Protein: HDAC1
Histone deacetylase HDAC1 (HD) (EC 3.5.1.98)

Gene: HDAC1
Organism: Drosophila melanogaster
Interactions: 81
UniProt ID: Q94517

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity
GO:0004407 - histone deacetylase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1216737

Q5U0Y0
Paired amphipathic helix protein Sin3a

6

20

Small-scale

0.920

High

1374480

Q9VHB7
LD22928p

4

9

Small-scale

0.904

High

356804

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

4

20

Small-scale

0.895

High

1374486

KDM5
Lysine-specific demethylase 5

3

18

Small-scale

0.827

High

1202433

RCOR
REST corepressor

3

20

Small-scale

0.817

High

84936

B7Z0T5
Metastasis-associated protein MTA3

2

20

Small-scale

0.754

High

1374503

Q9W410
PHD finger protein 12

2

20

Small-scale

0.754

High

52476

A1Z6Z7
Uncharacterized protein, isoform A

2

20

High-throughput

0.737

High

1173872

ESC
Polycomb protein esc

5

20

Small-scale

0.727

High

1374489

Q9VNF6
Metastasis-associated protein MTA3

2

20

High-throughput

0.712

High

1175596

CAF1
Chromatin assembly factor 1 p55 subunit

4

20

Small-scale

0.701

High

837320

EZ
Histone-lysine N-methyltransferase E(z)

3

20

Small-scale

0.685

High

683685

PC
Polycomb group protein Pc

3

14

Small-scale

0.656

High

1374497

LSDA
Possible lysine-specific histone demethylase 1

3

10

Small-scale

0.640

High

594699

GROU
Protein groucho

3

17

Small-scale

0.625

High

72172

A8WHL4
Bonus, isoform B

1

20

Small-scale

0.618

High

1374477

Q9VDK5
Bonus, isoform A

1

20

Small-scale

0.618

High

1374488

Q9VNC2
Histone deacetylase

1

16

Small-scale

0.618

High

853556

SUV39
Histone-lysine N-methyltransferase Su(var)3-9

2

20

Small-scale

0.611

High

1069298

Q0E8J0
MOG interacting and ectopic P-granules protein 1

2

9

Small-scale

0.611

High

1174284

PCL
Polycomb protein Pcl

1

18

Small-scale

0.586

High

91284

C6SV09
IP16414p

2

1

Small-scale

0.584

High

1285562

Q86BH2
Grunge, isoform C

2

20

Small-scale

0.584

High

1374499

Q9VYI2
BRMS1 transcriptional repressor

1

11

High-throughput

0.575

High

1374494

Q9VTX2
RE32936p

1

4

Small-scale

0.561

High

1172398

HR78
Nuclear hormone receptor HR78

1

20

High-throughput

0.541

High

55385

LIN54
Protein lin-54 homolog

1

5

Small-scale

0.536

High

613693

JRA
Transcription factor Jra

1

16

Small-scale

0.536

High

1172563

STAT
Signal transducer and transcription activator

1

12

Small-scale

0.536

High

1174512

HMG2
High mobility group protein DSP1

1

18

Small-scale

0.536

High

1303591

FRU
Sex determination protein fruitless

1

20

Small-scale

0.536

High

1374496

Q9VUB5
UpSET, isoform A

1

7

Small-scale

0.536

High

1374495

AGT2L
Alanine--glyoxylate aminotransferase 2-like

2

1

High-throughput

0.521

High

713690

ABDA
Homeobox protein abdominal-A

1

10

High-throughput

0.481

High

1014344

UBX
Homeotic protein ultrabithorax

1

6

High-throughput

0.481

High

92060

D1YSG4
CORL

1

5

Small-scale

0.479

High

118524

M9NEW2
Histone acetyltransferase

1

8

Small-scale

0.479

High

120327

M9PD17
Gigas, isoform B

1

1

High-throughput

0.479

High

120855

M9PEA2
CDK2-associated protein 1, isoform B

1

6

Small-scale

0.479

High

121777

M9PGH7
G9a, isoform B

1

20

Small-scale

0.479

High

121994

M9PH39
histone acetyltransferase

1

20

Small-scale

0.479

High

624355

CI
Transcriptional activator cubitus interruptus

1

10

Small-scale

0.479

High

638761

FOSLA
Transcription factor kayak, isoforms A/B/F

1

20

Small-scale

0.479

High

701295

SUH
Suppressor of hairless protein

1

4

High-throughput

0.479

High

1064541

GAGA
Transcription activator GAGA

1

20

Small-scale

0.479

High

1173801

DSOR1
Dual specificity mitogen-activated protein kinase kinase dSOR1

1

9

High-throughput

0.479

High

1173920

ISWI
Chromatin-remodeling complex ATPase chain Iswi

1

20

Small-scale

0.479

High

1174314

RBF
Retinoblastoma family protein

1

12

Small-scale

0.479

High

1267776

Q7KMQ6
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.479

High

1374468

Q960V1
LD33361p

1

4

Small-scale

0.479

High

1374469

Q9NHX6
GRUNGE

1

20

Small-scale

0.479

High

1374470

SUZ12
Polycomb protein Su(z)12

1

3

Small-scale

0.479

High

1374471

Q9U8L5
Dorsocross1, isoform A

1

7

Small-scale

0.479

High

1374472

Q9V3B8
LD18634p

1

5

Small-scale

0.479

High

1374473

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

5

High-throughput

0.479

High

1374474

Q9VB52
LD05287p

1

14

Small-scale

0.479

High

1374475

Q9VCC9
LD23779p

1

20

High-throughput

0.479

High

1374478

Q9VF04
RE32990p

1

12

Small-scale

0.479

High

1374479

EXOSX
Exosome complex component 10 homolog

1

3

Small-scale

0.479

High

1374481

SMBT
Polycomb protein Sfmbt

1

12

Small-scale

0.479

High

1374482

Q9VKD5
Polycomb protein esc

1

20

Small-scale

0.479

High

1374483

PIWI
Protein piwi

1

6

Small-scale

0.479

High

1374492

Q9VQ58
BRCA2-interacting transcriptional repressor EMSY

1

2

High-throughput

0.479

High

1374493

Q9VR61
non-specific serine/threonine protein kinase

1

9

High-throughput

0.479

High

1374502

Q9W1G7
LD21576p

1

2

High-throughput

0.479

High

1374504

Q9W5E2
EG:115C2.8 protein

1

2

Small-scale

0.479

High

1374505

EAF3
NuA4 complex subunit EAF3 homolog

1

11

Small-scale

0.479

High

875110

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.464

High

55081

A1Z921
Frazzled, isoform B

1

0

Small-scale

0.458

High

1343461

ASTRX
Gametocyte-specific factor 1 homolog

1

0

Small-scale

0.458

High

1374484

Q9VL20
Ovaries absent, isoform A

1

0

Small-scale

0.458

High

1374491

Q9VPY3
Charon

1

0

Small-scale

0.458

High

1014792

H4
Histone H4

1

13

Small-scale

0.457

High

1374500

Q9VZ22
L(3)mbt interacting protein 1, isoform A

1

1

High-throughput

0.445

High

1374501

Q9VZ27
CDK2-associated protein 1, isoform A

1

6

Small-scale

0.445

High

1172947

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

9

Small-scale

0.437

High

1374476

EI3D1
Eukaryotic translation initiation factor 3 subunit D-1

1

0

Small-scale

0.426

High

1374490

HPF1
Histone PARylation factor 1-like

1

0

High-throughput

0.426

High

1374485

Q9VM11
HL01515p

1

0

High-throughput

0.249

Low

1374487

ORCO
Odorant receptor coreceptor

1

0

Small-scale

0.249

Low

1374498

Q9VWJ6
FI03615p

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025