Protein: PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)

Gene: PLCB1
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q9NQ66

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000785 - chromatin
GO:0004435 - phosphatidylinositol phospholipase C activity
GO:0004629 - phospholipase C activity
GO:0005096 - GTPase activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

350581

RASK
GTPase KRas

3

20

High-throughput

0.827

High

837649

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

2

3

Small-scale

0.825

High

153948

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

2

4

Small-scale

0.754

High

793157

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

2

High-throughput

0.667

High

1343179

PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

1

5

Small-scale

0.647

High

348942

RASN
GTPase NRas

1

20

High-throughput

0.618

High

349665

RASH
GTPase HRas

1

19

High-throughput

0.618

High

670488

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

3

Small-scale

0.618

High

895288

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.618

High

915998

RHOB
Rho-related GTP-binding protein RhoB

1

17

High-throughput

0.618

High

1070411

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.618

High

1182912

BT2A1
Butyrophilin subfamily 2 member A1

3

3

High-throughput

0.609

High

507255

LAMP1
Lysosome-associated membrane glycoprotein 1

2

2

High-throughput

0.584

High

1169029

DEFI8
Differentially expressed in FDCP 8 homolog

2

2

High-throughput

0.574

High

881307

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.573

High

1032634

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.573

High

1016874

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.549

High

1251545

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.549

High

963428

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

High-throughput

0.541

High

1343181

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

4

High-throughput

0.536

High

626663

ARBK1
Beta-adrenergic receptor kinase 1

1

1

Small-scale

0.501

High

971361

H11
Histone H1.1

1

0

High-throughput

0.493

High

1305277

PHB2
Prohibitin-2

1

0

High-throughput

0.493

High

1300588

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

4

Small-scale

0.481

High

131847

KRIT1
Krev interaction trapped protein 1

1

3

Small-scale

0.479

High

155455

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

377710

GCR
Glucocorticoid receptor

1

4

High-throughput

0.479

High

434024

LYN
Tyrosine-protein kinase Lyn

1

17

High-throughput

0.479

High

524589

LYL1
Protein lyl-1

1

2

High-throughput

0.479

High

527818

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

648900

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

742553

SYUA
Alpha-synuclein

1

2

Small-scale

0.479

High

831933

CEBPD
CCAAT/enhancer-binding protein delta

1

1

Small-scale

0.479

High

1171841

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1281148

KISSR
KiSS-1 receptor

1

5

Small-scale

0.479

High

1283074

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.479

High

1343180

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

545046

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

556982

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.458

High

913132

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1198186

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.458

High

1329198

GAN
Gigaxonin

1

0

High-throughput

0.458

High

240198

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

497635

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

1329605

ADNP
Activity-dependent neuroprotector homeobox protein

1

1

High-throughput

0.445

High

1336293

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

2

High-throughput

0.445

High

793484

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.437

High

378179

PRIO
Major prion protein

1

0

High-throughput

0.426

High

1047277

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

101204

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024