Protein: H3
Histone H3

Gene: H3, His3;
Organism: Drosophila melanogaster
Interactions: 75
UniProt ID: P02299

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000786 - nucleosome
GO:0005700 - polytene chromosome
GO:0006334 - nucleosome assembly
GO:0030527 - structural constituent of chromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

381687

HP1
Heterochromatin protein 1

14

20

Small-scale

0.985

High

381693

PC
Polycomb group protein Pc

6

20

Small-scale

0.935

High

381690

TRX
Histone-lysine N-methyltransferase trithorax

5

20

Small-scale

0.911

High

381702

CAF1
Chromatin assembly factor 1 p55 subunit

4

20

Small-scale

0.904

High

381708

RHINO
Chromo domain-containing protein rhino

3

20

Small-scale

0.882

High

381695

EZ
Histone-lysine N-methyltransferase E(z)

3

20

Small-scale

0.849

High

381700

ESC
Polycomb protein esc

2

16

Small-scale

0.812

High

381727

Q9VCU6
Heterochromatin protein 1c

3

20

Small-scale

0.783

High

381745

Q9W1A9
histone acetyltransferase

2

20

Small-scale

0.778

High

381737

KDM5
Lysine-specific demethylase 5

2

20

Small-scale

0.768

High

381741

ASH1
Histone-lysine N-methyltransferase ash1

2

20

Small-scale

0.768

High

381729

Q9VG78
Protein partner of snf, isoform A

1

20

Small-scale

0.757

High

381696

SUV39
Histone-lysine N-methyltransferase Su(var)3-9

3

20

Small-scale

0.756

High

381744

NU301
Nucleosome-remodeling factor subunit NURF301

3

20

Small-scale

0.739

High

381711

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

20

Small-scale

0.681

High

381719

JIL1
Chromosomal serine/threonine-protein kinase JIL-1

3

14

Small-scale

0.658

High

381747

Q9W396
FI06908p

1

20

Small-scale

0.648

High

121772

M9PGH7
G9a, isoform B

1

20

Small-scale

0.647

High

121961

M9PH39
histone acetyltransferase

1

20

Small-scale

0.647

High

381686

H3
Histone H3

1

16

Small-scale

0.647

High

381697

MSL3
Protein male-specific lethal-3

1

11

Small-scale

0.647

High

381705

SETB1
Histone-lysine N-methyltransferase eggless

1

20

Small-scale

0.647

High

381707

SET1
Histone-lysine N-methyltransferase SETD1

1

20

Small-scale

0.647

High

381742

LSDA
Possible lysine-specific histone demethylase 1

1

8

Small-scale

0.647

High

381689

GROU
Protein groucho

2

10

Small-scale

0.638

High

356706

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

1

20

Small-scale

0.618

High

381692

BRM
ATP-dependent helicase brm

1

20

Small-scale

0.618

High

381720

ASF1
Histone chaperone asf1

1

19

Small-scale

0.618

High

381722

CID
Histone H3-like centromeric protein cid

1

16

Small-scale

0.618

High

381746

Q9W1G7
LD21576p

1

19

Small-scale

0.618

High

381748

Q9W3D1
Chromatin assembly factor 1, p180 subunit

1

20

Small-scale

0.618

High

381724

PYGO
Protein pygopus

3

3

Small-scale

0.594

High

381713

Q8MSC4
CG3509 protein

1

0

Small-scale

0.586

High

54146

A1Z898
Chromatin assembly factor 1, p105 subunit

2

20

Small-scale

0.584

High

145736

MOF
Histone acetyltransferase MOF

1

20

Small-scale

0.579

High

381732

SCM
Polycomb protein Scm

1

20

Small-scale

0.568

High

84933

B7Z0T5
Metastasis-associated protein MTA3

1

20

Small-scale

0.555

High

381723

Q9V9T4
ATP-dependent chromatin assembly factor large subunit

1

20

Small-scale

0.553

High

381725

Q9VC96
BRWD3

1

17

Small-scale

0.553

High

381735

Q9VKD5
Polycomb protein esc

1

12

Small-scale

0.553

High

381734

SMBT
Polycomb protein Sfmbt

2

20

Small-scale

0.550

High

381717

SUZ12
Polycomb protein Su(z)12

1

4

Small-scale

0.501

High

381718

KDM4A
Probable lysine-specific demethylase 4A

1

20

Small-scale

0.501

High

381721

KDM4B
Probable lysine-specific demethylase 4B

1

20

Small-scale

0.501

High

381712

TRR
Histone-lysine N-methyltransferase trr

1

20

High-throughput

0.492

High

381688

FSH
Homeotic protein female sterile

1

20

Small-scale

0.479

High

381694

1433Z
14-3-3 protein zeta

1

5

Small-scale

0.479

High

381698

FKB39
39 kDa FK506-binding nuclear protein

1

7

Small-scale

0.479

High

381706

Q4V5A7
IP14655p

1

20

Small-scale

0.479

High

381726

Q9VCG6
IP14417p1

1

20

Small-scale

0.479

High

381750

Q9W5W9
LD43541p

1

20

Small-scale

0.479

High

381730

Q9VGW7
type I protein arginine methyltransferase

1

16

Small-scale

0.457

High

381731

CARM1
Probable histone-arginine methyltransferase CARMER

1

16

Small-scale

0.457

High

381733

JHD1
JmjC domain-containing histone demethylation protein 1

1

20

Small-scale

0.457

High

381751

EAF3
NuA4 complex subunit EAF3 homolog

1

15

Small-scale

0.457

High

381701

PCL
Polycomb protein Pcl

1

20

Small-scale

0.445

High

381699

BSH
Brain-specific homeobox protein

1

2

High-throughput

0.437

High

381704

NLP
Nucleoplasmin-like protein

1

6

Small-scale

0.437

High

381710

Q7KMQ6
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.437

High

381714

Q8T0D3
Protein DEK

1

4

Small-scale

0.437

High

381716

Q961B8
ADD domain-containing protein 1, isoform B

1

12

Small-scale

0.437

High

381728

Q9VEW6
IP01015p

1

7

High-throughput

0.437

High

381743

Q9VWS0
Inhibitor of growth protein

1

20

Small-scale

0.437

High

381749

SPT6H
Transcription elongation factor SPT6

1

12

Small-scale

0.437

High

381738

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

1

Small-scale

0.407

High

381691

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.348

High

381703

Q27393
Aurora kinase

1

20

High-throughput

0.348

High

381736

AURKB
Aurora kinase B

1

20

High-throughput

0.348

High

53539

A1Z803
FI02892p

1

0

High-throughput

0.249

Low

304905

CRY1
Cryptochrome-1

1

0

High-throughput

0.249

Low

381709

Q7K304
DNAation factor-related protein 2, isoform A

1

0

Small-scale

0.249

Low

381715

Q8T921
AT04454p

1

0

High-throughput

0.249

Low

381739

PYRG
CTP synthase

1

0

High-throughput

0.249

Low

381740

ATRIP
ATR-interacting protein mus304

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025