Protein: MP2K4
Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1)

Gene: MP2K4, Map2k4
Organism: Mus musculus
Interactions: 13
UniProt ID: P47809

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

867728

M3K1
Mitogen-activated protein kinase kinase kinase 1

3

19

Small-scale

0.827

High

867731

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

4

High-throughput

0.789

High

867733

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

19

Small-scale

0.665

High

867732

MK10
Mitogen-activated protein kinase 10

1

20

Small-scale

0.647

High

107137

F8VQ72
Mitogen-activated protein kinase kinase kinase 1

1

19

Small-scale

0.618

High

867729

KPCT
Protein kinase C theta type

1

18

Small-scale

0.618

High

867730

CDKL5
Cyclin-dependent kinase-like 5

1

20

High-throughput

0.618

High

205506

CFLAR
CASP8 and FADD-like apoptosis regulator

1

11

Small-scale

0.553

High

693157

TNR5
Tumor necrosis factor receptor superfamily member 5

1

5

Small-scale

0.515

High

867734

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.514

High

867736

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

20

Small-scale

0.457

High

867735

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

7

High-throughput

0.437

High

313248

NOE1
Noelin

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025