Protein: GROU
Protein groucho (Enhancer of split m9/10 protein) (E(spl)m9/10)

Gene: GROU, gro
Organism: Drosophila melanogaster
Interactions: 88
UniProt ID: P16371

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

594669

GROU
Protein groucho

4

17

Small-scale

0.873

High

569351

HAIR
Protein hairy

16

20

Small-scale

0.765

High

560176

ESM7
Enhancer of split m7 protein

10

20

Small-scale

0.754

High

560201

ESM8
Enhancer of split m8 protein

9

20

Small-scale

0.750

High

393684

HMEN
Segmentation polarity homeobox protein engrailed

7

20

Small-scale

0.744

High

594686

ESMD
Enhancer of split mdelta protein

6

20

Small-scale

0.734

High

560163

ESM5
Enhancer of split m5 protein

5

20

Small-scale

0.706

High

594683

ESM3
Enhancer of split m3 protein

5

20

Small-scale

0.706

High

594687

HLES
Protein hairless

5

13

Small-scale

0.705

High

594691

DPN
Protein deadpan

5

20

Small-scale

0.696

High

594725

Q9W0Q1
non-specific serine/threonine protein kinase

4

19

Small-scale

0.696

High

594728

Q9XTN4
Brinker

4

1

Small-scale

0.690

High

594672

RUNT
Segmentation protein Runt

4

9

Small-scale

0.684

High

594698

PANG2
Protein pangolin, isoform J

4

20

Small-scale

0.680

High

444058

EVE
Segmentation protein even-skipped

3

20

Small-scale

0.648

High

594684

ESMB
Enhancer of split mbeta protein

3

20

Small-scale

0.648

High

594685

ESMC
Enhancer of split mgamma protein

3

20

Small-scale

0.648

High

594717

Q9VN10
Huckebein

3

2

Small-scale

0.648

High

381689

H3
Histone H3

2

10

Small-scale

0.638

High

594692

SO
Protein sine oculis

3

20

Small-scale

0.625

High

594699

HDAC1
Histone deacetylase HDAC1

3

17

Small-scale

0.625

High

594674

SLP1
Fork head domain transcription factor slp1

2

20

Small-scale

0.600

High

594724

Q9VWX7
HES-related

2

20

Small-scale

0.600

High

594726

MYC
Myc proto-oncogene protein

1

16

Small-scale

0.589

High

532113

KNIR
Zygotic gap protein knirps

1

20

Small-scale

0.586

High

234448

CTBP
C-terminal-binding protein

2

9

Small-scale

0.584

High

594671

VND
Homeobox protein vnd

2

20

Small-scale

0.584

High

594695

Q7KUL4
Intermediate neuroblasts defective

2

18

Small-scale

0.584

High

594682

PANG1
Protein pangolin, isoforms A/H/I/S

2

20

Small-scale

0.563

High

594679

GSC
Homeobox protein goosecoid

2

20

High-throughput

0.560

High

594681

H4
Histone H4

1

7

Small-scale

0.553

High

583354

DORS
Embryonic polarity protein dorsal

2

7

Small-scale

0.552

High

594706

CIC
Putative transcription factor capicua

2

20

Small-scale

0.552

High

466810

KRH1
Krueppel homolog 1

1

1

High-throughput

0.541

High

594673

ETS3
DNA-binding protein D-ETS-3

1

15

High-throughput

0.541

High

594675

FTZF1
Nuclear hormone receptor FTZ-F1

1

20

High-throughput

0.541

High

594676

SALM
Homeotic protein spalt-major

1

11

High-throughput

0.541

High

594678

E78C
Ecdysone-induced protein 78C

1

20

High-throughput

0.541

High

594689

DICH
SOX domain-containing protein dichaete

1

20

High-throughput

0.541

High

594697

TAD2B
Transcriptional adapter 2b

1

7

High-throughput

0.541

High

594707

TIPT
Protein tiptop

1

1

High-throughput

0.541

High

594709

Q9VAY8
Buddy of Hmr 1

1

2

High-throughput

0.541

High

594720

BOWEL
Protein bowel

1

2

High-throughput

0.541

High

594688

Q0E8K8
FI21816p1

1

8

High-throughput

0.536

High

594677

PEP
Zinc finger protein on ecdysone puffs

1

0

High-throughput

0.518

High

594722

Q9VTE8
GEO08928p1

1

0

High-throughput

0.518

High

356285

O97102
Small ubiquitin-related modifier

1

2

Small-scale

0.515

High

305086

UNC4
Homeobox protein unc-4

1

20

High-throughput

0.508

High

431428

HMIN
Homeobox protein invected

1

20

High-throughput

0.508

High

517330

HMH2
Homeobox protein H2.0

1

20

High-throughput

0.508

High

594710

Q9VDA2
Ladybird late, isoform A

1

20

High-throughput

0.508

High

594694

Q7KNM2
Dorsal interacting protein 4

1

9

High-throughput

0.492

High

594719

INT15
Integrator complex subunit 15

1

0

High-throughput

0.486

High

95376

E1JJ76
Alhambra, isoform H

1

20

High-throughput

0.481

High

594680

UBX
Homeotic protein ultrabithorax

1

20

High-throughput

0.481

High

594693

Q5U156
RE01954p

1

8

High-throughput

0.481

High

594729

Q9XYM5
LD27861p

1

7

High-throughput

0.481

High

54258

A1Z8F4
Schnurri, isoform D

1

4

Small-scale

0.479

High

197559

PAX6
Paired box protein Pax-6

1

20

Small-scale

0.479

High

518484

AST4
Achaete-scute complex protein T4

1

6

Small-scale

0.479

High

594696

Q7KVG9
Chip, isoform B

1

2

Small-scale

0.479

High

594700

OPTIX
Protein Optix

1

20

Small-scale

0.479

High

594703

Q9GRA9
Master of thick veins

1

16

Small-scale

0.479

High

594704

Q9N693
Brakeless-B

1

20

Small-scale

0.479

High

594705

Q9NHP8
GTX/Nkx6B-like homeodomain protein

1

20

Small-scale

0.479

High

594708

ASF1
Histone chaperone asf1

1

1

Small-scale

0.479

High

594713

Q9VJ16
GH26014p

1

20

Small-scale

0.479

High

594714

ELBOW
Zinc finger protein Elbow

1

7

Small-scale

0.479

High

594716

Q9VMR2
LP04777p

1

20

Small-scale

0.479

High

560154

ESM4
Enhancer of split m4 protein

1

0

Small-scale

0.460

High

380842

H1
Histone H1

1

0

Small-scale

0.458

High

2380

A0A0B4KER0
Relative of woc, isoform C

1

8

High-throughput

0.457

High

2401

A0A0B4KGP1
Alhambra, isoform P

1

11

High-throughput

0.457

High

53381

A1Z7P5
Suppressor of variegation 2-10, isoform I

1

7

High-throughput

0.457

High

594702

Q961V5
GH04704p

1

20

High-throughput

0.457

High

122345

M9PIW5
Uncharacterized protein, isoform B

1

1

High-throughput

0.439

High

594718

Q9VN42
Dorsal interacting protein 2

1

1

Small-scale

0.439

High

594727

Q9W4U0
Uncharacterized protein, isoform A

1

1

High-throughput

0.417

High

594670

TIN
Muscle-specific homeobox protein tinman

1

20

High-throughput

0.381

High

594690

DRI
Protein dead ringer

1

12

High-throughput

0.381

High

594701

Q960G9
SD02279p

1

1

High-throughput

0.348

High

594723

Q9VWX6
Holes in muscle

2

0

Small-scale

0.305

High

356500

O97111
LD29223p

1

0

High-throughput

0.265

Low

594711

Q9VFM2
FI08034p

1

0

High-throughput

0.265

Low

594712

Q9VGM5
IP07109p

1

0

High-throughput

0.265

Low

594721

Q9VT66
GEO02549p1

1

0

High-throughput

0.265

Low

594715

Q9VK15
Protein Mabiki

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025