Protein: LTK
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)

Gene: LTK
Organism: Homo sapiens
Interactions: 147
UniProt ID: P29376

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

655225

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

20

Small-scale

0.861

High

666003

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.789

High

666572

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.789

High

580940

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

20

Small-scale

0.754

High

666663

ALK
ALK tyrosine kinase receptor

2

19

Small-scale

0.737

High

337989

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.724

High

665146

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.715

High

666582

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.665

High

573585

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

Small-scale

0.648

High

666637

LMTK3
Serine/threonine-protein kinase LMTK3

1

19

High-throughput

0.646

High

129213

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.618

High

118696

AIP
AH receptor-interacting protein

1

19

High-throughput

0.618

High

145974

SH2B2
SH2B adapter protein 2

1

20

High-throughput

0.618

High

373738

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.618

High

640049

MOES
Moesin

1

20

High-throughput

0.618

High

666578

DYST
Dystonin

1

20

High-throughput

0.618

High

666588

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

High-throughput

0.618

High

666590

LIPA1
Liprin-alpha-1

1

12

High-throughput

0.618

High

666592

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.618

High

666616

PKHM3
Pleckstrin homology domain-containing family M member 3

1

1

High-throughput

0.618

High

666638

ERBIN
Erbin

1

20

High-throughput

0.618

High

666614

ALKL1
ALK and LTK ligand 1

1

3

Small-scale

0.569

High

666580

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.553

High

666615

MPRIP
Myosin phosphatase Rho-interacting protein

1

20

High-throughput

0.553

High

666628

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

20

High-throughput

0.553

High

508835

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

666560

DHB4
Peroxisomal multifunctional enzyme type 2

1

5

High-throughput

0.536

High

666569

ABCE1
ATP-binding cassette sub-family E member 1

1

9

High-throughput

0.536

High

666579

NOTC2
Neurogenic locus notch homolog protein 2

1

20

High-throughput

0.536

High

666594

DX39B
Spliceosome RNA helicase DDX39B

1

9

High-throughput

0.536

High

666595

DSG2
Desmoglein-2

1

20

High-throughput

0.536

High

666613

ALKL2
ALK and LTK ligand 2

1

3

High-throughput

0.536

High

666635

DDX27
Probable ATP-dependent RNA helicase DDX27

1

15

High-throughput

0.536

High

666651

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.536

High

666654

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.536

High

610248

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.501

High

322223

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.500

High

390725

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

5

High-throughput

0.500

High

455122

PARP1
Poly [ADP-ribose] polymerase 1

1

9

High-throughput

0.500

High

666558

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

5

High-throughput

0.500

High

666567

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

9

High-throughput

0.500

High

666568

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

9

High-throughput

0.500

High

666583

DHX9
ATP-dependent RNA helicase A

1

13

High-throughput

0.500

High

666634

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

20

High-throughput

0.500

High

666607

DUS6
Dual specificity protein phosphatase 6

1

20

High-throughput

0.494

High

666622

MTMRE
Myotubularin-related protein 14

1

3

High-throughput

0.494

High

260765

H2AY
Core histone macro-H2A.1

1

5

High-throughput

0.489

High

588841

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

7

High-throughput

0.489

High

666561

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

14

High-throughput

0.489

High

666570

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.489

High

666571

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

2

High-throughput

0.489

High

666585

SSRP1
FACT complex subunit SSRP1

1

10

High-throughput

0.489

High

666586

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

11

High-throughput

0.489

High

666591

SRSF9
Serine/arginine-rich splicing factor 9

1

14

High-throughput

0.489

High

666596

SAFB2
Scaffold attachment factor B2

1

16

High-throughput

0.489

High

666602

IPYR
Inorganic pyrophosphatase

1

2

High-throughput

0.489

High

666604

SAFB1
Scaffold attachment factor B1

1

15

High-throughput

0.489

High

666606

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.489

High

666611

ZN326
DBIRD complex subunit ZNF326

1

4

High-throughput

0.489

High

666636

RBM14
RNA-binding protein 14

1

15

High-throughput

0.489

High

666642

RM01
Large ribosomal subunit protein uL1m

1

1

High-throughput

0.489

High

666650

SFXN1
Sideroflexin-1

1

4

High-throughput

0.489

High

666668

SP16H
FACT complex subunit SPT16

1

6

High-throughput

0.489

High

153877

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

20

High-throughput

0.479

High

159901

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.479

High

225537

PCDH7
Protocadherin-7

1

10

High-throughput

0.479

High

311483

SMC2
Structural maintenance of chromosomes protein 2

1

12

High-throughput

0.479

High

398647

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

9

High-throughput

0.479

High

451845

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

5

High-throughput

0.479

High

631353

BRD2
Bromodomain-containing protein 2

1

5

High-throughput

0.479

High

654092

CALX
Calnexin

1

19

High-throughput

0.479

High

666556

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.479

High

666559

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

6

High-throughput

0.479

High

666564

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

666565

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

666566

RAB8A
Ras-related protein Rab-8A

1

15

High-throughput

0.479

High

666577

DSC2
Desmocollin-2

1

20

High-throughput

0.479

High

666581

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.479

High

666584

GOGA3
Golgin subfamily A member 3

1

19

High-throughput

0.479

High

666597

FLOT2
Flotillin-2

1

13

High-throughput

0.479

High

666598

GOGB1
Golgin subfamily B member 1

1

20

High-throughput

0.479

High

666599

SYK
Lysine--tRNA ligase

1

7

High-throughput

0.479

High

666601

KIF14
Kinesin-like protein KIF14

1

14

High-throughput

0.479

High

666608

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.479

High

666609

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

10

High-throughput

0.479

High

666610

GRDN
Girdin

1

20

High-throughput

0.479

High

666612

F1711
Protein FAM171A1

1

20

High-throughput

0.479

High

666618

LSR
Lipolysis-stimulated lipoprotein receptor

1

5

High-throughput

0.479

High

666623

NBEA
Neurobeachin

1

18

High-throughput

0.479

High

666624

DDX54
ATP-dependent RNA helicase DDX54

1

15

High-throughput

0.479

High

666625

DLG5
Disks large homolog 5

1

20

High-throughput

0.479

High

666626

FRS2
Fibroblast growth factor receptor substrate 2

1

20

High-throughput

0.479

High

666627

PDC6I
Programmed cell death 6-interacting protein

1

13

High-throughput

0.479

High

666631

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

8

High-throughput

0.479

High

666640

PKP2
Plakophilin-2

1

20

High-throughput

0.479

High

666647

GCP60
Golgi resident protein GCP60

1

15

High-throughput

0.479

High

666649

GORS2
Golgi reassembly-stacking protein 2

1

13

High-throughput

0.479

High

666652

WDR6
tRNA

1

20

High-throughput

0.479

High

666658

DJB11
DnaJ homolog subfamily B member 11

1

20

High-throughput

0.479

High

666660

ERRFI
ERBB receptor feedback inhibitor 1

1

15

Small-scale

0.479

High

666662

MYO6
Unconventional myosin-VI

1

12

High-throughput

0.479

High

666665

BAIP2
BAR/IMD domain-containing adapter protein 2

1

20

High-throughput

0.479

High

666667

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.479

High

446513

SNRPA
U1 small nuclear ribonucleoprotein A

1

6

High-throughput

0.457

High

666562

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.457

High

666563

BIEA
Biliverdin reductase A

1

1

High-throughput

0.457

High

666573

RACK1
Small ribosomal subunit protein RACK1

1

10

High-throughput

0.457

High

666620

PHF6
PHD finger protein 6

1

6

High-throughput

0.457

High

666643

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

13

High-throughput

0.457

High

666661

RALY
RNA-binding protein Raly

1

5

High-throughput

0.457

High

666630

RAB1C
Putative Ras-related protein Rab-1C

1

15

High-throughput

0.445

High

123859

SPT5H
Transcription elongation factor SPT5

1

18

High-throughput

0.437

High

266655

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

1

High-throughput

0.437

High

520693

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

7

High-throughput

0.437

High

531733

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.437

High

534043

COBA2

1

3

High-throughput

0.437

High

602392

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

2

High-throughput

0.437

High

666574

RT05
Small ribosomal subunit protein uS5m

1

6

High-throughput

0.437

High

666575

RT06
Small ribosomal subunit protein bS6m

1

1

High-throughput

0.437

High

666576

RT09
Small ribosomal subunit protein uS9m

1

4

High-throughput

0.437

High

666587

GRSF1
G-rich sequence factor 1

1

20

High-throughput

0.437

High

666589

RM28
Large ribosomal subunit protein bL28m

1

3

High-throughput

0.437

High

666593

PWP1
Periodic tryptophan protein 1 homolog

1

14

High-throughput

0.437

High

666603

RABE1
Rab GTPase-binding effector protein 1

1

10

High-throughput

0.437

High

666605

TRIPB
Thyroid receptor-interacting protein 11

1

20

High-throughput

0.437

High

666617

PABP2
Polyadenylate-binding protein 2

1

7

High-throughput

0.437

High

666619

NUDC3
NudC domain-containing protein 3

1

8

High-throughput

0.437

High

666621

RM43
Large ribosomal subunit protein mL43

1

1

High-throughput

0.437

High

666629

RT31
Small ribosomal subunit protein mS31

1

4

High-throughput

0.437

High

666632

SYAP1
Synapse-associated protein 1

1

7

High-throughput

0.437

High

666633

P5CR2
Pyrroline-5-carboxylate reductase 2

1

4

High-throughput

0.437

High

666639

CDCA3
Cell division cycle-associated protein 3

1

12

High-throughput

0.437

High

666644

RM37
Large ribosomal subunit protein mL37

1

2

High-throughput

0.437

High

666645

NAA50
N-alpha-acetyltransferase 50

1

1

High-throughput

0.437

High

666646

RAB1B
Ras-related protein Rab-1B

1

14

High-throughput

0.437

High

666648

UN45A
Protein unc-45 homolog A

1

15

High-throughput

0.437

High

666655

TECR
Very-long-chain enoyl-CoA reductase

1

6

High-throughput

0.437

High

666656

GGA3
ADP-ribosylation factor-binding protein GGA3

1

20

High-throughput

0.437

High

666657

RAI14
Ankycorbin

1

20

High-throughput

0.437

High

666659

TRM7
tRNA

1

8

High-throughput

0.437

High

666664

ANR26
Ankyrin repeat domain-containing protein 26

1

16

High-throughput

0.437

High

666666

SBDS
Ribosome maturation protein SBDS

1

1

High-throughput

0.437

High

666557

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.261

Low

666600

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.261

Low

127722

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.249

Low

666641

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.249

Low

666653

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024