HitPredict

Interactor 1: HDAC1 (Q94517)
Histone deacetylase HDAC1 (HD) (EC 3.5.1.98)
Gene: HDAC1

Interactor 2: Q9VYI2 (Q9VYI2)
BRMS1 transcriptional repressor (LD14895p)
Gene: Brms1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	38944040
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Hist_deacetyl~Sds3
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0070822 - Sin3-type complex
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 521 Dm			1 259
+	Hs
		1208625 HDAC2_HUMAN (2-488): 0: 659: 76.59		BRM1L_HUMAN (11-225): 5.57e-80: 245: 40.18
+	Hs
		1368135 HDAC2_HUMAN (2-488): 0: 659: 76.59		BRMS1_HUMAN (1-224): 3.45e-78: 238: 37.50
+	Hs
		1109793 HDAC1_HUMAN (3-443): 0: 637: 81.18		BRM1L_HUMAN (11-225): 5.57e-80: 245: 40.18
+	Hs
		1110100 HDAC1_HUMAN (3-443): 0: 637: 81.18		BRMS1_HUMAN (1-224): 3.45e-78: 238: 37.50
+	Mm
		148734 HDAC1_MOUSE (3-443): 0: 640: 81.18		BRMS1_MOUSE (1-224): 5.19e-77: 235: 36.64
+	Hs
		96986 HDAC1_HUMAN (3-443): 0: 637: 81.18		E9PJF5_HUMAN (1-224): 1.91e-77: 236: 37.50
+	Hs
		1368126 HDAC2_HUMAN (2-488): 0: 659: 76.59		SDS3_HUMAN (40-223): 4.36e-50: 168: 26.18
+	Hs
		188370 HDAC3_HUMAN (6-427): 0: 572: 56.37		BRMS1_HUMAN (1-224): 3.45e-78: 238: 37.50
+	Hs
		1110085 HDAC1_HUMAN (3-443): 0: 637: 81.18		SDS3_HUMAN (40-223): 4.36e-50: 168: 26.18
+	Hs
		941062 HDAC4_HUMAN (5-405): 2.09e-133: 415: 22.86		BRMS1_HUMAN (1-224): 3.45e-78: 238: 37.50
+	Hs
		1439492 HDAC6_HUMAN (9-323): 1.24e-99: 327: 23.55		BRMS1_HUMAN (1-224): 3.45e-78: 238: 37.50