HitPredict - High confidence protein-protein interactions

Protein: CFLAR
CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]

Gene: CFLAR
Organism: Mus musculus
Interactions: 9
UniProt ID: O35732

Gene Ontology (top 5):
GO:0004197 - cysteine-type endopeptidase activity
GO:0005737 - cytoplasm
GO:0006508 - proteolysis
GO:0006915 - apoptotic process
GO:0007519 - skeletal muscle tissue development

Download interactions: TXT MITAB-2.5

Interaction	Interactor	Experiments	Homologs	Category	Interaction Score	Confidence
205507	FADD FAS-associated death domain protein	2	17	Small-scale	0.776	High
205503	CASP8 Caspase-8	1	18	Small-scale	0.618	High
205509	MP2K7 Dual specificity mitogen-activated protein kinase kinase 7	1	9	Small-scale	0.618	High
205504	MP2K1 Dual specificity mitogen-activated protein kinase kinase 1	1	11	Small-scale	0.553	High
205506	MP2K4 Dual specificity mitogen-activated protein kinase kinase 4	1	11	Small-scale	0.553	High
205508	ITCH E3 ubiquitin-protein ligase Itchy	1	3	Small-scale	0.527	High
148626	HDAC1 Histone deacetylase 1	1	6	Small-scale	0.479	High
205502	HDAC3 Histone deacetylase 3	1	1	Small-scale	0.479	High
205505	TNFL6 Tumor necrosis factor ligand superfamily member 6	1	13	Small-scale	0.437	High

Service provided by Combinatics, Japan

Last updated: 11Aug2025