Protein: TLK1
Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1)

Gene: TLK1
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q9UKI8

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006325 - chromatin organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1199548

TLK2
Serine/threonine-protein kinase tousled-like 2

7

17

Small-scale

0.963

High

1356453

TLK1
Serine/threonine-protein kinase tousled-like 1

4

17

Small-scale

0.902

High

1162545

ZN773
Zinc finger protein 773

2

1

High-throughput

0.783

High

1236860

ZN655
Zinc finger protein 655

2

1

High-throughput

0.783

High

1356455

ASF1A
Histone chaperone ASF1A

7

7

Small-scale

0.750

High

160843

AURKA
Aurora kinase A

1

18

Small-scale

0.724

High

1291323

DYL2
Dynein light chain 2, cytoplasmic

5

4

High-throughput

0.717

High

928515

DYL1
Dynein light chain 1, cytoplasmic

4

4

High-throughput

0.704

High

1346791

ASF1B
Histone chaperone ASF1B

4

7

Small-scale

0.701

High

485195

ZSC22
Zinc finger and SCAN domain-containing protein 22

2

1

High-throughput

0.700

High

1108456

ZN829
Zinc finger protein 829

2

1

High-throughput

0.700

High

647708

MK03
Mitogen-activated protein kinase 3

1

20

High-throughput

0.691

High

986053

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

4

High-throughput

0.667

High

154265

CHK1
Serine/threonine-protein kinase Chk1

1

10

Small-scale

0.647

High

246294

NBN
Nibrin

1

1

Small-scale

0.647

High

1344289

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

2

4

High-throughput

0.628

High

932442

ACTC
Actin, alpha cardiac muscle 1

1

6

High-throughput

0.618

High

1292284

AURKB
Aurora kinase B

1

16

High-throughput

0.618

High

1299592

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

2

Small-scale

0.618

High

1082503

HLF
Hepatic leukemia factor

2

6

High-throughput

0.612

High

641599

PAX6
Paired box protein Pax-6

2

7

High-throughput

0.606

High

839843

LHX2
LIM/homeobox protein Lhx2

2

3

High-throughput

0.606

High

1016898

TFCP2
Alpha-globin transcription factor CP2

2

1

High-throughput

0.606

High

1161665

GASP3
G protein-coupled receptor associated sorting protein 3

2

2

High-throughput

0.606

High

1183784

DPPA4
Developmental pluripotency-associated protein 4

2

0

High-throughput

0.580

High

1222234

YAF2
YY1-associated factor 2

2

0

High-throughput

0.580

High

1285590

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

2

0

High-throughput

0.580

High

1139305

SPAT1
Spermatogenesis-associated protein 1

2

1

High-throughput

0.574

High

1349899

LUZP4
Leucine zipper protein 4

1

0

High-throughput

0.549

High

910142

1433E
14-3-3 protein epsilon

1

18

High-throughput

0.541

High

1305395

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.537

High

727200

DDIT3
DNA damage-inducible transcript 3 protein

1

1

High-throughput

0.536

High

867902

HIRA
Protein HIRA

1

5

High-throughput

0.536

High

906626

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

20

High-throughput

0.536

High

1294658

ABHEB
Putative protein-lysine deacylase ABHD14B

1

1

High-throughput

0.536

High

362113

MBP
Myelin basic protein

1

1

Small-scale

0.501

High

1072732

UBE3C
Ubiquitin-protein ligase E3C

1

19

High-throughput

0.494

High

533636

TNNT1
Troponin T, slow skeletal muscle

1

1

High-throughput

0.489

High

669061

PML
Protein PML

1

7

High-throughput

0.479

High

831782

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.479

High

935357

H31
Histone H3.1

1

10

High-throughput

0.479

High

1019170

TP53B
TP53-binding protein 1

1

4

High-throughput

0.479

High

1035291

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

5

High-throughput

0.479

High

1043299

CUL4A
Cullin-4A

1

10

High-throughput

0.479

High

1288374

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

7

High-throughput

0.479

High

1354805

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1138402

Q5VU62
TPM3 protein

1

8

High-throughput

0.470

High

897660

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

1314421

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

989175

FMR1
Fragile X messenger ribonucleoprotein 1

1

5

High-throughput

0.457

High

1354500

ZO2
Tight junction protein ZO-2

1

7

High-throughput

0.445

High

1356454

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.445

High

419077

TPM3
Tropomyosin alpha-3 chain

1

8

High-throughput

0.439

High

1255336

MIPT3
TRAF3-interacting protein 1

1

1

High-throughput

0.417

High

118095

SNP23
Synaptosomal-associated protein 23

1

0

Small-scale

0.391

High

1237284

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.316

High

1350075

RELCH
RAB11-binding protein RELCH

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024