Protein: TWF1
Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)

Gene: TWF1
Organism: Homo sapiens
Interactions: 140
UniProt ID: Q12792

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0003785 - actin monomer binding
GO:0005524 - ATP binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1016486

DREB
Drebrin

2

2

High-throughput

0.811

High

813418

CAPZB
F-actin-capping protein subunit beta

2

5

High-throughput

0.789

High

891728

ACTB
Actin, cytoplasmic 1

2

20

High-throughput

0.789

High

618064

COF1
Cofilin-1

1

10

High-throughput

0.691

High

785531

ACTY
Beta-centractin

1

20

High-throughput

0.691

High

896732

ARP3
Actin-related protein 3

1

20

High-throughput

0.691

High

896880

ARP2
Actin-related protein 2

1

20

High-throughput

0.691

High

929835

ACTG
Actin, cytoplasmic 2

1

20

High-throughput

0.691

High

986368

BTK
Tyrosine-protein kinase BTK

1

2

Small-scale

0.691

High

1016525

ARP10
Actin-related protein 10

1

20

High-throughput

0.691

High

932122

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.665

High

1016522

ANLN
Anillin

3

3

High-throughput

0.656

High

117679

MYO1C
Unconventional myosin-Ic

2

9

High-throughput

0.628

High

813004

CAZA2
F-actin-capping protein subunit alpha-2

2

6

High-throughput

0.628

High

862031

DAPK1
Death-associated protein kinase 1

2

5

High-throughput

0.628

High

1016529

LIMA1
LIM domain and actin-binding protein 1

2

4

High-throughput

0.628

High

1016521

TIGAR
Fructose-2,6-bisphosphatase TIGAR

2

1

High-throughput

0.621

High

338343

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.618

High

384735

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.618

High

897039

ACTZ
Alpha-centractin

1

20

High-throughput

0.618

High

931609

CSK2B
Casein kinase II subunit beta

2

0

High-throughput

0.580

High

261110

SH3L1
Adapter SH3BGRL

2

3

High-throughput

0.571

High

369489

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

596397

RASA1
Ras GTPase-activating protein 1

2

8

High-throughput

0.571

High

125877

CDC7
Cell division cycle 7-related protein kinase

1

5

High-throughput

0.536

High

168784

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

2

High-throughput

0.536

High

400056

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.536

High

598086

FLNA
Filamin-A

1

2

High-throughput

0.536

High

724797

MYH9
Myosin-9

1

4

High-throughput

0.536

High

768472

CAP2
Adenylyl cyclase-associated protein 2

1

10

High-throughput

0.536

High

809282

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

High-throughput

0.536

High

857109

CAZA1
F-actin-capping protein subunit alpha-1

1

6

High-throughput

0.536

High

906430

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

4

High-throughput

0.536

High

920948

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

3

High-throughput

0.536

High

921539

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.536

High

965184

CAP1
Adenylyl cyclase-associated protein 1

1

10

High-throughput

0.536

High

984569

CALD1
Caldesmon

1

11

High-throughput

0.536

High

1016477

SQSTM
Sequestosome-1

1

2

High-throughput

0.536

High

1016480

SCRB2
Lysosome membrane protein 2

1

2

High-throughput

0.536

High

1016482

DCTN1
Dynactin subunit 1

1

5

High-throughput

0.536

High

1016483

SRC8
Src substrate cortactin

1

3

High-throughput

0.536

High

1016485

AINX
Alpha-internexin

1

4

High-throughput

0.536

High

1016490

RHGBA
Rho GTPase-activating protein 11A

1

1

High-throughput

0.536

High

1016495

SYNPO
Synaptopodin

1

4

High-throughput

0.536

High

1016503

MY18A
Unconventional myosin-XVIIIa

1

8

High-throughput

0.536

High

1016508

MYO19
Unconventional myosin-XIX

1

7

High-throughput

0.536

High

1016524

TMOD3
Tropomodulin-3

1

2

High-throughput

0.536

High

1016531

COR1C
Coronin-1C

1

4

High-throughput

0.536

High

1016534

SCIN
Scinderin

1

1

High-throughput

0.536

High

431216

CATB
Cathepsin B

1

1

High-throughput

0.515

High

648740

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.515

High

364673

TRFL
Lactotransferrin

1

0

High-throughput

0.513

High

887455

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.513

High

946231

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.513

High

1016478

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.513

High

1016507

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

1016510

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1016518

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

0

High-throughput

0.513

High

1016528

DMBT1
Deleted in malignant brain tumors 1 protein

1

0

High-throughput

0.513

High

1016530

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.513

High

394615

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

1016497

FBX25
F-box only protein 25

1

3

Small-scale

0.501

High

364258

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.493

High

217023

PRIC3
Prickle planar cell polarity protein 3

1

1

High-throughput

0.489

High

1016498

BPIB1
BPI fold-containing family B member 1

1

1

High-throughput

0.489

High

1016500

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

2

High-throughput

0.489

High

1016519

MUC5B
Mucin-5B

1

4

High-throughput

0.489

High

1016520

BPIA1
BPI fold-containing family A member 1

1

1

High-throughput

0.489

High

128999

PLK4
Serine/threonine-protein kinase PLK4

1

1

Small-scale

0.479

High

227294

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

233407

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

298467

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

308657

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.479

High

346640

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

428164

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

443479

VIME
Vimentin

1

4

High-throughput

0.479

High

521896

CADH1
Cadherin-1

1

1

High-throughput

0.479

High

590875

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

808552

YAP1
Transcriptional coactivator YAP1

1

6

High-throughput

0.479

High

841684

CDK9
Cyclin-dependent kinase 9

1

5

High-throughput

0.479

High

870779

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

904498

1433G
14-3-3 protein gamma

1

5

High-throughput

0.479

High

914035

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

965651

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1016476

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

3

High-throughput

0.479

High

1016481

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

6

High-throughput

0.479

High

1016484

TNIP1
TNFAIP3-interacting protein 1

1

9

High-throughput

0.479

High

1016488

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.479

High

1016491

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1016492

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1016493

CUL9
Cullin-9

1

2

High-throughput

0.479

High

1016496

FBXW8
F-box/WD repeat-containing protein 8

1

3

High-throughput

0.479

High

1016499

STYX
Serine/threonine/tyrosine-interacting protein

1

5

High-throughput

0.479

High

1016502

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

1016504

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

1016512

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1016514

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.479

High

1016515

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

1016516

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

1016527

HDAC6
Histone deacetylase 6

1

1

High-throughput

0.479

High

790373

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.458

High

897713

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

1016505

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1016517

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1016523

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

496930

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.445

High

529042

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.445

High

717759

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

1016489

PKHA7
Pleckstrin homology domain-containing family A member 7

1

10

High-throughput

0.445

High

1016494

PALS1
Protein PALS1

1

2

High-throughput

0.445

High

200550

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

Small-scale

0.438

High

100707

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

525921

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.437

High

552589

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

651061

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

720329

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

884478

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.437

High

1016501

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

1016506

KCD12
BTB/POZ domain-containing protein KCTD12

1

2

Small-scale

0.437

High

1016509

RHOV
Rho-related GTP-binding protein RhoV

1

3

High-throughput

0.437

High

1016513

RHBT2
Rho-related BTB domain-containing protein 2

1

5

High-throughput

0.437

High

1016532

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

354056

IGHA1
Immunoglobulin heavy constant alpha 1

1

2

High-throughput

0.407

High

354153

IGHA2
Immunoglobulin heavy constant alpha 2

1

2

High-throughput

0.407

High

957255

MUC5A
Mucin-5AC

1

3

High-throughput

0.407

High

1016511

ZBT18
Zinc finger and BTB domain-containing protein 18

1

3

High-throughput

0.407

High

344291

AACT
Alpha-1-antichymotrypsin

1

0

High-throughput

0.279

Low

353116

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.279

Low

353409

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.279

Low

452752

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

901568

LYSC
Lysozyme C

1

0

High-throughput

0.279

Low

1016475

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.279

Low

1016479

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

1016526

GBG12

1

0

High-throughput

0.279

Low

177878

TMPS2
Transmembrane protease serine 2

1

0

High-throughput

0.249

Low

352596

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

637244

CATS
Cathepsin S

1

0

High-throughput

0.249

Low

1016533

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

353519

IGKC
Immunoglobulin kappa constant

1

0

High-throughput

0.232

Low

1016487

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024