Protein: CDKL5
Cyclin-dependent kinase-like 5 (EC 2.7.11.22)

Gene: CDKL5
Organism: Mus musculus
Interactions: 88
UniProt ID: Q3UTQ8

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

547252

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

867730

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

20

High-throughput

0.618

High

1013574

TNIK
Traf2 and NCK-interacting protein kinase

1

15

High-throughput

0.618

High

1190861

CDKL5
Cyclin-dependent kinase-like 5

1

18

High-throughput

0.618

High

1190878

LRRC7
Leucine-rich repeat-containing protein 7

1

2

High-throughput

0.618

High

1190879

ERBIN
Erbin

1

4

High-throughput

0.618

High

1190882

CNKR2
Connector enhancer of kinase suppressor of ras 2

1

12

High-throughput

0.618

High

1190889

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

4

High-throughput

0.618

High

1190910

MINK1
Misshapen-like kinase 1

1

18

High-throughput

0.618

High

1190911

KC1E
Casein kinase I isoform epsilon

1

12

High-throughput

0.618

High

1190912

AFAD
Afadin

1

18

High-throughput

0.618

High

1190867

DLG4
Disks large homolog 4

2

13

High-throughput

0.584

High

503539

LRC4B
Leucine-rich repeat-containing protein 4B

1

2

High-throughput

0.553

High

1021270

G3BP2
Ras GTPase-activating protein-binding protein 2

1

4

High-throughput

0.553

High

1190870

PPR29
Protein phosphatase 1 regulatory subunit 29

1

3

High-throughput

0.553

High

1190884

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

10

High-throughput

0.553

High

1190886

SLIK5
SLIT and NTRK-like protein 5

1

2

High-throughput

0.553

High

1190895

ELFN1
Protein ELFN1

1

3

High-throughput

0.553

High

59348

LZTS3
Leucine zipper putative tumor suppressor 3

1

18

High-throughput

0.479

High

59856

RBGP1
Rab GTPase-activating protein 1

1

1

High-throughput

0.479

High

205676

CTND2
Catenin delta-2

1

14

High-throughput

0.479

High

607829

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

High-throughput

0.479

High

771470

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

8

High-throughput

0.479

High

811945

ZO1
Tight junction protein 1

1

14

High-throughput

0.479

High

947832

RHG39
Rho GTPase-activating protein 39

1

1

High-throughput

0.479

High

947855

YTHD1
YTH domain-containing family protein 1

1

3

High-throughput

0.479

High

968095

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

13

High-throughput

0.479

High

999785

DLG3
Disks large homolog 3

1

12

High-throughput

0.479

High

1036056

CTNB1
Catenin beta-1

1

12

High-throughput

0.479

High

1190097

DAB2P
Disabled homolog 2-interacting protein

1

6

High-throughput

0.479

High

1190866

CP131
Centrosomal protein of 131 kDa

1

20

High-throughput

0.479

High

1190868

SRBS1
Sorbin and SH3 domain-containing protein 1

1

5

High-throughput

0.479

High

1190871

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.479

High

1190874

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1190875

NEB2
Neurabin-2

1

20

High-throughput

0.479

High

1190883

MYOME
Myomegalin

1

19

High-throughput

0.479

High

1190893

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

7

High-throughput

0.479

High

1190897

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

3

High-throughput

0.479

High

1190901

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

8

High-throughput

0.479

High

1190902

UBAP2
Ubiquitin-associated protein 2

1

4

High-throughput

0.479

High

1190903

DLG2
Disks large homolog 2

1

13

High-throughput

0.479

High

1190906

RL14
Large ribosomal subunit protein eL14

1

2

High-throughput

0.479

High

1190913

PCM1
Pericentriolar material 1 protein

1

3

High-throughput

0.479

High

942255

SMO
Protein smoothened

1

0

Small-scale

0.458

High

1021880

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

1190863

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

1190892

Q8BNP7
Adenomatous polyposis coli protein

1

0

High-throughput

0.458

High

1190894

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

Small-scale

0.458

High

1190905

RTRAF
RNA transcription, translation and transport factor protein

1

0

High-throughput

0.458

High

64324

KCNB2
Potassium voltage-gated channel subfamily B member 2

1

4

High-throughput

0.437

High

73162

DLGP4
Disks large-associated protein 4

1

7

High-throughput

0.437

High

104525

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

6

High-throughput

0.437

High

267028

MOT2
Monocarboxylate transporter 2

1

2

High-throughput

0.437

High

531208

GSTM1
Glutathione S-transferase Mu 1

1

2

High-throughput

0.437

High

663092

GRIA2
Glutamate receptor 2

1

4

High-throughput

0.437

High

684049

GBRA2
Gamma-aminobutyric acid receptor subunit alpha-2

1

1

High-throughput

0.437

High

981220

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

1

High-throughput

0.437

High

1029193

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

8

High-throughput

0.437

High

1043830

KCNB1
Potassium voltage-gated channel subfamily B member 1

1

4

High-throughput

0.437

High

1179609

PSD3
PH and SEC7 domain-containing protein 3

1

3

High-throughput

0.437

High

1189495

PRC2C
Protein PRRC2C

1

6

High-throughput

0.437

High

1190844

ARHG9
Rho guanine nucleotide exchange factor 9

1

5

Small-scale

0.437

High

1190862

IQEC2
IQ motif and SEC7 domain-containing protein 2

1

3

High-throughput

0.437

High

1190864

SC6A4
Sodium-dependent serotonin transporter

1

3

High-throughput

0.437

High

1190873

DLGP3
Disks large-associated protein 3

1

7

High-throughput

0.437

High

1190877

ATX2L
Ataxin-2-like protein

1

5

High-throughput

0.437

High

1190880

AGRL3
Adhesion G protein-coupled receptor L3

1

2

High-throughput

0.437

High

1190881

UBP2L
Ubiquitin-associated protein 2-like

1

5

High-throughput

0.437

High

1190885

AGRB3
Adhesion G protein-coupled receptor B3

1

2

High-throughput

0.437

High

1190887

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

8

High-throughput

0.437

High

1190890

DLGP2
Disks large-associated protein 2

1

7

High-throughput

0.437

High

1190891

BAIP2
BAR/IMD domain-containing adapter protein 2

1

1

High-throughput

0.437

High

1190896

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

5

High-throughput

0.437

High

1190899

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

5

High-throughput

0.437

High

1190900

SH3K1
SH3 domain-containing kinase-binding protein 1

1

2

High-throughput

0.437

High

1190907

DLGP1
Disks large-associated protein 1

1

7

High-throughput

0.437

High

1190908

RBP2
E3 SUMO-protein ligase RanBP2

1

6

High-throughput

0.437

High

1190909

HIP1R
Huntingtin-interacting protein 1-related protein

1

20

High-throughput

0.437

High

59384

AJM1
Apical junction component 1 homolog

1

0

High-throughput

0.249

Low

866415

RP3A
Rabphilin-3A

1

0

High-throughput

0.249

Low

1190865

ASTN1
Astrotactin-1

1

0

High-throughput

0.249

Low

1190869

SANBR
SANT and BTB domain regulator of class switch recombination

1

0

High-throughput

0.249

Low

1190872

FBX41
F-box only protein 41

1

0

High-throughput

0.249

Low

1190876

PLPR4
Phospholipid phosphatase-related protein type 4

1

0

High-throughput

0.249

Low

1190888

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

0

High-throughput

0.249

Low

1190898

CACB4
Voltage-dependent L-type calcium channel subunit beta-4

1

0

High-throughput

0.249

Low

1190904

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025