Protein: ATR
Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)

Gene: ATR
Organism: Homo sapiens
Interactions: 194
UniProt ID: Q13535

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000723 - telomere maintenance
GO:0003677 - DNA binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1038107

ATR
Serine/threonine-protein kinase ATR

4

17

Small-scale

0.874

High

337465

ABL1
Tyrosine-protein kinase ABL1

2

4

Small-scale

0.792

High

1038144

ATRIP
ATR-interacting protein

27

5

Small-scale

0.768

High

181855

SOCS1
Suppressor of cytokine signaling 1

2

20

Small-scale

0.754

High

154181

CHK1
Serine/threonine-protein kinase Chk1

10

4

Small-scale

0.752

High

749468

BRCA1
Breast cancer type 1 susceptibility protein

8

12

Small-scale

0.752

High

386684

P53
Cellular tumor antigen p53

8

7

Small-scale

0.751

High

1038160

CDC5L
Cell division cycle 5-like protein

1

2

Small-scale

0.747

High

1031513

ATM
Serine-protein kinase ATM

2

18

Small-scale

0.738

High

246222

NBN
Nibrin

5

6

Small-scale

0.726

High

790975

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

7

Small-scale

0.724

High

1038199

TELO2
Telomere length regulation protein TEL2 homolog

5

16

Small-scale

0.716

High

279015

RAD17
Cell cycle checkpoint protein RAD17

5

6

Small-scale

0.713

High

1038145

TOPB1
DNA topoisomerase 2-binding protein 1

5

14

Small-scale

0.713

High

794247

MSH2
DNA mismatch repair protein Msh2

4

6

Small-scale

0.692

High

651136

RFA1
Replication protein A 70 kDa DNA-binding subunit

4

7

Small-scale

0.671

High

1038186

PD1L1
Programmed cell death 1 ligand 1

3

12

High-throughput

0.667

High

1038117

RHEB
GTP-binding protein Rheb

1

13

Small-scale

0.648

High

1038185

DTL
Denticleless protein homolog

1

8

Small-scale

0.647

High

552661

RFA2
Replication protein A 32 kDa subunit

3

9

Small-scale

0.646

High

1038111

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

3

11

Small-scale

0.631

High

362192

GLPA
Glycophorin-A

2

3

High-throughput

0.628

High

452416

PGFRB
Platelet-derived growth factor receptor beta

2

15

High-throughput

0.628

High

723038

OPRM
Mu-type opioid receptor

2

13

High-throughput

0.628

High

612479

XPA
DNA repair protein complementing XP-A cells

2

2

Small-scale

0.624

High

195907

TTI1
TELO2-interacting protein 1 homolog

2

16

Small-scale

0.621

High

1038179

DCA13
DDB1- and CUL4-associated factor 13

1

4

Small-scale

0.618

High

246349

SCN2B
Sodium channel subunit beta-2

3

10

High-throughput

0.609

High

310281

LYPD3
Ly6/PLAUR domain-containing protein 3

3

1

High-throughput

0.609

High

726191

BASI
Basigin

3

8

High-throughput

0.609

High

1038120

CEA21
Carcinoembryonic antigen-related cell adhesion molecule 21

3

3

High-throughput

0.609

High

1038126

SCAR3
Scavenger receptor class A member 3

3

1

High-throughput

0.609

High

1038153

VSIG2
V-set and immunoglobulin domain-containing protein 2

3

4

High-throughput

0.609

High

1038191

CAH14
Carbonic anhydrase 14

3

2

High-throughput

0.609

High

331278

CHK2
Serine/threonine-protein kinase Chk2

2

19

Small-scale

0.602

High

1038168

FACD2
Fanconi anemia group D2 protein

2

3

Small-scale

0.602

High

1038183

ETAA1
Ewing's tumor-associated antigen 1

2

0

Small-scale

0.598

High

1038155

UHRF2
E3 ubiquitin-protein ligase UHRF2

2

8

Small-scale

0.595

High

1031848

MTA1
Metastasis-associated protein MTA1

2

2

Small-scale

0.584

High

1038193

CE164
Centrosomal protein of 164 kDa

1

7

Small-scale

0.578

High

409774

GLPB
Glycophorin-B

2

3

High-throughput

0.574

High

545107

PVR
Poliovirus receptor

2

1

High-throughput

0.574

High

584400

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

6

High-throughput

0.574

High

702344

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

1

High-throughput

0.574

High

1038124

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

2

7

High-throughput

0.574

High

1038127

VASN
Vasorin

2

4

High-throughput

0.574

High

1038135

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

5

High-throughput

0.574

High

1038182

SCN3B
Sodium channel regulatory subunit beta-3

2

8

High-throughput

0.574

High

556860

CREB1
Cyclic AMP-responsive element-binding protein 1

1

2

Small-scale

0.569

High

418249

NPM
Nucleophosmin

1

2

Small-scale

0.561

High

524915

XRCC5
X-ray repair cross-complementing protein 5

1

4

Small-scale

0.561

High

840434

ETV1
ETS translocation variant 1

1

7

Small-scale

0.561

High

867586

BLM
RecQ-like DNA helicase BLM

1

11

Small-scale

0.561

High

998667

EP300
Histone acetyltransferase p300

1

13

Small-scale

0.561

High

1038163

CDC6
Cell division control protein 6 homolog

1

5

Small-scale

0.561

High

1038174

CLSPN
Claspin

2

0

Small-scale

0.559

High

841711

CDK9
Cyclin-dependent kinase 9

1

4

Small-scale

0.554

High

893980

CDC42
Cell division control protein 42 homolog

1

13

High-throughput

0.553

High

1038175

RHOF
Rho-related GTP-binding protein RhoF

1

16

High-throughput

0.553

High

556505

LEUK
Leukosialin

1

1

High-throughput

0.536

High

563088

YBOX3
Y-box-binding protein 3

1

3

High-throughput

0.536

High

734928

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

13

High-throughput

0.536

High

801124

KI67
Proliferation marker protein Ki-67

1

7

High-throughput

0.536

High

1038109

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1038133

PABP2
Polyadenylate-binding protein 2

1

4

High-throughput

0.536

High

1038143

HELQ
Helicase POLQ-like

1

2

Small-scale

0.536

High

1038146

HDAC2
Histone deacetylase 2

1

7

Small-scale

0.536

High

1038150

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

6

High-throughput

0.536

High

1038154

OPALI
Opalin

1

3

High-throughput

0.536

High

1038166

CINP
Cyclin-dependent kinase 2-interacting protein

1

0

Small-scale

0.530

High

787226

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

11

Small-scale

0.527

High

1038202

NEMO
NF-kappa-B essential modulator

1

9

Small-scale

0.515

High

827195

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.513

High

1038137

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.513

High

120913

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

Small-scale

0.501

High

555452

H2AX
Histone H2AX

1

10

Small-scale

0.501

High

832436

MCM2
DNA replication licensing factor MCM2

1

9

Small-scale

0.501

High

963611

E2F1
Transcription factor E2F1

1

4

Small-scale

0.501

High

1038139

MCPH1
Microcephalin

1

1

Small-scale

0.501

High

1038148

RENT1
Regulator of nonsense transcripts 1

1

8

Small-scale

0.501

High

1038158

DCR1C
Protein artemis

1

4

Small-scale

0.501

High

1038159

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

8

Small-scale

0.501

High

1038180

FANCI
Fanconi anemia group I protein

1

1

Small-scale

0.501

High

1038181

AATF
Protein AATF

1

1

Small-scale

0.501

High

1038198

DCAF1
DDB1- and CUL4-associated factor 1

1

11

Small-scale

0.501

High

171992

GP182
G-protein coupled receptor 182

1

20

High-throughput

0.489

High

196773

CYB5B
Cytochrome b5 type B

1

2

High-throughput

0.489

High

639582

TNR5
Tumor necrosis factor receptor superfamily member 5

1

6

High-throughput

0.489

High

702221

CD70
CD70 antigen

1

1

High-throughput

0.489

High

706895

CD80
T-lymphocyte activation antigen CD80

1

13

High-throughput

0.489

High

856376

EFNA4
Ephrin-A4

1

5

High-throughput

0.489

High

856604

EFNA5
Ephrin-A5

1

5

High-throughput

0.489

High

960780

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.489

High

1028477

KLRD1
Natural killer cells antigen CD94

1

5

High-throughput

0.489

High

1030924

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

20

High-throughput

0.489

High

1038113

FXYD3
FXYD domain-containing ion transport regulator 3

1

1

High-throughput

0.489

High

1038119

CD226
CD226 antigen

1

11

High-throughput

0.489

High

1038132

B3GN8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

1

2

High-throughput

0.489

High

1038138

LRC25
Leucine-rich repeat-containing protein 25

1

3

High-throughput

0.489

High

1038141

F174A
Membrane protein FAM174A

1

1

High-throughput

0.489

High

1038142

HUMMR
Protein MGARP

1

1

High-throughput

0.489

High

1038169

SEM4C
Semaphorin-4C

1

11

High-throughput

0.489

High

1038170

FXYD6
FXYD domain-containing ion transport regulator 6

1

1

High-throughput

0.489

High

1038171

F234A
Protein FAM234A

1

3

High-throughput

0.489

High

1038188

HCST
Hematopoietic cell signal transducer

1

3

High-throughput

0.489

High

1038190

CC018
Uncharacterized protein C3orf18

1

3

High-throughput

0.489

High

1038197

GPR55
G-protein coupled receptor 55

1

20

High-throughput

0.489

High

1038200

GPR45
Probable G-protein coupled receptor 45

1

11

High-throughput

0.489

High

1038201

NPTN
Neuroplastin

1

8

High-throughput

0.489

High

167540

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

19

Small-scale

0.481

High

176597

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.480

High

1038131

DPOLN
DNA polymerase nu

1

0

Small-scale

0.480

High

205367

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

217476

AIRE
Autoimmune regulator

1

12

Small-scale

0.479

High

227378

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

244399

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.479

High

296016

MTA2
Metastasis-associated protein MTA2

1

2

Small-scale

0.479

High

318616

EYA4
Eyes absent homolog 4

1

1

High-throughput

0.479

High

338387

EGFR
Epidermal growth factor receptor

1

9

High-throughput

0.479

High

431823

HS90A
Heat shock protein HSP 90-alpha

1

13

Small-scale

0.479

High

532521

TCTP
Translationally-controlled tumor protein

1

3

High-throughput

0.479

High

594191

MSH3
DNA mismatch repair protein Msh3

1

6

Small-scale

0.479

High

599793

5NTD
5'-nucleotidase

1

1

High-throughput

0.479

High

614025

TBG1
Tubulin gamma-1 chain

1

6

Small-scale

0.479

High

708894

MCM7
DNA replication licensing factor MCM7

1

8

Small-scale

0.479

High

714216

HSP74
Heat shock 70 kDa protein 4

1

10

Small-scale

0.479

High

720397

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

790767

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

9

Small-scale

0.479

High

855472

MSH6
DNA mismatch repair protein Msh6

1

7

Small-scale

0.479

High

858621

PPP5
Serine/threonine-protein phosphatase 5

1

13

Small-scale

0.479

High

869812

PMS1
PMS1 protein homolog 1

1

4

High-throughput

0.479

High

881166

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.479

High

917225

H4
Histone H4

1

6

High-throughput

0.479

High

967026

XPC
DNA repair protein complementing XP-C cells

1

1

Small-scale

0.479

High

967866

PO5F1
POU domain, class 5, transcription factor 1

1

4

High-throughput

0.479

High

1018945

TP53B
TP53-binding protein 1

1

6

High-throughput

0.479

High

1034841

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

11

High-throughput

0.479

High

1035697

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1038108

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.479

High

1038110

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1038112

SMC1A
Structural maintenance of chromosomes protein 1A

1

8

Small-scale

0.479

High

1038114

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

8

Small-scale

0.479

High

1038115

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1038118

NCOA2
Nuclear receptor coactivator 2

1

6

Small-scale

0.479

High

1038128

CDC73
Parafibromin

1

2

Small-scale

0.479

High

1038130

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1038136

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

9

Small-scale

0.479

High

1038140

SNIP1
Smad nuclear-interacting protein 1

1

1

Small-scale

0.479

High

1038156

NEK1
Serine/threonine-protein kinase Nek1

1

17

Small-scale

0.479

High

1038161

PHB2
Prohibitin-2

1

2

High-throughput

0.479

High

1038164

RN126
E3 ubiquitin-protein ligase RNF126

1

4

Small-scale

0.479

High

1038167

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

15

High-throughput

0.479

High

1038176

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

Small-scale

0.479

High

1038178

ZDH18
Palmitoyltransferase ZDHHC18

1

3

High-throughput

0.479

High

1038116

PLEC
Plectin

1

5

High-throughput

0.470

High

238268

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.458

High

245899

HUS1
Checkpoint protein HUS1

1

0

Small-scale

0.458

High

417269

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

1038125

INT3
Integrator complex subunit 3

1

0

Small-scale

0.458

High

1038149

FBX32
F-box only protein 32

1

0

Small-scale

0.458

High

1038162

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.458

High

1038165

TIPIN
TIMELESS-interacting protein

1

0

Small-scale

0.458

High

1038173

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.458

High

1038189

MUTYH
Adenine DNA glycosylase

1

0

Small-scale

0.458

High

354439

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.445

High

1038195

RUVB1
RuvB-like 1

1

19

Small-scale

0.445

High

123587

PGRC1
Membrane-associated progesterone receptor component 1

1

1

Small-scale

0.437

High

839273

5HT6R
5-hydroxytryptamine receptor 6

1

6

Small-scale

0.437

High

1038129

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

1038151

SPSB1
SPRY domain-containing SOCS box protein 1

1

11

Small-scale

0.437

High

1038152

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

1038172

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1038184

MTMR4
Myotubularin-related protein 4

1

5

High-throughput

0.437

High

1038196

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

6

Small-scale

0.437

High

1038157

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1038192

TIM
Protein timeless homolog

1

0

Small-scale

0.426

High

119961

AP3B1
AP-3 complex subunit beta-1

1

5

Small-scale

0.408

High

658359

DPOD1
DNA polymerase delta catalytic subunit

1

2

Small-scale

0.408

High

836831

DNLI4
DNA ligase 4

1

3

Small-scale

0.408

High

837010

MRE11
Double-strand break repair protein MRE11

1

6

Small-scale

0.408

High

847795

BRCA2
Breast cancer type 2 susceptibility protein

1

2

Small-scale

0.408

High

1014008

AP1B1
AP-1 complex subunit beta-1

1

5

Small-scale

0.408

High

1038123

E4F1
Transcription factor E4F1

1

3

Small-scale

0.408

High

1038177

RASF1
Ras association domain-containing protein 1

1

6

Small-scale

0.408

High

1038194

PA2G4
Proliferation-associated protein 2G4

1

2

Small-scale

0.408

High

1038147

ARHG1
Rho guanine nucleotide exchange factor 1

1

4

Small-scale

0.373

High

848843

AL3A2
Aldehyde dehydrogenase family 3 member A2

3

0

High-throughput

0.347

High

858148

NAR1
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

1

0

High-throughput

0.279

Low

1038121

F133B
Protein FAM133B

1

0

High-throughput

0.279

Low

1038122

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

1038134

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.279

Low

1038187

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

986422

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

0

Small-scale

0.213

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024