Protein: PIE1
Pharynx and intestine in excess protein 1 (Protein pie-1)

Gene: PIE1, pie-1
Organism: Caenorhabditis elegans
Interactions: 56
UniProt ID: Q94131

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001704 - formation of primary germ layer
GO:0001709 - cell fate determination
GO:0001933 - negative regulation of protein phosphorylation
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1171052

Q22805
C3H1-type domain-containing protein

2

1

High-throughput

0.815

High

110727

G5ECB9
C3H1-type domain-containing protein

2

3

High-throughput

0.775

High

1373898

Q9N368
RRM domain-containing protein

1

5

High-throughput

0.723

High

1373907

Q9XWV4
RRM domain-containing protein

1

3

High-throughput

0.723

High

1373892

PIE1
Pharynx and intestine in excess protein 1

1

3

High-throughput

0.656

High

196423

HDA1
Histone deacetylase 1

2

2

Small-scale

0.621

High

1373896

Q9GYQ9
CCR4-NOT transcription complex subunit 4

1

1

High-throughput

0.618

High

1170274

MEP1
MOG interacting and ectopic P-granules protein 1

1

0

Small-scale

0.568

High

1165669

HLH26
Helix-loop-helix protein 26

1

0

High-throughput

0.536

High

1170984

TFDP1
Transcription factor dpl-1

1

0

High-throughput

0.536

High

110295

LE418
Protein let-418

1

1

Small-scale

0.536

High

759424

ZIF1
Zinc finger-interacting factor 1

1

2

Small-scale

0.523

High

196466

O17761
Enoyl-CoA Hydratase

1

1

High-throughput

0.512

High

1373899

Q9N4P3
R3H domain-containing protein

1

2

High-throughput

0.512

High

1164764

PHA4
Defective pharyngeal development protein 4

1

1

High-throughput

0.508

High

1166221

UN130
Forkhead box protein unc-130

1

1

High-throughput

0.508

High

1018959

HRPK1
Heterogeneous nuclear ribonucleoprotein K homolog

1

7

High-throughput

0.494

High

196852

MAB3
Protein male abnormal 3

1

0

High-throughput

0.486

High

1165916

Q18241
Helicase ARIP4

1

0

High-throughput

0.486

High

1373897

Q9N360
C2H2-type domain-containing protein

1

0

High-throughput

0.486

High

1373906

Q9XVN4
Homeobox domain-containing protein

1

0

High-throughput

0.486

High

145717

O02174
C3H1-type domain-containing protein

1

1

High-throughput

0.481

High

1372510

Q93156
BED-type domain-containing protein

1

1

High-throughput

0.481

High

195654

O16720
Protein argonaute-1

1

4

High-throughput

0.479

High

195944

GLD2
Poly(A) RNA polymerase gld-2

1

1

High-throughput

0.479

High

759001

PLK1
Serine/threonine-protein kinase plk-1

1

3

High-throughput

0.479

High

1165079

Q17796
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

High-throughput

0.479

High

1169711

HDA6
Histone deacetylase 6

1

4

High-throughput

0.479

High

1373900

Q9TXM1
Uncharacterized protein

1

2

High-throughput

0.479

High

1166032

Q18477
Histone deacetylase 11

1

4

High-throughput

0.464

High

759269

CCNT1
Cyclin-T1.1

1

0

Small-scale

0.458

High

1171264

MRE11
Double-strand break repair protein mre-11

1

0

High-throughput

0.458

High

1373894

GLD3
Defective in germ line development protein 3

1

0

High-throughput

0.458

High

115538

H2KZI6
C3H1-type domain-containing protein

1

1

High-throughput

0.457

High

1373902

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.457

High

1373905

Q9U3S8
BED-type domain-containing protein

1

1

High-throughput

0.457

High

115005

H2KY58
ALG-1

1

1

High-throughput

0.437

High

1165019

Q17740
ALG-1 INteracting protein

1

1

High-throughput

0.437

High

1170493

Q21854
BTB domain-containing protein

1

1

High-throughput

0.437

High

1373903

Q9U2X1
Pept_C1 domain-containing protein

2

0

High-throughput

0.329

High

145291

O01900
TFIIS central domain-containing protein

1

0

High-throughput

0.292

High

1166544

Q19279
Nematode Specific Peptide family, group B

1

0

High-throughput

0.292

High

1373893

Q95YD9
LITAF domain-containing protein

1

0

High-throughput

0.292

High

114015

G5EGM7
Patterned Expression Site

1

0

High-throughput

0.257

Low

112268

G5EE42
Protein NATD1

1

0

High-throughput

0.249

Low

145883

O02297
SKN-1 Dependent Zygotic transcript

1

0

High-throughput

0.249

Low

233640

O44954
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.249

Low

233652

O44962
DUF148 domain-containing protein

1

0

High-throughput

0.249

Low

1169622

Q20062
Isochorismatase domain-containing protein 1

1

0

High-throughput

0.249

Low

1180995

Q304D5
Thioredoxin domain-containing protein

1

0

High-throughput

0.249

Low

1372630

Q93716
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.249

Low

1373895

Q9GPA0
UDP-Glucose Glycoprotein glucosylTransferase

1

0

High-throughput

0.249

Low

1373901

NSUN1
26S rRNA

1

0

High-throughput

0.249

Low

1373904

Q9U334
Septin

1

0

High-throughput

0.249

Low

1373908

Q9XXJ1
hydroxyacylglutathione hydrolase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025