Protein: GSK3B
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)

Gene: GSK3B
Organism: Mus musculus
Interactions: 66
UniProt ID: Q9WV60

Gene Ontology (top 5):
GO:0000320 - re-entry into mitotic cell cycle
GO:0001558 - regulation of cell growth
GO:0001837 - epithelial to mesenchymal transition
GO:0002039 - p53 binding
GO:0004672 - protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

193199

AXIN1
Axin-1

7

7

Small-scale

0.957

High

1116171

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

3

10

High-throughput

0.861

High

682133

AKT1
RAC-alpha serine/threonine-protein kinase

3

20

Small-scale

0.845

High

973820

KPCZ
Protein kinase C zeta type

2

20

Small-scale

0.754

High

1376713

EPM2A
Laforin

1

1

Small-scale

0.747

High

1207923

Q8C3W2
Receptor tyrosine kinase-like orphan receptor 2

1

10

Small-scale

0.724

High

291902

AXIN2
Axin-2

1

7

Small-scale

0.713

High

292149

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.691

High

949427

TNIK
Traf2 and NCK-interacting protein kinase

1

18

High-throughput

0.691

High

1112666

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

3

High-throughput

0.691

High

1130142

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

18

Small-scale

0.691

High

970172

CTNB1
Catenin beta-1

4

10

Small-scale

0.683

High

139646

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

17

Small-scale

0.665

High

1141484

AKT2
RAC-beta serine/threonine-protein kinase

1

20

Small-scale

0.647

High

397223

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

19

Small-scale

0.618

High

901966

CD5R1
Cyclin-dependent kinase 5 activator 1

1

3

Small-scale

0.618

High

968964

SNAI1
Zinc finger protein SNAI1

1

4

Small-scale

0.618

High

1142510

ACVL1
Serine/threonine-protein kinase receptor R3

1

9

High-throughput

0.618

High

1143277

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

13

Small-scale

0.618

High

1208272

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

5

Small-scale

0.618

High

1351610

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4

1

19

Small-scale

0.618

High

498164

TAU
Microtubule-associated protein tau

2

11

Small-scale

0.595

High

834397

PSN1
Presenilin-1

2

1

Small-scale

0.595

High

1206939

Q8BNP7
Adenomatous polyposis coli N-terminal dimerisation domain-containing protein

2

5

Small-scale

0.595

High

1337477

PKHO1
Pleckstrin homology domain-containing family O member 1

1

0

Small-scale

0.586

High

356896

P53
Cellular tumor antigen p53

2

6

Small-scale

0.584

High

677656

CTND1
Catenin delta-1

1

20

Small-scale

0.561

High

100106

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

13

High-throughput

0.536

High

1142916

FXR1
RNA-binding protein FXR1

1

6

High-throughput

0.536

High

659538

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.513

High

1186431

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

0

High-throughput

0.513

High

102355

G3UXW9
G protein pathway suppressor 1

1

3

Small-scale

0.501

High

656019

CEBPB
CCAAT/enhancer-binding protein beta

1

10

Small-scale

0.501

High

956162

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

1

9

Small-scale

0.501

High

1141397

NF2L2
Nuclear factor erythroid 2-related factor 2

1

9

Small-scale

0.501

High

1265235

ARRB2
Beta-arrestin-2

1

6

Small-scale

0.501

High

1257404

CSN8
COP9 signalosome complex subunit 8

1

0

Small-scale

0.480

High

193597

CTND2
Catenin delta-2

1

16

Small-scale

0.479

High

291824

NEMO
NF-kappa-B essential modulator

1

12

Small-scale

0.479

High

546503

INGR1
Interferon gamma receptor 1

1

1

Small-scale

0.479

High

620864

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

786583

STAT3
Signal transducer and activator of transcription 3

1

5

Small-scale

0.479

High

869318

ATX1
Ataxin-1

1

3

High-throughput

0.479

High

897344

CSN2
COP9 signalosome complex subunit 2

1

3

Small-scale

0.479

High

906388

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

17

High-throughput

0.479

High

936292

TRAF6
TNF receptor-associated factor 6

1

9

Small-scale

0.479

High

1093550

TRI72
Tripartite motif-containing protein 72

1

6

Small-scale

0.479

High

1142529

APC
Adenomatous polyposis coli protein

1

18

Small-scale

0.479

High

1142628

E2F1
Transcription factor E2F1

1

10

Small-scale

0.479

High

1186508

DACT2
Dapper homolog 2

1

2

Small-scale

0.479

High

1194965

WDTC1
WD and tetratricopeptide repeats protein 1

1

9

High-throughput

0.479

High

1195023

DISC1
Disrupted in schizophrenia 1 homolog

1

1

Small-scale

0.479

High

1206890

DZIP1
Cilium assembly protein DZIP1

1

20

Small-scale

0.479

High

1207113

Q8BPK8
Agenet-like domain-containing protein

1

6

High-throughput

0.479

High

1207310

SMAD3
Mothers against decapentaplegic homolog 3

1

8

Small-scale

0.479

High

1246895

DACT1
Dapper homolog 1

1

2

Small-scale

0.479

High

1265647

EED
Polycomb protein EED

1

10

High-throughput

0.479

High

1307748

FOXP3
Forkhead box protein P3

1

2

High-throughput

0.479

High

1307798

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

7

Small-scale

0.479

High

1307858

TLR3
Toll-like receptor 3

1

3

Small-scale

0.479

High

1141775

SC6A4
Sodium-dependent serotonin transporter

1

0

High-throughput

0.458

High

1145391

ARF
Tumor suppressor ARF

1

0

Small-scale

0.458

High

1206757

TCAM2
TIR domain-containing adapter molecule 2

1

0

Small-scale

0.458

High

1112934

FBW1A
F-box/WD repeat-containing protein 1A

1

10

High-throughput

0.457

High

1307980

BHE41
Class E basic helix-loop-helix protein 41

1

3

High-throughput

0.457

High

729609

FMR1
Fragile X messenger ribonucleoprotein 1

1

6

High-throughput

0.445

High


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Last updated: 15 Jul 2024