Protein: NCOA6
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)

Gene: NCOA6
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q14686

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

903229

WDR5
WD repeat-containing protein 5

11

19

Small-scale

0.760

High

1057800

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

11

12

Small-scale

0.758

High

1057759

RBBP5
Retinoblastoma-binding protein 5

10

20

Small-scale

0.758

High

587169

RXRA
Retinoic acid receptor RXR-alpha

6

20

Small-scale

0.738

High

1057766

PAXI1
PAX-interacting protein 1

6

17

Small-scale

0.735

High

369612

ESR1
Estrogen receptor

6

20

Small-scale

0.735

High

1057773

KMT2C
Histone-lysine N-methyltransferase 2C

6

20

Small-scale

0.734

High

183115

KDM6A
Lysine-specific demethylase 6A

6

13

Small-scale

0.730

High

377327

GCR
Glucocorticoid receptor

5

20

Small-scale

0.707

High

500485

THB
Thyroid hormone receptor beta

5

20

Small-scale

0.704

High

487970

RARA
Retinoic acid receptor alpha

4

20

Small-scale

0.694

High

1057802

KMT2B
Histone-lysine N-methyltransferase 2B

4

20

Small-scale

0.694

High

740524

PPARG
Peroxisome proliferator-activated receptor gamma

5

20

Small-scale

0.691

High

782542

HNF4A
Hepatocyte nuclear factor 4-alpha

4

20

Small-scale

0.688

High

500421

THA
Thyroid hormone receptor alpha

4

20

Small-scale

0.685

High

1057757

NCOA6
Nuclear receptor coactivator 6

3

16

Small-scale

0.680

High

1057781

CBP
CREB-binding protein

3

20

Small-scale

0.669

High

152645

KMT2D
Histone-lysine N-methyltransferase 2D

4

20

Small-scale

0.666

High

523755

XRCC6
X-ray repair cross-complementing protein 6

3

6

Small-scale

0.664

High

1057762

NCOA1
Nuclear receptor coactivator 1

3

9

Small-scale

0.658

High

1057791

PAGR1
PAXIP1-associated glutamate-rich protein 1

3

1

Small-scale

0.656

High

1057780

ESR2
Estrogen receptor beta

3

20

Small-scale

0.655

High

1057792

DPY30
Protein dpy-30 homolog

3

2

Small-scale

0.650

High

1057786

TGS1
Trimethylguanosine synthase

3

0

Small-scale

0.650

High

487433

ANDR
Androgen receptor

2

20

Small-scale

0.631

High

150101

UTY
Histone demethylase UTY

2

13

Small-scale

0.618

High

848219

HCFC1
Host cell factor 1

2

7

Small-scale

0.611

High

874381

NR1H2
Oxysterols receptor LXR-beta

2

20

Small-scale

0.609

High

891768

ACTB
Actin, cytoplasmic 1

2

10

Small-scale

0.602

High

831329

CEBPA
CCAAT/enhancer-binding protein alpha

2

20

Small-scale

0.601

High

386735

P53
Cellular tumor antigen p53

2

10

Small-scale

0.594

High

522986

SRC
Proto-oncogene tyrosine-protein kinase Src

2

9

Small-scale

0.594

High

414288

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.586

High

547800

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

7

Small-scale

0.586

High

524927

XRCC5
X-ray repair cross-complementing protein 5

2

6

Small-scale

0.584

High

818049

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

963623

E2F1
Transcription factor E2F1

1

5

Small-scale

0.573

High

1018957

TP53B
TP53-binding protein 1

1

16

Small-scale

0.569

High

944245

PRKDC
DNA-dependent protein kinase catalytic subunit

1

7

Small-scale

0.561

High

961116

HSF1
Heat shock factor protein 1

1

1

Small-scale

0.561

High

998713

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.561

High

1057767

H32
Histone H3.2

1

15

Small-scale

0.561

High

509950

VDR
Vitamin D3 receptor

1

20

Small-scale

0.552

High

206367

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.549

High

323757

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.536

High

646892

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

684039

1433S
14-3-3 protein sigma

1

20

High-throughput

0.536

High

904565

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

982016

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1057768

TBA1A
Tubulin alpha-1A chain

1

6

Small-scale

0.536

High

1057783

DYL2
Dynein light chain 2, cytoplasmic

1

3

High-throughput

0.536

High

1057790

ASCL2
Achaete-scute homolog 2

1

7

Small-scale

0.536

High

265866

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

20

Small-scale

0.527

High

1057784

RBM14
RNA-binding protein 14

1

9

Small-scale

0.527

High

1057794

ZN335
Zinc finger protein 335

1

1

Small-scale

0.527

High

1057796

TRXR2
Thioredoxin reductase 2, mitochondrial

1

2

Small-scale

0.527

High

950184

SMAD3
Mothers against decapentaplegic homolog 3

1

5

High-throughput

0.508

High

1057763

SMAD2
Mothers against decapentaplegic homolog 2

1

5

High-throughput

0.508

High

345436

FOS
Protein c-Fos

1

14

Small-scale

0.501

High

402011

JUN
Transcription factor Jun

1

14

Small-scale

0.501

High

475764

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.501

High

515592

SRF
Serum response factor

1

1

Small-scale

0.501

High

587577

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

12

Small-scale

0.501

High

589859

TBP
TATA-box-binding protein

1

1

Small-scale

0.501

High

639584

TNR5
Tumor necrosis factor receptor superfamily member 5

1

2

Small-scale

0.501

High

957705

XIAP
E3 ubiquitin-protein ligase XIAP

1

6

High-throughput

0.501

High

978754

TF65
Transcription factor p65

1

4

Small-scale

0.501

High

1057761

MED1
Mediator of RNA polymerase II transcription subunit 1

1

12

Small-scale

0.501

High

1057771

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

3

Small-scale

0.501

High

1057785

NR1H4
Bile acid receptor

1

20

Small-scale

0.501

High

1057806

GRIP1
Glutamate receptor-interacting protein 1

1

4

Small-scale

0.501

High

846412

RORG
Nuclear receptor ROR-gamma

1

20

High-throughput

0.481

High

1025253

NR1H3
Oxysterols receptor LXR-alpha

1

20

High-throughput

0.481

High

1057765

Q58EY0
RAR related orphan receptor B isoform 1

1

20

High-throughput

0.481

High

1057787

RANB9
Ran-binding protein 9

1

14

High-throughput

0.481

High

1057809

FHOD1
FH1/FH2 domain-containing protein 1

1

2

High-throughput

0.481

High

1057810

NCOR2
Nuclear receptor corepressor 2

1

16

Small-scale

0.481

High

855405

TF2AA
Transcription initiation factor IIA subunit 1

1

0

Small-scale

0.480

High

1057799

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.480

High

122759

MEN1
Menin

1

4

High-throughput

0.479

High

171028

TBXT
T-box transcription factor T

1

14

High-throughput

0.479

High

211855

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

455444

PARP1
Poly [ADP-ribose] polymerase 1

1

18

Small-scale

0.479

High

505217

EGR2
E3 SUMO-protein ligase EGR2

1

7

High-throughput

0.479

High

507423

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.479

High

620348

GATA2
Endothelial transcription factor GATA-2

1

18

High-throughput

0.479

High

641410

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

726818

FUS
RNA-binding protein FUS

1

18

High-throughput

0.479

High

808612

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

818804

SOX9
Transcription factor SOX-9

1

20

High-throughput

0.479

High

877731

FOXA1
Hepatocyte nuclear factor 3-alpha

1

14

High-throughput

0.479

High

878071

ANM2
Protein arginine N-methyltransferase 2

1

6

Small-scale

0.479

High

878405

PAX9
Paired box protein Pax-9

1

20

High-throughput

0.479

High

917270

H4
Histone H4

1

8

High-throughput

0.479

High

967175

EWS
RNA-binding protein EWS

1

17

High-throughput

0.479

High

975251

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

High-throughput

0.479

High

1046684

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.479

High

1057758

NUMA1
Nuclear mitotic apparatus protein 1

1

5

Small-scale

0.479

High

1057760

NCOA2
Nuclear receptor coactivator 2

1

11

Small-scale

0.479

High

1057764

SMAD1
Mothers against decapentaplegic homolog 1

1

5

Small-scale

0.479

High

1057769

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

13

High-throughput

0.479

High

1057770

SMC5
Structural maintenance of chromosomes protein 5

1

10

High-throughput

0.479

High

1057772

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

20

Small-scale

0.479

High

1057774

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

8

High-throughput

0.479

High

1057775

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1057776

NUP35
Nucleoporin NUP35

1

4

High-throughput

0.479

High

1057777

MAFA
Transcription factor MafA

1

4

Small-scale

0.479

High

1057778

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

1057779

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

6

High-throughput

0.479

High

1057782

FBXW7
F-box/WD repeat-containing protein 7

1

14

Small-scale

0.479

High

1057789

FEV
Protein FEV

1

20

High-throughput

0.479

High

1057793

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1057795

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1057797

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.479

High

1057798

CXXC1
CXXC-type zinc finger protein 1

1

7

High-throughput

0.479

High

1057801

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

Small-scale

0.479

High

1057803

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

3

High-throughput

0.479

High

1057804

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.479

High

1057805

ASF1A
Histone chaperone ASF1A

1

7

High-throughput

0.479

High

1057807

MAFB
Transcription factor MafB

1

11

Small-scale

0.479

High

1057808

HCFC2
Host cell factor 2

1

9

High-throughput

0.479

High

418277

NPM
Nucleophosmin

1

1

Small-scale

0.457

High

500965

GHR
Growth hormone receptor

1

1

Small-scale

0.457

High

994872

GOGA2
Golgin subfamily A member 2

1

3

High-throughput

0.437

High

1057788

CSF3R
Granulocyte colony-stimulating factor receptor

1

1

Small-scale

0.437

High


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Last updated: 15 Jul 2024