Protein: GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1)

Gene: GA45A, GADD45A
Organism: Homo sapiens
Interactions: 96
UniProt ID: P24522

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

622919

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

2

3

Small-scale

0.812

High

517056

PCNA
Proliferating cell nuclear antigen

10

4

Small-scale

0.759

High

414743

CDK1
Cyclin-dependent kinase 1

8

2

Small-scale

0.756

High

622927

CDN1A
Cyclin-dependent kinase inhibitor 1

5

2

Small-scale

0.716

High

622945

DCTN2
Dynactin subunit 2

4

1

High-throughput

0.694

High

622938

EF1A1
Elongation factor 1-alpha 1

3

1

Small-scale

0.671

High

622942

TLE1
Transducin-like enhancer protein 1

1

1

High-throughput

0.656

High

622989

M3K4
Mitogen-activated protein kinase kinase kinase 4

2

2

Small-scale

0.636

High

622937

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.622

High

258863

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

1

3

Small-scale

0.618

High

309834

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

3

Small-scale

0.618

High

622986

FBW1A
F-box/WD repeat-containing protein 1A

1

1

Small-scale

0.618

High

622967

CNOT9
CCR4-NOT transcription complex subunit 9

2

3

High-throughput

0.606

High

622977

PARVG
Gamma-parvin

2

2

High-throughput

0.606

High

417943

NPM
Nucleophosmin

2

0

Small-scale

0.603

High

587118

RXRA
Retinoic acid receptor RXR-alpha

2

6

Small-scale

0.600

High

622985

CD11A
Cyclin-dependent kinase 11A

2

5

Small-scale

0.586

High

622965

G45IP
Large ribosomal subunit protein mL64

1

2

Small-scale

0.586

High

160386

AURKA
Aurora kinase A

2

0

Small-scale

0.577

High

386114

P53
Cellular tumor antigen p53

2

0

Small-scale

0.575

High

622987

SHLB1
Endophilin-B1

1

2

High-throughput

0.573

High

622925

ERCC5
DNA excision repair protein ERCC-5

1

0

Small-scale

0.537

High

622929

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.537

High

622941

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.537

High

622952

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

1

High-throughput

0.536

High

622956

SETX
Probable helicase senataxin

1

1

High-throughput

0.536

High

622920

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.518

High

622972

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.518

High

622946

TDG
G/T mismatch-specific thymine DNA glycosylase

1

1

Small-scale

0.515

High

123179

CBX4
E3 SUMO-protein ligase CBX4

1

0

High-throughput

0.513

High

622960

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.513

High

622976

CSR2B
Cysteine-rich protein 2-binding protein

1

0

High-throughput

0.513

High

622978

KBRS2
NF-kappa-B inhibitor-interacting Ras-like protein 2

1

0

High-throughput

0.513

High

622982

PALD
Paladin

1

0

High-throughput

0.513

High

622983

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.513

High

622988

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.513

High

622922

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.508

High

622932

MASP1
Mannan-binding lectin serine protease 1

1

2

High-throughput

0.508

High

622951

MIDN
Midnolin

1

1

High-throughput

0.508

High

622966

MICA1
[F-actin]-monooxygenase MICAL1

1

2

High-throughput

0.508

High

622973

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

1

High-throughput

0.508

High

538470

CCNB1
G2/mitotic-specific cyclin-B1

1

2

Small-scale

0.501

High

622971

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.500

High

622968

KLK6
Kallikrein-6

1

0

High-throughput

0.493

High

622961

TRM2A
tRNA

1

1

High-throughput

0.489

High

622975

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

1

High-throughput

0.489

High

273508

ADAP1
Arf-GAP with dual PH domain-containing protein 1

1

0

High-throughput

0.486

High

381802

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.486

High

402817

TETN
Tetranectin

1

0

High-throughput

0.486

High

422487

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.486

High

443337

VIME
Vimentin

1

0

High-throughput

0.486

High

550611

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.486

High

622926

GBP2
Guanylate-binding protein 2

1

0

High-throughput

0.486

High

622931

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.486

High

622933

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

0

High-throughput

0.486

High

622934

ZN135
Zinc finger protein 135

1

0

High-throughput

0.486

High

622935

LMO4
LIM domain transcription factor LMO4

1

0

High-throughput

0.486

High

622943

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.486

High

622944

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.486

High

622949

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

High-throughput

0.486

High

622957

RAI1
Retinoic acid-induced protein 1

1

0

High-throughput

0.486

High

622958

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.486

High

622969

FUBP2
Far upstream element-binding protein 2

1

0

High-throughput

0.486

High

622974

FA83D
Protein FAM83D

1

0

High-throughput

0.486

High

622979

NRBP
Nuclear receptor-binding protein

1

0

High-throughput

0.486

High

622981

ZHX1
Zinc fingers and homeoboxes protein 1

1

0

High-throughput

0.486

High

369001

ESR1
Estrogen receptor

1

7

Small-scale

0.479

High

487902

RARA
Retinoic acid receptor alpha

1

9

Small-scale

0.479

High

622923

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

Small-scale

0.479

High

622928

STAT3
Signal transducer and activator of transcription 3

1

1

Small-scale

0.479

High

622959

CDAN1
Codanin-1

1

1

Small-scale

0.479

High

597362

PTN
Pleiotrophin

1

1

High-throughput

0.464

High

572855

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.460

High

622930

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.460

High

453152

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

622921

DNMT1
DNA

1

0

Small-scale

0.458

High

622924

MK01
Mitogen-activated protein kinase 1

1

0

Small-scale

0.458

High

622936

RS7
Small ribosomal subunit protein eS7

1

0

Small-scale

0.458

High

622984

ING4
Inhibitor of growth protein 4

1

0

Small-scale

0.458

High

622948

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

1

High-throughput

0.439

High

364831

FRIL
Ferritin light chain

1

0

High-throughput

0.438

High

622954

CREL2
Protein disulfide isomerase CRELD2

1

1

High-throughput

0.417

High

622939

NUCB2
Nucleobindin-2

1

0

High-throughput

0.299

High

622963

LNX2
Ligand of Numb protein X 2

1

0

High-throughput

0.292

High

622964

CBY2
Protein chibby homolog 2

1

0

High-throughput

0.292

High

622953

PR14L
Protein PRR14L

1

0

High-throughput

0.279

Low

622947

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.268

Low

257024

DJC13
DnaJ homolog subfamily C member 13

1

0

High-throughput

0.265

Low

622940

EM55
55 kDa erythrocyte membrane protein

1

0

High-throughput

0.265

Low

622950

F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

1

0

High-throughput

0.265

Low

622955

FBN3
Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide]

1

0

High-throughput

0.265

Low

622962

SYNE4
Nesprin-4

1

0

High-throughput

0.265

Low

622970

IGS21
Immunoglobulin superfamily member 21

1

0

High-throughput

0.265

Low

622980

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.265

Low

353910

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024