Protein: MTREX
Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase)

Gene: MTREX
Organism: Homo sapiens
Interactions: 194
UniProt ID: P42285

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000460 - maturation of 5.8S rRNA
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

786935

NCBP1
Nuclear cap-binding protein subunit 1

2

6

High-throughput

0.776

High

786929

EXOSX
Exosome complex component 10

2

5

High-throughput

0.754

High

787040

RBM7
RNA-binding protein 7

6

16

High-throughput

0.736

High

787020

EXOS3
Exosome complex component RRP40

4

3

High-throughput

0.699

High

786952

EXOS7
Exosome complex component RRP42

4

12

High-throughput

0.694

High

230318

ZC3H1
Zinc finger C3H1 domain-containing protein

1

4

High-throughput

0.691

High

786933

DHX9
ATP-dependent RNA helicase A

1

17

High-throughput

0.691

High

787022

DDX21
Nucleolar RNA helicase 2

1

18

High-throughput

0.691

High

346148

MYC
Myc proto-oncogene protein

4

20

High-throughput

0.676

High

787019

EXOS5
Exosome complex component RRP46

3

15

High-throughput

0.675

High

787017

EXOS4
Exosome complex component RRP41

3

13

Small-scale

0.667

High

787002

MPH6
M-phase phosphoprotein 6

4

0

Small-scale

0.658

High

786961

IF16
Gamma-interferon-inducible protein 16

3

13

High-throughput

0.656

High

786970

ZCHC8
Zinc finger CCHC domain-containing protein 8

4

0

Small-scale

0.651

High

786945

EXOS2
Exosome complex component RRP4

3

5

Small-scale

0.650

High

672023

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

5

High-throughput

0.635

High

787013

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.622

High

786924

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

5

High-throughput

0.621

High

786966

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

3

5

High-throughput

0.619

High

267941

EED
Polycomb protein EED

1

20

High-throughput

0.618

High

294482

RECQ4
ATP-dependent DNA helicase Q4

1

19

High-throughput

0.618

High

684480

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.618

High

786905

RECQ1
ATP-dependent DNA helicase Q1

1

17

High-throughput

0.618

High

786920

H4
Histone H4

1

7

High-throughput

0.618

High

786937

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

14

High-throughput

0.618

High

786948

DHX8
ATP-dependent RNA helicase DHX8

1

17

High-throughput

0.618

High

786950

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

14

High-throughput

0.618

High

786997

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

20

High-throughput

0.618

High

787005

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

14

High-throughput

0.618

High

787024

RNC
Ribonuclease 3

1

10

High-throughput

0.618

High

787033

HECD1
E3 ubiquitin-protein ligase HECTD1

1

18

High-throughput

0.618

High

787034

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.618

High

786916

RBM11
Splicing regulator RBM11

2

20

High-throughput

0.611

High

786917

1433G
14-3-3 protein gamma

2

10

High-throughput

0.611

High

787038

EXOS1
Exosome complex component CSL4

2

8

High-throughput

0.611

High

786946

C1D
Nuclear nucleic acid-binding protein C1D

2

0

High-throughput

0.602

High

778957

CCNF
Cyclin-F

2

7

High-throughput

0.601

High

786913

NCBP2
Nuclear cap-binding protein subunit 2

2

17

High-throughput

0.601

High

786962

EXOS6
Exosome complex component MTR3

2

16

High-throughput

0.586

High

386250

P53
Cellular tumor antigen p53

2

5

High-throughput

0.584

High

552138

RFA2
Replication protein A 32 kDa subunit

2

12

High-throughput

0.584

High

650571

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

10

High-throughput

0.584

High

719875

RFA3
Replication protein A 14 kDa subunit

2

8

High-throughput

0.584

High

786944

CUL3
Cullin-3

2

19

High-throughput

0.584

High

786991

DI3L1
DIS3-like exonuclease 1

2

7

Small-scale

0.584

High

786996

EXOS8
Exosome complex component RRP43

2

12

High-throughput

0.584

High

787027

MCM9
DNA helicase MCM9

2

6

Small-scale

0.584

High

786927

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

2

5

High-throughput

0.580

High

683183

1433B
14-3-3 protein beta/alpha

2

10

High-throughput

0.574

High

369133

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

726635

FUS
RNA-binding protein FUS

2

20

High-throughput

0.571

High

786967

A16L1
Autophagy-related protein 16-1

1

17

High-throughput

0.553

High

786973

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.553

High

786983

MIB1
E3 ubiquitin-protein ligase MIB1

1

3

High-throughput

0.553

High

157013

AIM2
Interferon-inducible protein AIM2

1

13

High-throughput

0.536

High

236892

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

3

High-throughput

0.536

High

403112

LA
Lupus La protein

1

18

High-throughput

0.536

High

431623

HS90A
Heat shock protein HSP 90-alpha

1

11

High-throughput

0.536

High

446533

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.536

High

508382

TOP1
DNA topoisomerase 1

1

7

High-throughput

0.536

High

540920

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

9

High-throughput

0.536

High

742107

SYUA
Alpha-synuclein

1

5

High-throughput

0.536

High

781709

MNDA
Myeloid cell nuclear differentiation antigen

1

13

High-throughput

0.536

High

786904

KSYK
Tyrosine-protein kinase SYK

1

10

High-throughput

0.536

High

786906

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.536

High

786907

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.536

High

786910

CLK2
Dual specificity protein kinase CLK2

1

11

High-throughput

0.536

High

786919

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.536

High

786923

1433Z
14-3-3 protein zeta/delta

1

10

High-throughput

0.536

High

786926

CSK21
Casein kinase II subunit alpha

1

11

High-throughput

0.536

High

786960

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

10

High-throughput

0.536

High

786980

ZCH18
Zinc finger CCCH domain-containing protein 18

1

9

High-throughput

0.536

High

786989

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

3

High-throughput

0.536

High

787001

CDC5L
Cell division cycle 5-like protein

1

10

High-throughput

0.536

High

787041

OAS3
2'-5'-oligoadenylate synthase 3

1

1

High-throughput

0.536

High

255569

OBSL1
Obscurin-like protein 1

2

6

High-throughput

0.533

High

786979

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

787010

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.513

High

786995

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

High-throughput

0.501

High

646703

1433T
14-3-3 protein theta

1

10

High-throughput

0.489

High

786911

RB27A
Ras-related protein Rab-27A

1

1

High-throughput

0.489

High

786931

1433F
14-3-3 protein eta

1

10

High-throughput

0.489

High

329145

F107A
Actin-associated protein FAM107A

1

1

Small-scale

0.481

High

786985

XRN1
5'-3' exoribonuclease 1

1

5

High-throughput

0.481

High

122542

MEN1
Menin

1

5

High-throughput

0.479

High

125215

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

12

High-throughput

0.479

High

148491

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

162472

XPO1
Exportin-1

1

9

High-throughput

0.479

High

224342

RAD21
Double-strand-break repair protein rad21 homolog

1

2

High-throughput

0.479

High

226754

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

233266

NUPR1
Nuclear protein 1

1

6

High-throughput

0.479

High

241468

H2B1K
Histone H2B type 1-K

1

11

High-throughput

0.479

High

244064

BRD4
Bromodomain-containing protein 4

1

19

High-throughput

0.479

High

298244

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.479

High

331739

NSD2
Histone-lysine N-methyltransferase NSD2

1

11

Small-scale

0.479

High

379096

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

384429

NTRK1
High affinity nerve growth factor receptor

1

11

High-throughput

0.479

High

441927

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

20

High-throughput

0.479

High

455181

PARP1
Poly [ADP-ribose] polymerase 1

1

10

High-throughput

0.479

High

487201

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

569335

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

582115

NUCL
Nucleolin

1

14

High-throughput

0.479

High

615667

GCSP
Glycine dehydrogenase

1

3

High-throughput

0.479

High

714493

GRK5
G protein-coupled receptor kinase 5

1

7

High-throughput

0.479

High

717523

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.479

High

737630

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

High-throughput

0.479

High

786903

MATR3
Matrin-3

1

7

High-throughput

0.479

High

786908

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

12

High-throughput

0.479

High

786912

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

13

High-throughput

0.479

High

786915

FOXA1
Hepatocyte nuclear factor 3-alpha

1

19

High-throughput

0.479

High

786918

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.479

High

786921

H2B1C
Histone H2B type 1-C/E/F/G/I

1

11

High-throughput

0.479

High

786922

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.479

High

786925

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.479

High

786928

VIGLN
Vigilin

1

13

High-throughput

0.479

High

786930

MECOM
Histone-lysine N-methyltransferase MECOM

1

5

High-throughput

0.479

High

786932

EXOS9
Exosome complex component RRP45

1

12

High-throughput

0.479

High

786936

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

786939

NFX1
Transcriptional repressor NF-X1

1

11

High-throughput

0.479

High

786940

TADBP
TAR DNA-binding protein 43

1

16

High-throughput

0.479

High

786941

TIF1B
Transcription intermediary factor 1-beta

1

14

High-throughput

0.479

High

786942

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

786943

CUL1
Cullin-1

1

19

High-throughput

0.479

High

786947

RBM39
RNA-binding protein 39

1

13

High-throughput

0.479

High

786953

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

11

High-throughput

0.479

High

786954

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

786955

RNPS1
RNA-binding protein with serine-rich domain 1

1

20

High-throughput

0.479

High

786956

SF3A1
Splicing factor 3A subunit 1

1

5

High-throughput

0.479

High

786959

E2F4
Transcription factor E2F4

1

3

High-throughput

0.479

High

786964

RC3H1
Roquin-1

1

7

High-throughput

0.479

High

786969

ZN746
Zinc finger protein 746

1

3

High-throughput

0.479

High

786972

GGYF2
GRB10-interacting GYF protein 2

1

1

High-throughput

0.479

High

786974

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

786975

MEPCE
7SK snRNA methylphosphate capping enzyme

1

4

High-throughput

0.479

High

786976

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

786977

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

9

Small-scale

0.479

High

786978

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

5

Small-scale

0.479

High

786981

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

8

High-throughput

0.479

High

786988

SIR6
NAD-dependent protein deacylase sirtuin-6

1

9

High-throughput

0.479

High

786990

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

786992

RBP56
TATA-binding protein-associated factor 2N

1

12

High-throughput

0.479

High

786993

CSN5
COP9 signalosome complex subunit 5

1

12

High-throughput

0.479

High

786994

FUBP2
Far upstream element-binding protein 2

1

12

Small-scale

0.479

High

786998

DDRGK
DDRGK domain-containing protein 1

1

6

High-throughput

0.479

High

787000

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

4

High-throughput

0.479

High

787003

TBX5
T-box transcription factor TBX5

1

4

High-throughput

0.479

High

787004

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

787006

RIOK1
Serine/threonine-protein kinase RIO1

1

8

High-throughput

0.479

High

787008

FACD2
Fanconi anemia group D2 protein

1

11

High-throughput

0.479

High

787009

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

787014

PRD16
Histone-lysine N-methyltransferase PRDM16

1

5

High-throughput

0.479

High

787015

RC3H2
Roquin-2

1

13

High-throughput

0.479

High

787016

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

6

High-throughput

0.479

High

787021

ANLN
Anillin

1

7

High-throughput

0.479

High

787023

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.479

High

787026

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

6

Small-scale

0.479

High

787028

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

787029

NOP53
Ribosome biogenesis protein NOP53

1

2

High-throughput

0.479

High

787031

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

5

High-throughput

0.479

High

787032

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

787035

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

2

High-throughput

0.479

High

787036

TRI33
E3 ubiquitin-protein ligase TRIM33

1

20

High-throughput

0.479

High

787037

RRP44
Exosome complex exonuclease RRP44

1

7

Small-scale

0.479

High

237178

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

786938

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

786957

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.458

High

787007

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.458

High

401579

JUN
Transcription factor Jun

1

17

High-throughput

0.445

High

786949

ZN267
Zinc finger protein 267

1

1

High-throughput

0.445

High

786958

MK11
Mitogen-activated protein kinase 11

1

6

Small-scale

0.445

High

786963

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

786965

BTBD8
BTB/POZ domain-containing protein 8

1

12

High-throughput

0.445

High

787012

LN28A
Protein lin-28 homolog A

1

15

High-throughput

0.445

High

773097

PBX2
Pre-B-cell leukemia transcription factor 2

1

0

Small-scale

0.438

High

786951

CUL7
Cullin-7

1

5

High-throughput

0.437

High

786971

FBX42
F-box only protein 42

1

5

High-throughput

0.437

High

786986

RHG24
Rho GTPase-activating protein 24

1

4

High-throughput

0.437

High

787011

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

787018

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.437

High

787025

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

787039

HBS1L
HBS1-like protein

1

3

High-throughput

0.437

High

786987

ZN808
Zinc finger protein 808

1

0

High-throughput

0.426

High

786909

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

306014

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

16

High-throughput

0.407

High

354042

IGHA1
Immunoglobulin heavy constant alpha 1

1

2

High-throughput

0.407

High

581513

VCAM1
Vascular cell adhesion protein 1

1

4

High-throughput

0.407

High

786999

CEP63
Centrosomal protein of 63 kDa

1

13

High-throughput

0.407

High

375716

GBA1
Lysosomal acid glucosylceramidase

1

0

High-throughput

0.279

Low

786934

MZT1
Mitotic-spindle organizing protein 1

1

0

High-throughput

0.279

Low

786982

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.279

Low

787030

PALS2
Protein PALS2

1

0

High-throughput

0.251

Low

786914

THOP1
Thimet oligopeptidase

1

0

High-throughput

0.249

Low

786968

GRAM4
GRAM domain-containing protein 4

1

0

Small-scale

0.249

Low

786984

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024