Protein: ACSL4
Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4)

Gene: ACSL4
Organism: Homo sapiens
Interactions: 139
UniProt ID: O60488

Gene Ontology (top 5):
GO:0001676 - long-chain fatty acid metabolic process
GO:0004467 - long-chain fatty acid-CoA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005741 - mitochondrial outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

234754

ACSL3
Fatty acid CoA ligase Acsl3

2

4

High-throughput

0.789

High

234778

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

3

2

High-throughput

0.667

High

225993

PRKN
E3 ubiquitin-protein ligase parkin

3

7

Small-scale

0.640

High

234832

EID3
EP300-interacting inhibitor of differentiation 3

3

0

High-throughput

0.638

High

234858

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

2

4

High-throughput

0.628

High

234748

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

4

Small-scale

0.618

High

234768

NEP
Neprilysin

2

0

High-throughput

0.602

High

234795

S15A1
Solute carrier family 15 member 1

2

0

High-throughput

0.602

High

234821

S39AC
Zinc transporter ZIP12

2

0

High-throughput

0.602

High

234774

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.601

High

234802

VA0D1
V-type proton ATPase subunit d 1

2

0

High-throughput

0.585

High

234762

GCR
Glucocorticoid receptor

2

6

Small-scale

0.584

High

234780

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

3

Small-scale

0.584

High

234807

RHOB
Rho-related GTP-binding protein RhoB

2

11

High-throughput

0.584

High

234766

KPCB
Protein kinase C beta type

1

1

Small-scale

0.561

High

234834

MTMRE
Myotubularin-related protein 14

2

1

High-throughput

0.558

High

234853

HTAI2
Oxidoreductase HTATIP2

1

0

Small-scale

0.549

High

234752

SH3L1
Adapter SH3BGRL

2

0

High-throughput

0.547

High

153047

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

1

High-throughput

0.536

High

171897

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.536

High

173254

S22A2
Solute carrier family 22 member 2

1

2

High-throughput

0.536

High

234760

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

4

High-throughput

0.536

High

234767

ASGR2
Asialoglycoprotein receptor 2

1

2

High-throughput

0.536

High

234769

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.536

High

234773

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

2

High-throughput

0.536

High

234781

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

5

High-throughput

0.536

High

234785

DHI1
11-beta-hydroxysteroid dehydrogenase 1

1

1

High-throughput

0.536

High

234792

OPRX
Nociceptin receptor

1

2

High-throughput

0.536

High

234793

EAA3
Excitatory amino acid transporter 3

1

4

High-throughput

0.536

High

234796

GPR12
G-protein coupled receptor 12

1

1

High-throughput

0.536

High

234819

AAAT
Neutral amino acid transporter B(0)

1

4

High-throughput

0.536

High

234828

T150A
Transmembrane protein 150A

1

1

High-throughput

0.536

High

234831

SPART
Spartin

1

2

Small-scale

0.536

High

234836

COQ8A
Atypical kinase COQ8A, mitochondrial

1

1

High-throughput

0.536

High

234845

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

3

High-throughput

0.536

High

234857

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

1

1

High-throughput

0.536

High

234863

SG196
Protein O-mannose kinase

1

1

High-throughput

0.536

High

234835

TOIP2
Torsin-1A-interacting protein 2

2

0

High-throughput

0.528

High

234873

DSE
Dermatan-sulfate epimerase

1

0

High-throughput

0.518

High

234844

H2B1H
Histone H2B type 1-H

1

2

High-throughput

0.515

High

118935

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.513

High

179134

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

234776

NAGAB
Alpha-N-acetylgalactosaminidase

1

0

High-throughput

0.513

High

234787

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.513

High

234794

ABCG1
ATP-binding cassette sub-family G member 1

1

0

High-throughput

0.513

High

234822

TJAP1
Tight junction-associated protein 1

1

0

High-throughput

0.513

High

234837

ACTT2
Actin-related protein T2

1

0

High-throughput

0.513

High

234840

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.513

High

234847

ORAI1
Calcium release-activated calcium channel protein 1

1

0

High-throughput

0.513

High

234851

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.513

High

234854

TGT
Queuine tRNA-ribosyltransferase catalytic subunit 1

1

0

High-throughput

0.513

High

234859

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

234875

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

234765

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

234782

1433T
14-3-3 protein theta

1

1

High-throughput

0.501

High

234820

NTRK3
NT-3 growth factor receptor

1

10

High-throughput

0.500

High

234784

DMB
HLA class II histocompatibility antigen, DM beta chain

1

3

High-throughput

0.489

High

234799

FOXA3
Hepatocyte nuclear factor 3-gamma

1

5

High-throughput

0.489

High

234800

FOXL2
Forkhead box protein L2

1

5

High-throughput

0.489

High

234806

LCN6
Epididymal-specific lipocalin-6

1

1

High-throughput

0.489

High

234826

FOXI2
Forkhead box protein I2

1

5

High-throughput

0.489

High

234830

S22A9
Organic anion transporter 7

1

2

High-throughput

0.489

High

234842

FOXJ1
Forkhead box protein J1

1

5

High-throughput

0.489

High

234843

TF3B
Transcription factor IIIB 90 kDa subunit

1

4

High-throughput

0.489

High

234848

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

234856

FOXQ1
Forkhead box protein Q1

1

6

High-throughput

0.489

High

234872

RSP14
Radial spoke head 14 homolog

1

1

High-throughput

0.489

High

148188

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

202000

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

1

High-throughput

0.479

High

234749

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.479

High

234753

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.479

High

234755

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

234756

RASN
GTPase NRas

1

7

High-throughput

0.479

High

234757

RASH
GTPase HRas

1

5

High-throughput

0.479

High

234758

RASK
GTPase KRas

1

7

High-throughput

0.479

High

234761

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

234764

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

234771

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

234772

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

234777

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

234779

RAB5A
Ras-related protein Rab-5A

1

3

Small-scale

0.479

High

234786

PML
Protein PML

1

1

High-throughput

0.479

High

234797

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.479

High

234801

CDC42
Cell division control protein 42 homolog

1

8

High-throughput

0.479

High

234803

RHOA
Transforming protein RhoA

1

11

High-throughput

0.479

High

234808

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

234809

TYB10
Thymosin beta-10

1

1

High-throughput

0.479

High

234810

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

Small-scale

0.479

High

234813

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.479

High

234814

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.479

High

234818

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

234825

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

234827

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

234829

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

5

Small-scale

0.479

High

234841

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

234849

RN185
E3 ubiquitin-protein ligase RNF185

1

1

High-throughput

0.479

High

234850

NEB2
Neurabin-2

1

1

High-throughput

0.479

High

234860

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

234862

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

234865

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.479

High

234870

HDAC6
Histone deacetylase 6

1

1

High-throughput

0.479

High

234871

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

155218

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

234763

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

234788

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

234790

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

234791

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

234798

SMCA2
Probable global transcription activator SNF2L2

1

0

High-throughput

0.458

High

234805

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

High-throughput

0.458

High

234812

VIGLN
Vigilin

1

0

High-throughput

0.458

High

234846

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.458

High

234864

ANTR1
Anthrax toxin receptor 1

1

0

Small-scale

0.458

High

234867

MTCH1
Mitochondrial carrier homolog 1

1

0

High-throughput

0.458

High

234868

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.458

High

234874

SHLB1
Endophilin-B1

1

0

Small-scale

0.458

High

234770

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

234823

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

130363

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.437

High

234751

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

2

High-throughput

0.437

High

234775

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

234783

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

234789

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

234804

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

234839

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

2

High-throughput

0.437

High

234855

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

1

High-throughput

0.437

High

234866

ANLN
Anillin

1

1

High-throughput

0.437

High

234750

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

234759

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.426

High

234816

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

234833

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

234869

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.426

High

234838

TB22A
TBC1 domain family member 22A

3

0

High-throughput

0.347

High

234861

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

2

0

High-throughput

0.305

High

234811

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.279

Low

234815

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

234817

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.279

Low

234824

MIC10
MICOS complex subunit MIC10

1

0

Small-scale

0.249

Low

234852

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024