processing factor 19

1

4

Small-scale

0.437

High

49150

POTB3
POTE ankyrin domain family member B3

1

1

High-throughput

0.407

High

464203

KXDL1
KxDL motif-containing protein 1

1

7

High-throughput

0.407

High

464201

EBP2
Probable rRNA-processing protein EBP2

3

0

High-throughput

0.347

High

464174

S2548
Solute carrier family 25 member 48

2

0

High-throughput

0.328

High

464106

ZN250
Zinc finger protein 250

2

0

High-throughput

0.318

High

464183

CIART
Circadian-associated transcriptional repressor

2

0

High-throughput

0.318

High

464204

CF300
Cilia- and flagella-associated protein 300

2

0

High-throughput

0.318

High

334368

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

464155

MESD
LRP chaperone MESD

2

0

High-throughput

0.316

High

464225

ZN229
Zinc finger protein 229

2

0

High-throughput

0.316

High

64679

ASPDH
Aspartate dehydrogenase domain-containing protein

2

0

High-throughput

0.313

High

74203

CF97D
Sperm axonemal maintenance protein CFAP97D1

1

0

High-throughput

0.279

Low

221505

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.279

Low

464108

ZNF22
Zinc finger protein 22

1

0

High-throughput

0.279

Low

464171

TM205
Transmembrane protein 205

1

0

High-throughput

0.279

Low

464172

ZN704
Zinc finger protein 704

1

0

High-throughput

0.279

Low

464177

KANL1
KAT8 regulatory NSL complex subunit 1

1

0

High-throughput

0.279

Low

464178

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.279

Low

464190

SCG3
Secretogranin-3

1

0

High-throughput

0.279

Low

464194

MITOK
Mitochondrial potassium channel

1

0

High-throughput

0.279

Low

464210

RSH6A
Radial spoke head protein 6 homolog A

1

0

High-throughput

0.279

Low

464214

SHCAF
SIN3-HDAC complex-associated factor

1

0

High-throughput

0.279

Low

464229

IPKG
cAMP-dependent protein kinase inhibitor gamma

1

0

High-throughput

0.279

Low

464231

YIPF1
Protein YIPF1

1

0

High-throughput

0.279

Low

127599

HYAS3
Hyaluronan synthase 3

1

0

High-throughput

0.269

Low

464187

SEM6D
Semaphorin-6D

1

0

High-throughput

0.269

Low

464195

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.269

Low

464103

SKIL
Ski-like protein

1

0

High-throughput

0.265

Low

464105

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.249

Low

464107

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

464116

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

464123

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

464126

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

464146

EREP3
Protein ENTREP3

1

0

High-throughput

0.249

Low

464163

RC3H1
Roquin-1

1

0

High-throughput

0.249

Low

464228

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025