Protein: M3K7
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)

Gene: M3K7, Map3k7
Organism: Mus musculus
Interactions: 69
UniProt ID: Q62073

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0000287 - magnesium ion binding
GO:0001525 - angiogenesis
GO:0001649 - osteoblast differentiation
GO:0001841 - neural tube formation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1223469

TGFR2
TGF-beta receptor type-2

3

20

Small-scale

0.827

High

1223467

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

17

Small-scale

0.817

High

999843

TRAF6
TNF receptor-associated factor 6

10

18

Small-scale

0.750

High

1223486

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

7

8

Small-scale

0.739

High

312154

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

8

Small-scale

0.737

High

1223481

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

6

8

Small-scale

0.719

High

1223496

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

12

Small-scale

0.691

High

1201606

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

4

6

Small-scale

0.683

High

148446

BIRC3
Baculoviral IAP repeat-containing protein 3

1

8

Small-scale

0.665

High

548951

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

3

Small-scale

0.665

High

867733

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

19

Small-scale

0.665

High

1222278

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

6

Small-scale

0.665

High

1223468

BIRC2
Baculoviral IAP repeat-containing protein 2

1

5

Small-scale

0.665

High

1223470

IRAK1
Interleukin-1 receptor-associated kinase 1

1

20

Small-scale

0.665

High

1223492

TLR4
Toll-like receptor 4

1

18

Small-scale

0.665

High

1223498

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

Small-scale

0.665

High

1223493

HIPK2
Homeodomain-interacting protein kinase 2

1

20

Small-scale

0.646

High

1000228

SMAD1
Mothers against decapentaplegic homolog 1

2

8

Small-scale

0.624

High

869544

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

946715

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

15

Small-scale

0.618

High

999952

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

20

Small-scale

0.618

High

1204254

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

9

Small-scale

0.618

High

1222303

KSR1
Kinase suppressor of Ras 1

1

19

Small-scale

0.618

High

1223472

TGFR1
TGF-beta receptor type-1

1

17

Small-scale

0.618

High

1223476

VRK2
Serine/threonine-protein kinase VRK2

1

6

Small-scale

0.618

High

1223477

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

9

Small-scale

0.618

High

1223487

TLR3
Toll-like receptor 3

1

17

Small-scale

0.618

High

1223495

GSK3B
Glycogen synthase kinase-3 beta

1

13

Small-scale

0.618

High

509098

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

2

6

Small-scale

0.602

High

312501

NEMO
NF-kappa-B essential modulator

2

7

Small-scale

0.601

High

811908

TRAF2
TNF receptor-associated factor 2

2

19

Small-scale

0.601

High

1223497

BCL10
B-cell lymphoma/leukemia 10

2

1

Small-scale

0.601

High

669420

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

6

Small-scale

0.584

High

1021456

SMAD5
Mothers against decapentaplegic homolog 5

2

8

Small-scale

0.584

High

462121

HS90A
Heat shock protein HSP 90-alpha

1

14

Small-scale

0.575

High

1222270

CDC37
Hsp90 co-chaperone Cdc37

1

7

Small-scale

0.575

High

1221287

SKIL
Ski-like protein

1

1

Small-scale

0.573

High

948124

SASH1
SAM and SH3 domain-containing protein 1

1

2

Small-scale

0.553

High

1223482

CAR11
Caspase recruitment domain-containing protein 11

1

8

Small-scale

0.534

High

648057

MYD88
Myeloid differentiation primary response protein MyD88

1

4

Small-scale

0.515

High

957883

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

1

Small-scale

0.515

High

1180422

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

1

5

Small-scale

0.515

High

584837

TR30A
Tripartite motif-containing protein 30A

1

5

Small-scale

0.479

High

663105

GRIA2
Glutamate receptor 2

1

2

High-throughput

0.479

High

693163

TNR5
Tumor necrosis factor receptor superfamily member 5

1

5

Small-scale

0.479

High

728040

NOTC4
Neurogenic locus notch homolog protein 4

1

4

Small-scale

0.479

High

1021505

SMAD4
Mothers against decapentaplegic homolog 4

1

8

Small-scale

0.479

High

1022125

DAB2
Disabled homolog 2

1

6

Small-scale

0.479

High

1211414

TRI38
E3 ubiquitin-protein ligase TRIM38

1

6

Small-scale

0.479

High

1221306

PPP5
Serine/threonine-protein phosphatase 5

1

3

High-throughput

0.479

High

1223471

SMAD2
Mothers against decapentaplegic homolog 2

1

8

Small-scale

0.479

High

1223473

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1223478

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

1

4

Small-scale

0.479

High

1223479

SMAD3
Mothers against decapentaplegic homolog 3

1

8

Small-scale

0.479

High

1223483

CIKS
E3 ubiquitin ligase TRAF3IP2

1

1

Small-scale

0.479

High

1223485

MIB2
E3 ubiquitin-protein ligase MIB2

1

6

Small-scale

0.479

High

1223488

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

4

Small-scale

0.479

High

1223490

DAZP2
DAZ-associated protein 2

1

1

Small-scale

0.479

High

1223491

SMAD9
Mothers against decapentaplegic homolog 9

1

8

Small-scale

0.479

High

599244

IL7RA
Interleukin-7 receptor subunit alpha

1

0

Small-scale

0.458

High

1223475

TCAM2
TIR domain-containing adapter molecule 2

1

0

Small-scale

0.458

High

313258

NOE1
Noelin

1

2

Small-scale

0.437

High

1187337

Q3SXA6
TNFAIP3-interacting protein 3

1

2

Small-scale

0.437

High

1223474

TIPRL
TIP41-like protein

1

1

Small-scale

0.437

High

1223480

MT21E
Protein-lysine methyltransferase METTL21E

1

1

High-throughput

0.437

High

1223484

TRI29
Tripartite motif-containing protein 29

1

10

Small-scale

0.437

High

1223489

TBE
Tubulin epsilon chain

1

5

Small-scale

0.437

High

1223494

TM115
Transmembrane protein 115

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025